YPR196W_p

Putative maltose-responsive transcription factor

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR196W / YPR196W

Click on Significant Values for Screen Details ID:SGTC_78|Compound:0336-0123|FD-Score:-3.15|P-value:6.29E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:3.99|P-value:1.91E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:6.08|P-value:1.82E-10 ID:SGTC_348|Compound:k064-0012|FD-Score:7.89|P-value:2.24E-16 ID:SGTC_353|Compound:1988-1175|FD-Score:4.35|P-value:3.64E-6 ID:SGTC_356|Compound:1634-0012|FD-Score:3.37|P-value:2.53E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-3.58|P-value:1.20E-4 ID:SGTC_459|Compound:nigericin|FD-Score:-3.55|P-value:1.39E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.39|P-value:2.36E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:-3.70|P-value:7.34E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.70|P-value:7.44E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:4.64|P-value:8.36E-7 ID:SGTC_841|Compound:0251-0215|FD-Score:5.57|P-value:4.58E-9 ID:SGTC_956|Compound:1185-0240|FD-Score:4.13|P-value:1.03E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:3.76|P-value:5.26E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.09|P-value:1.23E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.15|P-value:5.79E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.28|P-value:3.58E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.80|P-value:4.42E-5 ID:SGTC_1674|Compound:st016616|FD-Score:3.55|P-value:1.23E-4 ID:SGTC_1794|Compound:st048918|FD-Score:3.08|P-value:7.40E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-3.41|P-value:2.42E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.99|P-value:1.96E-5 ID:SGTC_2008|Compound:4012253|FD-Score:5.28|P-value:2.69E-8 ID:SGTC_2010|Compound:4012422|FD-Score:3.57|P-value:1.14E-4 ID:SGTC_2073|Compound:5212005|FD-Score:-3.25|P-value:4.34E-4 ID:SGTC_2075|Compound:5212009|FD-Score:3.32|P-value:3.11E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.28|P-value:3.61E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.30|P-value:3.24E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.11|P-value:6.62E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.41|P-value:2.16E-4 ID:SGTC_2262|Compound:9014885|FD-Score:3.65|P-value:8.22E-5 ID:SGTC_2421|Compound:5690543|FD-Score:6.25|P-value:5.95E-11 ID:SGTC_2433|Compound:5607874|FD-Score:4.69|P-value:6.61E-7 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-3.32|P-value:3.39E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.03|P-value:1.59E-5 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.21|P-value:4.53E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:5.65|P-value:2.93E-9 ID:SGTC_2983|Compound:9022671|FD-Score:3.64|P-value:8.53E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.69|P-value:7.12E-5 ID:SGTC_2996|Compound:9066192|FD-Score:5.09|P-value:7.67E-8 ID:SGTC_2999|Compound:9069765|FD-Score:-3.98|P-value:2.28E-5 ID:SGTC_3029|Compound:9088683|FD-Score:3.56|P-value:1.20E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.25|P-value:3.93E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.14|P-value:5.97E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.58|P-value:1.19E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.14|P-value:5.92E-4 ID:SGTC_3328|Compound:9140624|FD-Score:-4.85|P-value:3.18E-7 ID:SGTC_3332|Compound:9141069|FD-Score:3.02|P-value:9.02E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.15|P-value:6.29E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:3.99|P-value:1.91E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:6.08|P-value:1.82E-10 ID:SGTC_348|Compound:k064-0012|FD-Score:7.89|P-value:2.24E-16 ID:SGTC_353|Compound:1988-1175|FD-Score:4.35|P-value:3.64E-6 ID:SGTC_356|Compound:1634-0012|FD-Score:3.37|P-value:2.53E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-3.58|P-value:1.20E-4 ID:SGTC_459|Compound:nigericin|FD-Score:-3.55|P-value:1.39E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.39|P-value:2.36E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:-3.70|P-value:7.34E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.70|P-value:7.44E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:4.64|P-value:8.36E-7 ID:SGTC_841|Compound:0251-0215|FD-Score:5.57|P-value:4.58E-9 ID:SGTC_956|Compound:1185-0240|FD-Score:4.13|P-value:1.03E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:3.76|P-value:5.26E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.09|P-value:1.23E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.15|P-value:5.79E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.28|P-value:3.58E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.80|P-value:4.42E-5 ID:SGTC_1674|Compound:st016616|FD-Score:3.55|P-value:1.23E-4 ID:SGTC_1794|Compound:st048918|FD-Score:3.08|P-value:7.40E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-3.41|P-value:2.42E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.99|P-value:1.96E-5 ID:SGTC_2008|Compound:4012253|FD-Score:5.28|P-value:2.69E-8 ID:SGTC_2010|Compound:4012422|FD-Score:3.57|P-value:1.14E-4 ID:SGTC_2073|Compound:5212005|FD-Score:-3.25|P-value:4.34E-4 ID:SGTC_2075|Compound:5212009|FD-Score:3.32|P-value:3.11E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.28|P-value:3.61E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.30|P-value:3.24E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.11|P-value:6.62E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.41|P-value:2.16E-4 ID:SGTC_2262|Compound:9014885|FD-Score:3.65|P-value:8.22E-5 ID:SGTC_2421|Compound:5690543|FD-Score:6.25|P-value:5.95E-11 ID:SGTC_2433|Compound:5607874|FD-Score:4.69|P-value:6.61E-7 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-3.32|P-value:3.39E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.03|P-value:1.59E-5 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.21|P-value:4.53E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:5.65|P-value:2.93E-9 ID:SGTC_2983|Compound:9022671|FD-Score:3.64|P-value:8.53E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.69|P-value:7.12E-5 ID:SGTC_2996|Compound:9066192|FD-Score:5.09|P-value:7.67E-8 ID:SGTC_2999|Compound:9069765|FD-Score:-3.98|P-value:2.28E-5 ID:SGTC_3029|Compound:9088683|FD-Score:3.56|P-value:1.20E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.25|P-value:3.93E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.14|P-value:5.97E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.58|P-value:1.19E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.14|P-value:5.92E-4 ID:SGTC_3328|Compound:9140624|FD-Score:-4.85|P-value:3.18E-7 ID:SGTC_3332|Compound:9141069|FD-Score:3.02|P-value:9.02E-4

Top fitness defect scores for YPR196W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_348 k064-0012 7.89 10.7 µM 2.24E-16 60S ribosome export 2 1.53E-15
2 SGTC_2421 5690543 6.25 90.7 µM 5.95E-11 2 2.05E-10
3 SGTC_342 k048-0088 6.08 23.3 µM 1.82E-10 RSC & ERG11 3 5.88E-10
4 SGTC_2765 myclobutanil 5.65 7.7 µM 2.93E-9 azole & statin 15 8.13E-9
5 SGTC_841 0251-0215 5.57 91.2 µM 4.58E-9 43 1.24E-8
6 SGTC_2008 4012253 5.28 172.0 µM 2.69E-8 3 6.62E-8
7 SGTC_2996 9066192 5.09 71.4 µM 7.67E-8 9 1.78E-7
8 SGTC_2433 5607874 4.69 27.8 µM 6.61E-7 9 1.36E-6
9 SGTC_839 0122-0028 4.64 230.0 µM 8.36E-7 RSC complex & mRNA processing 20 1.70E-6
10 SGTC_353 1988-1175 4.35 58.3 µM 3.64E-6 unfolded protein response 19 6.83E-6
11 SGTC_956 1185-0240 4.13 191.0 µM 1.03E-5 20 1.83E-5
12 SGTC_1028 k015-0029 4.09 4.8 µM 1.23E-5 22 2.16E-5
13 SGTC_2630 antimycin a 4.03 100.0 µM 1.59E-5 mitochondrial processes 37 2.75E-5
14 SGTC_206 4546-0025 3.99 72.0 µM 1.91E-5 NEO1 70 3.28E-5
15 SGTC_1965 Pectolinarigenin 3.99 58.4 µM 1.96E-5 RPP1 & pyrimidine depletion 14 3.35E-5
16 SGTC_1504 k297-0033 3.80 30.0 µM 4.42E-5 17 7.23E-5
17 SGTC_997 3996-0078 3.76 137.0 µM 5.26E-5 30 8.53E-5
18 SGTC_2993 9054257 3.69 71.4 µM 7.12E-5 fatty acid desaturase (OLE1) 54 1.14E-4
19 SGTC_2262 9014885 3.65 67.5 µM 8.22E-5 8 1.30E-4
20 SGTC_2983 9022671 3.64 13.0 µM 8.53E-5 60S ribosome export 20 1.35E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 8.30E-18 YDR419W RAD30 hom DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV
0.102 4.09E-9 YKR078W YKR078W hom Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)
0.091 1.20E-7 YGR279C SCW4 hom Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
0.089 2.37E-7 YOL111C MDY2 hom Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes
0.089 2.50E-7 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.087 4.97E-7 YLR184W_d YLR184W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.084 1.05E-6 YIL016W SNL1 hom Ribosome-associated protein proposed to act in protein synthesis and nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein
0.080 3.10E-6 YKR031C SPO14 hom Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.079 5.24E-6 YEL038W UTR4 hom Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus
0.078 5.34E-6 YOR172W YRM1 hom Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes
0.072 2.82E-5 YBR248C HIS7 hom Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor
0.071 3.87E-5 YER135C_d YER135C_d hom Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene
0.071 4.30E-5 YLL058W_p YLL058W_p hom Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene
0.070 4.41E-5 YOL107W_p YOL107W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein
0.069 6.18E-5 YGL078C DBP3 hom RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype