YPR159C-A_p

Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR159C-A / YPR159C-A

Click on Significant Values for Screen Details ID:SGTC_236|Compound:1509-0011|FD-Score:3.87|P-value:4.34E-6 ID:SGTC_264|Compound:promethazine|FD-Score:-2.87|P-value:4.26E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-2.88|P-value:4.08E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:2.77|P-value:7.34E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.91|P-value:3.39E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.13|P-value:1.40E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:2.77|P-value:7.28E-4 ID:SGTC_433|Compound:pimozide|FD-Score:3.69|P-value:1.13E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:3.10|P-value:1.89E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:7.09|P-value:1.52E-16 ID:SGTC_785|Compound:1270-0111|FD-Score:-7.03|P-value:1.92E-16 ID:SGTC_797|Compound:k781-0471|FD-Score:-2.93|P-value:3.23E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:-2.98|P-value:2.64E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.13|P-value:1.60E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.23|P-value:8.84E-5 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.50|P-value:2.40E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:-3.38|P-value:4.21E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.72|P-value:7.79E-6 ID:SGTC_1452|Compound:4194-0072|FD-Score:2.84|P-value:5.57E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.72|P-value:7.93E-6 ID:SGTC_1851|Compound:st056236|FD-Score:3.33|P-value:6.59E-5 ID:SGTC_1910|Compound:st062352|FD-Score:-4.03|P-value:1.44E-6 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.05|P-value:2.32E-4 ID:SGTC_2014|Compound:4013930|FD-Score:2.87|P-value:4.85E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.50|P-value:2.95E-5 ID:SGTC_2113|Compound:5491891|FD-Score:2.93|P-value:3.83E-4 ID:SGTC_2121|Compound:5257820|FD-Score:2.76|P-value:7.59E-4 ID:SGTC_2122|Compound:5258151|FD-Score:-4.51|P-value:8.13E-8 ID:SGTC_2123|Compound:5259487|FD-Score:3.03|P-value:2.51E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.13|P-value:1.40E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:2.80|P-value:6.58E-4 ID:SGTC_2344|Compound:7990960|FD-Score:4.08|P-value:1.38E-6 ID:SGTC_2351|Compound:9026858|FD-Score:-5.27|P-value:5.02E-10 ID:SGTC_2372|Compound:9071633|FD-Score:2.93|P-value:3.90E-4 ID:SGTC_2412|Compound:st077135|FD-Score:2.96|P-value:3.45E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.69|P-value:8.77E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.92|P-value:4.49E-12 ID:SGTC_2802|Compound:7925815|FD-Score:-3.39|P-value:4.18E-5 ID:SGTC_2918|Compound:7977171|FD-Score:3.39|P-value:4.94E-5 ID:SGTC_2922|Compound:7999257|FD-Score:-2.76|P-value:6.54E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-2.71|P-value:8.21E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-2.72|P-value:7.79E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-2.84|P-value:4.75E-4 ID:SGTC_2987|Compound:9018338|FD-Score:-3.15|P-value:1.26E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.87|P-value:4.34E-6 ID:SGTC_264|Compound:promethazine|FD-Score:-2.87|P-value:4.26E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-2.88|P-value:4.08E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:2.77|P-value:7.34E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.91|P-value:3.39E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.13|P-value:1.40E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:2.77|P-value:7.28E-4 ID:SGTC_433|Compound:pimozide|FD-Score:3.69|P-value:1.13E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:3.10|P-value:1.89E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:7.09|P-value:1.52E-16 ID:SGTC_785|Compound:1270-0111|FD-Score:-7.03|P-value:1.92E-16 ID:SGTC_797|Compound:k781-0471|FD-Score:-2.93|P-value:3.23E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:-2.98|P-value:2.64E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.13|P-value:1.60E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.23|P-value:8.84E-5 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.50|P-value:2.40E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:-3.38|P-value:4.21E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.72|P-value:7.79E-6 ID:SGTC_1452|Compound:4194-0072|FD-Score:2.84|P-value:5.57E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.72|P-value:7.93E-6 ID:SGTC_1851|Compound:st056236|FD-Score:3.33|P-value:6.59E-5 ID:SGTC_1910|Compound:st062352|FD-Score:-4.03|P-value:1.44E-6 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.05|P-value:2.32E-4 ID:SGTC_2014|Compound:4013930|FD-Score:2.87|P-value:4.85E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.50|P-value:2.95E-5 ID:SGTC_2113|Compound:5491891|FD-Score:2.93|P-value:3.83E-4 ID:SGTC_2121|Compound:5257820|FD-Score:2.76|P-value:7.59E-4 ID:SGTC_2122|Compound:5258151|FD-Score:-4.51|P-value:8.13E-8 ID:SGTC_2123|Compound:5259487|FD-Score:3.03|P-value:2.51E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.13|P-value:1.40E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:2.80|P-value:6.58E-4 ID:SGTC_2344|Compound:7990960|FD-Score:4.08|P-value:1.38E-6 ID:SGTC_2351|Compound:9026858|FD-Score:-5.27|P-value:5.02E-10 ID:SGTC_2372|Compound:9071633|FD-Score:2.93|P-value:3.90E-4 ID:SGTC_2412|Compound:st077135|FD-Score:2.96|P-value:3.45E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.69|P-value:8.77E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.92|P-value:4.49E-12 ID:SGTC_2802|Compound:7925815|FD-Score:-3.39|P-value:4.18E-5 ID:SGTC_2918|Compound:7977171|FD-Score:3.39|P-value:4.94E-5 ID:SGTC_2922|Compound:7999257|FD-Score:-2.76|P-value:6.54E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-2.71|P-value:8.21E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-2.72|P-value:7.79E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-2.84|P-value:4.75E-4 ID:SGTC_2987|Compound:9018338|FD-Score:-3.15|P-value:1.26E-4

Top fitness defect scores for YPR159C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_774 k060-0086 7.09 136.0 µM 1.52E-16 5 6.57E-13
2 SGTC_2752 diclazuril 5.92 33.1 µM 4.49E-12 58 1.57E-9
3 SGTC_2344 7990960 4.08 77.0 µM 1.38E-6 24 2.28E-5
4 SGTC_376 3970-0862 3.91 59.1 µM 3.39E-6 20 4.52E-5
5 SGTC_236 1509-0011 3.87 5.3 µM 4.34E-6 389 5.46E-5
6 SGTC_433 pimozide 3.69 108.0 µM 1.13E-5 22 1.13E-4
7 SGTC_2107 5363541 3.50 170.2 µM 2.95E-5 18 2.36E-4
8 SGTC_2918 7977171 3.39 22.1 µM 4.94E-5 45 3.50E-4
9 SGTC_1851 st056236 3.33 18.9 µM 6.59E-5 34 4.36E-4
10 SGTC_912 3474-0017 3.13 2.2 µM 1.60E-4 57 8.61E-4
11 SGTC_438 sphingosine 3.10 6.7 µM 1.89E-4 55 9.78E-4
12 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.05 70.1 µM 2.32E-4 83 0.00114
13 SGTC_2123 5259487 3.03 200.0 µM 2.51E-4 52 0.00122
14 SGTC_2412 st077135 2.96 33.4 µM 3.45E-4 75 0.00156
15 SGTC_2113 5491891 2.93 107.0 µM 3.83E-4 TSC3-RPN4 81 0.00169
16 SGTC_2372 9071633 2.93 200.0 µM 3.90E-4 49 0.00171
17 SGTC_2014 4013930 2.87 200.0 µM 4.85E-4 100 0.00202
18 SGTC_1452 4194-0072 2.84 190.0 µM 5.57E-4 67 0.00225
19 SGTC_2251 lansoprazole 2.80 556.0 µM 6.58E-4 59 0.00256
20 SGTC_400 oxethazaine 2.77 37.5 µM 7.28E-4 calcium & mitochondrial duress 72 0.00276

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.199 2.00E-31 YEL060C PRB1 hom Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.199 2.33E-31 YDR517W GRH1 hom Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress
0.167 2.43E-22 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.146 2.32E-17 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.145 2.62E-17 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.143 7.41E-17 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.140 4.81E-16 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.138 9.18E-16 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.138 1.01E-15 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.138 1.14E-15 YDR497C ITR1 hom Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress
0.138 1.26E-15 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.132 1.33E-14 YKL018C-A_p YKL018C-A_p hom Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.131 3.18E-14 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.130 4.65E-14 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.128 8.67E-14 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20