YPR160W / GPH1

Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR160W / GPH1

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:2.92|P-value:6.26E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.09|P-value:3.33E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:2.82|P-value:9.06E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:4.24|P-value:1.56E-6 ID:SGTC_428|Compound:3448-4153|FD-Score:3.52|P-value:5.37E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:3.02|P-value:4.37E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.17|P-value:2.27E-6 ID:SGTC_646|Compound:4092-0839|FD-Score:3.27|P-value:1.59E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:2.85|P-value:8.16E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:2.81|P-value:9.74E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:2.91|P-value:6.53E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.60|P-value:5.14E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.21|P-value:2.73E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:-6.09|P-value:2.11E-11 ID:SGTC_968|Compound:1309-0633|FD-Score:4.83|P-value:5.53E-8 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:2.99|P-value:4.91E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.27|P-value:1.59E-4 ID:SGTC_2035|Compound:5154463|FD-Score:2.94|P-value:5.86E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-2.90|P-value:8.90E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.36|P-value:1.09E-4 ID:SGTC_2350|Compound:9023895|FD-Score:2.88|P-value:7.48E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-2.89|P-value:9.48E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:5.86|P-value:6.28E-11 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.13|P-value:2.74E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:4.52|P-value:3.48E-7 ID:SGTC_2857|Compound:9024691|FD-Score:-2.87|P-value:9.93E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-2.89|P-value:9.23E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-3.37|P-value:1.41E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.19|P-value:2.19E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.41|P-value:8.66E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:2.92|P-value:6.26E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.09|P-value:3.33E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:2.82|P-value:9.06E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:4.24|P-value:1.56E-6 ID:SGTC_428|Compound:3448-4153|FD-Score:3.52|P-value:5.37E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:3.02|P-value:4.37E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.17|P-value:2.27E-6 ID:SGTC_646|Compound:4092-0839|FD-Score:3.27|P-value:1.59E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:2.85|P-value:8.16E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:2.81|P-value:9.74E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:2.91|P-value:6.53E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.60|P-value:5.14E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.21|P-value:2.73E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:-6.09|P-value:2.11E-11 ID:SGTC_968|Compound:1309-0633|FD-Score:4.83|P-value:5.53E-8 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:2.99|P-value:4.91E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.27|P-value:1.59E-4 ID:SGTC_2035|Compound:5154463|FD-Score:2.94|P-value:5.86E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-2.90|P-value:8.90E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.36|P-value:1.09E-4 ID:SGTC_2350|Compound:9023895|FD-Score:2.88|P-value:7.48E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-2.89|P-value:9.48E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:5.86|P-value:6.28E-11 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.13|P-value:2.74E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:4.52|P-value:3.48E-7 ID:SGTC_2857|Compound:9024691|FD-Score:-2.87|P-value:9.93E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-2.89|P-value:9.23E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-3.37|P-value:1.41E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.19|P-value:2.19E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.41|P-value:8.66E-5

Top fitness defect scores for YPR160W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 5.86 100.0 µM 6.28E-11 10 2.27E-9
2 SGTC_968 1309-0633 4.83 340.0 µM 5.53E-8 5 6.74E-7
3 SGTC_2640 pentamidine 4.52 10.4 µM 3.48E-7 mitochondrial processes 19 3.16E-6
4 SGTC_363 0455-0021 4.24 3.1 µM 1.56E-6 azole & statin 54 1.12E-5
5 SGTC_430 0958-0115 4.17 16.4 µM 2.27E-6 22 1.53E-5
6 SGTC_428 3448-4153 3.52 16.5 µM 5.37E-5 TSC3-RPN4 49 2.19E-4
7 SGTC_3352 9151559 3.41 45.6 µM 8.66E-5 25 3.27E-4
8 SGTC_2329 6138490 3.36 200.0 µM 1.09E-4 59 3.96E-4
9 SGTC_1919 st067113 3.27 52.3 µM 1.59E-4 TSC3-RPN4 55 5.45E-4
10 SGTC_646 4092-0839 3.27 27.3 µM 1.59E-4 plasma membrane duress 48 5.46E-4
11 SGTC_3204 9114183 3.19 49.5 µM 2.19E-4 67 7.16E-4
12 SGTC_2639 lactacystin 3.13 53.0 µM 2.74E-4 63 8.64E-4
13 SGTC_241 5hr heat shock (37°C) + cantharidin 3.09 155.4 µM 3.33E-4 cell wall signaling 117 0.00102
14 SGTC_429 1112-0049 3.02 25.5 µM 4.37E-4 DNA damage response 78 0.00128
15 SGTC_1135 dihydrocapsaicin 2.99 536.7 nM 4.91E-4 82 0.00141
16 SGTC_2035 5154463 2.94 94.6 µM 5.86E-4 67 0.00164
17 SGTC_38 0929-0051 2.92 58.3 µM 6.26E-4 79 0.00173
18 SGTC_945 3381-0768 2.91 11.3 µM 6.53E-4 endomembrane recycling 84 0.00180
19 SGTC_2350 9023895 2.88 38.9 µM 7.48E-4 ergosterol biosynthesis 83 0.00201
20 SGTC_716 1683-5115 2.85 658.0 µM 8.16E-4 81 0.00217

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.196 2.48E-30 YLL063C AYT1 hom Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis
0.177 5.17E-25 YPL258C THI21 hom Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p
0.142 1.33E-16 YIL120W QDR1 hom Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication
0.141 2.68E-16 YJL203W PRP21 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.137 1.31E-15 YKL116C PRR1 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
0.123 8.09E-13 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.123 8.39E-13 YPL263C KEL3 hom Cytoplasmic protein of unknown function
0.121 2.21E-12 YNR003C RPC34 het RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
0.120 3.74E-12 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.118 6.59E-12 YIL046W-A_p YIL046W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.117 1.15E-11 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.111 1.24E-10 YOR177C MPC54 hom Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate
0.105 9.18E-10 YPL224C MMT2 hom Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p
0.102 2.72E-9 YNL045W LAP2 hom Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.102 3.39E-9 YMR175W-A_p YMR175W-A_p hom Putative protein of unknown function