HIPHOP chemogenomics database

YPR166C / MRP2

Mitochondrial ribosomal protein of the small subunit

Zygosity: Homozygous strain

fixedexpanded
Profile for YPR166C / MRP2

Click on Significant Values for Screen Details

Top fitness defect scores for YPR166C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	20.70	5.3 µM	4.37E-77		49	6.15E-96
2	SGTC_275	trichlorophene	15.90	5.7 µM	2.95E-46	mitochondrial stress	7	2.23E-57
3	SGTC_70	0141-0289	9.75	43.3 µM	1.47E-18	mitochondrial stress	19	9.22E-23
4	SGTC_908	3448-7491	9.10	47.7 µM	2.16E-16	mitochondrial stress	12	4.70E-20
5	SGTC_386	1509-0011	8.27	3.1 µM	7.38E-14		59	6.80E-17
6	SGTC_173	1273-0061	8.18	2.7 µM	1.34E-13	mitochondrial stress	62	1.44E-16
7	SGTC_1882	5615643	7.44	20.0 µM	1.50E-11	TRP & mitochondrial translation	11	5.13E-14
8	SGTC_1883	5-benzylidenerhodanine	7.39	20.0 µM	1.98E-11	TRP & mitochondrial translation	13	7.25E-14
9	SGTC_2598	perillyl alcohol	5.76	100.0 µM	1.35E-7		7	4.33E-9
10	SGTC_2183	6420625	5.74	130.5 µM	1.45E-7	mitochondrial processes	16	4.72E-9
11	SGTC_2232	chlorophetanol	5.38	41.5 µM	7.70E-7	TRP & mitochondrial translation	59	3.76E-8
12	SGTC_310	1273-0058	5.09	1.1 µM	2.75E-6	mitochondrial stress	180	1.83E-7
13	SGTC_1742	st038235	4.96	28.9 µM	4.62E-6	mitochondrial stress	77	3.49E-7
14	SGTC_1906	st060206	4.93	94.7 µM	5.30E-6		9	4.14E-7
15	SGTC_748	0136-0228	4.82	77.9 µM	8.34E-6	redox potentiating	49	7.25E-7
16	SGTC_3239	9133757	4.78	49.5 µM	9.87E-6		1	8.94E-7
17	SGTC_1188	1403-0014	4.75	4.6 µM	1.07E-5	mitochondrial stress	32	9.93E-7
18	SGTC_966	1300-0360	4.57	30.2 µM	2.21E-5	heme requiring	14	2.43E-6
19	SGTC_1635	st007035	4.56	42.4 µM	2.32E-5		181	2.58E-6
20	SGTC_119	0121-0043	4.55	24.8 µM	2.42E-5	mitochondrial stress	74	2.72E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.615	0	YNL252C	MRPL17	hom	Mitochondrial ribosomal protein of the large subunit
0.612	0	YDR518W	EUG1	hom	Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.600	0	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.579	4.52E-299	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.570	5.22E-288	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.569	1.87E-287	YGR220C	MRPL9	hom	Mitochondrial ribosomal protein of the large subunit
0.566	6.34E-284	YCR024C	SLM5	hom	Mitochondrial asparaginyl-tRNA synthetase
0.555	3.20E-270	YDR237W	MRPL7	hom	Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.544	3.72E-258	YDR533C	HSP31	hom	Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress
0.528	1.59E-240	YOR158W	PET123	hom	Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
0.521	1.62E-232	YKL068W-A_p	YKL068W-A_p	hom	Putative protein of unknown function; identified by homology to Ashbya gossypii
0.519	1.93E-231	YNL184C_p	YNL184C_p	hom	Protein of unknown function; expressed at both mRNA and protein levels
0.519	5.19E-231	YNL213C	RRG9	hom	Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.518	8.44E-230	YGL064C	MRH4	hom	Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.512	1.45E-223	YDR079W	PET100	hom	Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme