HIPHOP chemogenomics database
YPR193C / HPA2 
Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YPR193C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.107 | 5.80E-10 | YLR331C_d | JIP3_d | hom | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2 |
| 0.103 | 2.11E-9 | YCR086W | CSM1 | hom | Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation |
| 0.097 | 1.79E-8 | YGR282C | BGL2 | hom | Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance |
| 0.096 | 2.53E-8 | YLR444C_d | YLR444C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.095 | 3.37E-8 | YPL034W_p | YPL034W_p | hom | Putative protein of unknown function; YPL034W is not essential gene |
| 0.094 | 5.23E-8 | YKL162C-A_d | YKL162C-A_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.093 | 7.51E-8 | YLR150W | STM1 | hom | Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery |
| 0.092 | 1.05E-7 | YIL076W | SEC28 | hom | Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress |
| 0.092 | 1.07E-7 | YLR008C | PAM18 | het | Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p |
| 0.091 | 1.18E-7 | YOR208W | PTP2 | hom | Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus |
| 0.087 | 4.25E-7 | YDR158W | HOM2 | hom | Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis |
| 0.087 | 4.67E-7 | YKL033W-A_p | YKL033W-A_p | hom | Putative protein of unknown function; similar to uncharacterized proteins from other fungi |
| 0.085 | 7.42E-7 | YDR149C_d | YDR149C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth |
| 0.084 | 1.17E-6 | YPL163C | SVS1 | hom | Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication |
| 0.080 | 3.30E-6 | YPR185W | ATG13 | hom | Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling |