Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YOR294W | 8.04 | 4.37E-16 | 2.13 | RRS1 | Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice |
YJR065C | 5.91 | 1.70E-9 | 0.62 | ARP3 | Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity |
YHR170W | 5.29 | 6.16E-8 | 0.02 | NMD3 | Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex |
YGL150C | 5.27 | 6.69E-8 | 0.97 | INO80 | ATPase and nucleosome spacing factor, subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription |
YDR232W | 4.30 | 8.57E-6 | 0.15 | HEM1 | 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p |
YGL099W | 4.14 | 1.70E-5 | 0.33 | LSG1 | Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm |
YDL212W | 3.81 | 6.95E-5 | 0.26 | SHR3 | Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface |
YJL072C | 3.55 | 1.93E-4 | 0.09 | PSF2 | Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery |
YOL078W | 3.46 | 2.68E-4 | 0.11 | AVO1 | Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth |
YNL306W | 3.35 | 3.99E-4 | 0.02 | MRPS18 | Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins |
YAL003W | 3.34 | 4.23E-4 | 0.02 | EFB1 | Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site |
YJL173C | 3.31 | 4.58E-4 | 0.07 | RFA3 | Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress |
YER146W | 3.25 | 5.84E-4 | 0.01 | LSM5 | Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA |
YBL074C | 3.24 | 6.03E-4 | 0.02 | AAR2 | Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron |
YDR180W | 3.21 | 6.52E-4 | 0.01 | SCC2 | Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin |