YPR201W / ARR3

Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR201W / ARR3

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-4.22|P-value:5.19E-6 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.05|P-value:7.27E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.14|P-value:4.78E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.45|P-value:1.42E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.30|P-value:3.02E-6 ID:SGTC_493|Compound:zm226600|FD-Score:3.01|P-value:7.64E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:3.12|P-value:5.06E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:-3.20|P-value:4.23E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:-3.14|P-value:5.26E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:4.23|P-value:4.40E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:5.87|P-value:3.38E-10 ID:SGTC_954|Compound:1189-0853|FD-Score:3.32|P-value:2.39E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:4.04|P-value:1.09E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.31|P-value:2.50E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.04|P-value:6.79E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.56|P-value:9.06E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:2.95|P-value:9.39E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.52|P-value:1.06E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.20|P-value:3.82E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:3.25|P-value:3.16E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.31|P-value:2.46E-4 ID:SGTC_1608|Compound:st001473|FD-Score:3.94|P-value:1.68E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.36|P-value:1.99E-4 ID:SGTC_1654|Compound:st012436|FD-Score:4.51|P-value:1.05E-6 ID:SGTC_1713|Compound:st033146|FD-Score:4.53|P-value:9.48E-7 ID:SGTC_1727|Compound:st034309|FD-Score:3.27|P-value:2.91E-4 ID:SGTC_1846|Compound:st056244|FD-Score:2.94|P-value:9.68E-4 ID:SGTC_1859|Compound:st055998|FD-Score:6.99|P-value:1.08E-13 ID:SGTC_1891|Compound:st059073|FD-Score:-3.41|P-value:1.86E-4 ID:SGTC_1892|Compound:st058411|FD-Score:4.06|P-value:9.66E-6 ID:SGTC_1915|Compound:st067105|FD-Score:2.94|P-value:9.75E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.17|P-value:4.24E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.20|P-value:3.76E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.22|P-value:3.46E-4 ID:SGTC_2109|Compound:5483026|FD-Score:-3.30|P-value:2.93E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.19|P-value:4.35E-4 ID:SGTC_2228|Compound:7354201|FD-Score:3.23|P-value:3.36E-4 ID:SGTC_2323|Compound:6148992|FD-Score:3.25|P-value:3.06E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.77|P-value:4.15E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:3.36|P-value:1.99E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.08|P-value:5.88E-4 ID:SGTC_2696|Compound:st077691|FD-Score:4.31|P-value:2.93E-6 ID:SGTC_2736|Compound:butenafine|FD-Score:3.00|P-value:7.94E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:3.15|P-value:4.62E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.82|P-value:2.98E-5 ID:SGTC_2831|Compound:7999036|FD-Score:3.11|P-value:5.23E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.04|P-value:6.89E-4 ID:SGTC_3044|Compound:9093193|FD-Score:4.38|P-value:2.07E-6 ID:SGTC_3208|Compound:9114115|FD-Score:11.40|P-value:2.44E-33 ID:SGTC_3290|Compound:9121031|FD-Score:-3.95|P-value:1.87E-5 ID:SGTC_3291|Compound:9121177|FD-Score:-3.08|P-value:6.58E-4 ID:SGTC_3293|Compound:9120939|FD-Score:-3.91|P-value:2.21E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.22|P-value:5.19E-6 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.05|P-value:7.27E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.14|P-value:4.78E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.45|P-value:1.42E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.30|P-value:3.02E-6 ID:SGTC_493|Compound:zm226600|FD-Score:3.01|P-value:7.64E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:3.12|P-value:5.06E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:-3.20|P-value:4.23E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:-3.14|P-value:5.26E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:4.23|P-value:4.40E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:5.87|P-value:3.38E-10 ID:SGTC_954|Compound:1189-0853|FD-Score:3.32|P-value:2.39E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:4.04|P-value:1.09E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.31|P-value:2.50E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.04|P-value:6.79E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.56|P-value:9.06E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:2.95|P-value:9.39E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.52|P-value:1.06E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.20|P-value:3.82E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:3.25|P-value:3.16E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.31|P-value:2.46E-4 ID:SGTC_1608|Compound:st001473|FD-Score:3.94|P-value:1.68E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.36|P-value:1.99E-4 ID:SGTC_1654|Compound:st012436|FD-Score:4.51|P-value:1.05E-6 ID:SGTC_1713|Compound:st033146|FD-Score:4.53|P-value:9.48E-7 ID:SGTC_1727|Compound:st034309|FD-Score:3.27|P-value:2.91E-4 ID:SGTC_1846|Compound:st056244|FD-Score:2.94|P-value:9.68E-4 ID:SGTC_1859|Compound:st055998|FD-Score:6.99|P-value:1.08E-13 ID:SGTC_1891|Compound:st059073|FD-Score:-3.41|P-value:1.86E-4 ID:SGTC_1892|Compound:st058411|FD-Score:4.06|P-value:9.66E-6 ID:SGTC_1915|Compound:st067105|FD-Score:2.94|P-value:9.75E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.17|P-value:4.24E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.20|P-value:3.76E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.22|P-value:3.46E-4 ID:SGTC_2109|Compound:5483026|FD-Score:-3.30|P-value:2.93E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.19|P-value:4.35E-4 ID:SGTC_2228|Compound:7354201|FD-Score:3.23|P-value:3.36E-4 ID:SGTC_2323|Compound:6148992|FD-Score:3.25|P-value:3.06E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.77|P-value:4.15E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:3.36|P-value:1.99E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.08|P-value:5.88E-4 ID:SGTC_2696|Compound:st077691|FD-Score:4.31|P-value:2.93E-6 ID:SGTC_2736|Compound:butenafine|FD-Score:3.00|P-value:7.94E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:3.15|P-value:4.62E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.82|P-value:2.98E-5 ID:SGTC_2831|Compound:7999036|FD-Score:3.11|P-value:5.23E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.04|P-value:6.89E-4 ID:SGTC_3044|Compound:9093193|FD-Score:4.38|P-value:2.07E-6 ID:SGTC_3208|Compound:9114115|FD-Score:11.40|P-value:2.44E-33 ID:SGTC_3290|Compound:9121031|FD-Score:-3.95|P-value:1.87E-5 ID:SGTC_3291|Compound:9121177|FD-Score:-3.08|P-value:6.58E-4 ID:SGTC_3293|Compound:9120939|FD-Score:-3.91|P-value:2.21E-5

Top fitness defect scores for YPR201W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3208 9114115 11.40 49.5 µM 2.44E-33 1 1.88E-30
2 SGTC_1859 st055998 6.99 20.0 µM 1.08E-13 3 1.40E-12
3 SGTC_708 3448-5400 5.87 146.0 µM 3.38E-10 10 2.13E-9
4 SGTC_1713 st033146 4.53 12.8 µM 9.48E-7 16 2.95E-6
5 SGTC_1654 st012436 4.51 41.8 µM 1.05E-6 12 3.24E-6
6 SGTC_3044 9093193 4.38 49.5 µM 2.07E-6 18 5.99E-6
7 SGTC_2696 st077691 4.31 74.3 µM 2.93E-6 20 8.24E-6
8 SGTC_391 gliotoxin 4.30 8.3 µM 3.02E-6 49 8.45E-6
9 SGTC_619 1652-1634 4.23 108.0 µM 4.40E-6 PDR1 16 1.19E-5
10 SGTC_1892 st058411 4.06 7.4 µM 9.66E-6 17 2.44E-5
11 SGTC_1272 0839-0021 4.04 27.0 µM 1.09E-5 15 2.73E-5
12 SGTC_1608 st001473 3.94 40.5 µM 1.68E-5 35 4.05E-5
13 SGTC_2776 terbinafine 3.82 19.9 µM 2.98E-5 cell wall signaling 58 6.80E-5
14 SGTC_1307 1187-1599 3.56 12.2 µM 9.06E-5 PDR1 19 1.88E-4
15 SGTC_1505 k297-0037 3.52 20.6 µM 1.06E-4 30 2.17E-4
16 SGTC_237 nikkomycin 3.45 200.0 µM 1.42E-4 RSC complex & mRNA processing 29 2.82E-4
17 SGTC_1611 st001856 3.36 99.4 µM 1.99E-4 37 3.84E-4
18 SGTC_2507 purpurin 3.36 79.7 µM 1.99E-4 copper-dependent oxidative stress 60 3.85E-4
19 SGTC_954 1189-0853 3.32 2.9 µM 2.39E-4 endomembrane recycling 64 4.54E-4
20 SGTC_1605 st000082 3.31 49.1 µM 2.46E-4 60S ribosome export 39 4.67E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 9.82E-14 YJL077C ICS3 hom Protein of unknown function; may play a role in vacuolar sorting, null mutants are hypersensitive to sortin2
0.121 1.71E-12 YGL210W YPT32 hom Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication
0.107 5.09E-10 YNL310C ZIM17 het Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix
0.105 1.23E-9 YNL339C YRF1-6 hom Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
0.102 2.76E-9 YGR128C UTP8 het Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.102 3.20E-9 YPR054W SMK1 hom Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p
0.102 3.46E-9 YOL032W OPI10 hom Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress
0.101 4.80E-9 YER101C AST2 hom Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication
0.100 5.81E-9 YNL327W EGT2 hom Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
0.098 1.22E-8 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.097 1.53E-8 YMR149W SWP1 het Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum
0.092 9.95E-8 YER178W PDA1 hom E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose
0.090 1.77E-7 YJL205C NCE101 hom Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences
0.086 5.62E-7 YCL048W SPS22 hom Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
0.085 7.66E-7 YGR001C_p YGR001C_p hom Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae