4112-3522

5-[2-(4-chloroanilino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-amine

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1012
Screen concentration 18.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 3112398
SMILES CC1=C(SC(=N1)N)C2=CSC(=N2)NC3=CC=C(C=C3)Cl
Standardized SMILES Cc1nc(N)sc1c2csc(Nc3ccc(Cl)cc3)n2
Molecular weight 322.8362
ALogP 3.81
H-bond donor count 2
H-bond acceptor count 6
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.12
% growth inhibition (Hom. pool) 2.46


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 3112398
Download HIP data (tab-delimited text)  (excel)
Gene:ARP3(YJR065C)|FD-Score:6.69|P-value:1.12E-11|Clearance:1.62||SGD DESC:Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity Gene:CCT8(YJL008C)|FD-Score:3.24|P-value:5.95E-4|Clearance:0.21||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:DBP10(YDL031W)|FD-Score:-3.35|P-value:4.01E-4|Clearance:0||SGD DESC:Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis Gene:GPN3(YLR243W_p)|FD-Score:3.27|P-value:5.41E-4|Clearance:0.03||SGD DESC:Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p Gene:HEM1(YDR232W)|FD-Score:3.71|P-value:1.02E-4|Clearance:0.21||SGD DESC:5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p Gene:HRR25(YPL204W)|FD-Score:3.5|P-value:2.29E-4|Clearance:0.23||SGD DESC:Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta) Gene:MPS1(YDL028C)|FD-Score:-3.11|P-value:9.27E-4|Clearance:0||SGD DESC:Dual-specificity kinase; required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p Gene:RPC37(YKR025W)|FD-Score:3.27|P-value:5.33E-4|Clearance:0||SGD DESC:RNA polymerase III subunit C37 Gene:SEC62(YPL094C)|FD-Score:5.33|P-value:4.83E-8|Clearance:1.62||SGD DESC:Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SRP14(YDL092W)|FD-Score:-3.78|P-value:7.69E-5|Clearance:0||SGD DESC:Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14 Gene:SUB2(YDL084W)|FD-Score:-3.27|P-value:5.35E-4|Clearance:0||SGD DESC:Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:ARP3(YJR065C)|FD-Score:6.69|P-value:1.12E-11|Clearance:1.62||SGD DESC:Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity Gene:CCT8(YJL008C)|FD-Score:3.24|P-value:5.95E-4|Clearance:0.21||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:DBP10(YDL031W)|FD-Score:-3.35|P-value:4.01E-4|Clearance:0||SGD DESC:Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis Gene:GPN3(YLR243W_p)|FD-Score:3.27|P-value:5.41E-4|Clearance:0.03||SGD DESC:Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p Gene:HEM1(YDR232W)|FD-Score:3.71|P-value:1.02E-4|Clearance:0.21||SGD DESC:5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p Gene:HRR25(YPL204W)|FD-Score:3.5|P-value:2.29E-4|Clearance:0.23||SGD DESC:Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta) Gene:MPS1(YDL028C)|FD-Score:-3.11|P-value:9.27E-4|Clearance:0||SGD DESC:Dual-specificity kinase; required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p Gene:RPC37(YKR025W)|FD-Score:3.27|P-value:5.33E-4|Clearance:0||SGD DESC:RNA polymerase III subunit C37 Gene:SEC62(YPL094C)|FD-Score:5.33|P-value:4.83E-8|Clearance:1.62||SGD DESC:Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SRP14(YDL092W)|FD-Score:-3.78|P-value:7.69E-5|Clearance:0||SGD DESC:Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14 Gene:SUB2(YDL084W)|FD-Score:-3.27|P-value:5.35E-4|Clearance:0||SGD DESC:Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 3112398
Download HOP data (tab-delimited text)  (excel)
Gene:AEP2(YMR282C)|FD-Score:3.95|P-value:3.95E-5||SGD DESC:Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader Gene:AIM32(YML050W)|FD-Score:-3.63|P-value:1.40E-4||SGD DESC:Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss Gene:ARL1(YBR164C)|FD-Score:6.17|P-value:3.43E-10||SGD DESC:Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor Gene:ATG18(YFR021W)|FD-Score:3.12|P-value:8.92E-4||SGD DESC:Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood Gene:BNI1(YNL271C)|FD-Score:4.38|P-value:6.07E-6||SGD DESC:Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 Gene:BST1(YFL025C)|FD-Score:3.2|P-value:6.77E-4||SGD DESC:GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules Gene:BUD19(YJL188C_d)|FD-Score:-3.46|P-value:2.74E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:CLN1(YMR199W)|FD-Score:4.51|P-value:3.23E-6||SGD DESC:G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) Gene:CPR7(YJR032W)|FD-Score:3.21|P-value:6.54E-4||SGD DESC:Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity Gene:CTF4(YPR135W)|FD-Score:3.56|P-value:1.84E-4||SGD DESC:Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion Gene:CTR9(YOL145C)|FD-Score:3.45|P-value:2.77E-4||SGD DESC:Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats Gene:ERI1(YPL096C-A)|FD-Score:3.86|P-value:5.69E-5||SGD DESC:Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein Gene:ETR1(YBR026C)|FD-Score:3.67|P-value:1.20E-4||SGD DESC:2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis Gene:GIM5(YML094W)|FD-Score:4.98|P-value:3.26E-7||SGD DESC:Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it Gene:GPG1(YGL121C)|FD-Score:3.41|P-value:3.27E-4||SGD DESC:Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing Gene:GUP1(YGL084C)|FD-Score:5.99|P-value:1.07E-9||SGD DESC:Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport Gene:HSV2(YGR223C)|FD-Score:3.42|P-value:3.12E-4||SGD DESC:Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization Gene:HXT14(YNL318C)|FD-Score:3.29|P-value:5.06E-4||SGD DESC:Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:HXT3(YDR345C)|FD-Score:-3.72|P-value:9.91E-5||SGD DESC:Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication Gene:ILV1(YER086W)|FD-Score:5.12|P-value:1.56E-7||SGD DESC:Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation Gene:IMA5(YJL216C)|FD-Score:3.51|P-value:2.21E-4||SGD DESC:Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose Gene:IPK1(YDR315C)|FD-Score:-5.19|P-value:1.06E-7||SGD DESC:Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable Gene:LDB19(YOR322C)|FD-Score:6.4|P-value:7.75E-11||SGD DESC:Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane; null mutant has reduced affinity for alcian blue dye Gene:LEM3(YNL323W)|FD-Score:3.34|P-value:4.23E-4||SGD DESC:Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane Gene:MCM16(YPR046W)|FD-Score:3.43|P-value:3.06E-4||SGD DESC:Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3 Gene:MSR1(YHR091C)|FD-Score:5.04|P-value:2.37E-7||SGD DESC:Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6 Gene:MTC2(YKL098W)|FD-Score:6.27|P-value:1.84E-10||SGD DESC:Protein of unknown function; mtc2 is synthetically sick with cdc13-1 Gene:NPP1(YCR026C)|FD-Score:3.99|P-value:3.29E-5||SGD DESC:Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP1 has a paralog, NPP2, that arose from the whole genome duplication Gene:OPT1(YJL212C)|FD-Score:5.45|P-value:2.52E-8||SGD DESC:Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family Gene:PAF1(YBR279W)|FD-Score:4.57|P-value:2.42E-6||SGD DESC:Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1 Gene:PEX2(YJL210W)|FD-Score:4.21|P-value:1.30E-5||SGD DESC:RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import Gene:QDR3(YBR043C)|FD-Score:3.5|P-value:2.32E-4||SGD DESC:Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin Gene:RDL1(YOR285W)|FD-Score:3.18|P-value:7.39E-4||SGD DESC:Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress Gene:RIM15(YFL033C)|FD-Score:4.01|P-value:3.02E-5||SGD DESC:Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase Gene:RML2(YEL050C)|FD-Score:-3.24|P-value:6.07E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor Gene:RMT2(YDR465C)|FD-Score:-3.44|P-value:2.92E-4||SGD DESC:Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress Gene:RPL20A(YMR242C)|FD-Score:3.12|P-value:9.04E-4||SGD DESC:Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication Gene:RPL31B(YLR406C)|FD-Score:-3.55|P-value:1.95E-4||SGD DESC:Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication Gene:RTK1(YDL025C)|FD-Score:-3.29|P-value:5.08E-4||SGD DESC:Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress Gene:RTR1(YER139C)|FD-Score:3.39|P-value:3.44E-4||SGD DESC:CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication Gene:RTT103(YDR289C)|FD-Score:3.16|P-value:7.83E-4||SGD DESC:Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition Gene:SAL1(YNL083W)|FD-Score:-3.76|P-value:8.63E-5||SGD DESC:ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains Gene:SHC1(YER096W)|FD-Score:3.4|P-value:3.36E-4||SGD DESC:Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication Gene:SHE10(YGL228W)|FD-Score:3.39|P-value:3.45E-4||SGD DESC:Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest Gene:SKY1(YMR216C)|FD-Score:9.2|P-value:1.75E-20||SGD DESC:SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 Gene:SLF1(YDR515W)|FD-Score:-3.8|P-value:7.11E-5||SGD DESC:RNA binding protein that associates with polysomes; may be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts; SLF1 has a paralog, SRO9, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:SLT2(YHR030C)|FD-Score:3.38|P-value:3.64E-4||SGD DESC:Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway Gene:SSD1(YDR293C)|FD-Score:4.16|P-value:1.59E-5||SGD DESC:Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function Gene:TOM5(YPR133W-A)|FD-Score:5.02|P-value:2.56E-7||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore Gene:TRK1(YJL129C)|FD-Score:-3.88|P-value:5.14E-5||SGD DESC:Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication Gene:YBL062W(YBL062W_d)|FD-Score:4.56|P-value:2.52E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YBR027C(YBR027C_d)|FD-Score:5.39|P-value:3.46E-8||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YBR053C(YBR053C_p)|FD-Score:4.4|P-value:5.29E-6||SGD DESC:Putative protein of unknown function; induced by cell wall perturbation Gene:YCR023C(YCR023C)|FD-Score:-3.24|P-value:6.08E-4||SGD DESC:Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene Gene:YET1(YKL065C)|FD-Score:3.57|P-value:1.80E-4||SGD DESC:Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein Gene:YGL217C(YGL217C_d)|FD-Score:3.68|P-value:1.16E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W Gene:YGR079W(YGR079W_p)|FD-Score:3.59|P-value:1.63E-4||SGD DESC:Putative protein of unknown function; YGR079W is not an essential gene Gene:YGR226C(YGR226C_d)|FD-Score:-3.56|P-value:1.86E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W Gene:YHP1(YDR451C)|FD-Score:-3.63|P-value:1.44E-4||SGD DESC:Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication Gene:YJR018W(YJR018W_d)|FD-Score:3.49|P-value:2.42E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YKR041W(YKR041W)|FD-Score:4.75|P-value:1.01E-6||SGD DESC:Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking Gene:YLR012C(YLR012C_p)|FD-Score:4.8|P-value:7.99E-7||SGD DESC:Putative protein of unknown function; YLR012C is not an essential gene Gene:YMR175W-A(YMR175W-A_p)|FD-Score:4.59|P-value:2.20E-6||SGD DESC:Putative protein of unknown function Gene:YNR021W(YNR021W_p)|FD-Score:3.21|P-value:6.61E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene Gene:YOR121C(YOR121C_d)|FD-Score:4.14|P-value:1.74E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W Gene:AEP2(YMR282C)|FD-Score:3.95|P-value:3.95E-5||SGD DESC:Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader Gene:AIM32(YML050W)|FD-Score:-3.63|P-value:1.40E-4||SGD DESC:Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss Gene:ARL1(YBR164C)|FD-Score:6.17|P-value:3.43E-10||SGD DESC:Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor Gene:ATG18(YFR021W)|FD-Score:3.12|P-value:8.92E-4||SGD DESC:Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood Gene:BNI1(YNL271C)|FD-Score:4.38|P-value:6.07E-6||SGD DESC:Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 Gene:BST1(YFL025C)|FD-Score:3.2|P-value:6.77E-4||SGD DESC:GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules Gene:BUD19(YJL188C_d)|FD-Score:-3.46|P-value:2.74E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:CLN1(YMR199W)|FD-Score:4.51|P-value:3.23E-6||SGD DESC:G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) Gene:CPR7(YJR032W)|FD-Score:3.21|P-value:6.54E-4||SGD DESC:Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity Gene:CTF4(YPR135W)|FD-Score:3.56|P-value:1.84E-4||SGD DESC:Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion Gene:CTR9(YOL145C)|FD-Score:3.45|P-value:2.77E-4||SGD DESC:Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats Gene:ERI1(YPL096C-A)|FD-Score:3.86|P-value:5.69E-5||SGD DESC:Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein Gene:ETR1(YBR026C)|FD-Score:3.67|P-value:1.20E-4||SGD DESC:2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis Gene:GIM5(YML094W)|FD-Score:4.98|P-value:3.26E-7||SGD DESC:Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it Gene:GPG1(YGL121C)|FD-Score:3.41|P-value:3.27E-4||SGD DESC:Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing Gene:GUP1(YGL084C)|FD-Score:5.99|P-value:1.07E-9||SGD DESC:Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport Gene:HSV2(YGR223C)|FD-Score:3.42|P-value:3.12E-4||SGD DESC:Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization Gene:HXT14(YNL318C)|FD-Score:3.29|P-value:5.06E-4||SGD DESC:Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:HXT3(YDR345C)|FD-Score:-3.72|P-value:9.91E-5||SGD DESC:Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication Gene:ILV1(YER086W)|FD-Score:5.12|P-value:1.56E-7||SGD DESC:Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation Gene:IMA5(YJL216C)|FD-Score:3.51|P-value:2.21E-4||SGD DESC:Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose Gene:IPK1(YDR315C)|FD-Score:-5.19|P-value:1.06E-7||SGD DESC:Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable Gene:LDB19(YOR322C)|FD-Score:6.4|P-value:7.75E-11||SGD DESC:Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane; null mutant has reduced affinity for alcian blue dye Gene:LEM3(YNL323W)|FD-Score:3.34|P-value:4.23E-4||SGD DESC:Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane Gene:MCM16(YPR046W)|FD-Score:3.43|P-value:3.06E-4||SGD DESC:Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3 Gene:MSR1(YHR091C)|FD-Score:5.04|P-value:2.37E-7||SGD DESC:Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6 Gene:MTC2(YKL098W)|FD-Score:6.27|P-value:1.84E-10||SGD DESC:Protein of unknown function; mtc2 is synthetically sick with cdc13-1 Gene:NPP1(YCR026C)|FD-Score:3.99|P-value:3.29E-5||SGD DESC:Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP1 has a paralog, NPP2, that arose from the whole genome duplication Gene:OPT1(YJL212C)|FD-Score:5.45|P-value:2.52E-8||SGD DESC:Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family Gene:PAF1(YBR279W)|FD-Score:4.57|P-value:2.42E-6||SGD DESC:Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1 Gene:PEX2(YJL210W)|FD-Score:4.21|P-value:1.30E-5||SGD DESC:RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import Gene:QDR3(YBR043C)|FD-Score:3.5|P-value:2.32E-4||SGD DESC:Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin Gene:RDL1(YOR285W)|FD-Score:3.18|P-value:7.39E-4||SGD DESC:Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress Gene:RIM15(YFL033C)|FD-Score:4.01|P-value:3.02E-5||SGD DESC:Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase Gene:RML2(YEL050C)|FD-Score:-3.24|P-value:6.07E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor Gene:RMT2(YDR465C)|FD-Score:-3.44|P-value:2.92E-4||SGD DESC:Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress Gene:RPL20A(YMR242C)|FD-Score:3.12|P-value:9.04E-4||SGD DESC:Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication Gene:RPL31B(YLR406C)|FD-Score:-3.55|P-value:1.95E-4||SGD DESC:Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication Gene:RTK1(YDL025C)|FD-Score:-3.29|P-value:5.08E-4||SGD DESC:Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress Gene:RTR1(YER139C)|FD-Score:3.39|P-value:3.44E-4||SGD DESC:CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication Gene:RTT103(YDR289C)|FD-Score:3.16|P-value:7.83E-4||SGD DESC:Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition Gene:SAL1(YNL083W)|FD-Score:-3.76|P-value:8.63E-5||SGD DESC:ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains Gene:SHC1(YER096W)|FD-Score:3.4|P-value:3.36E-4||SGD DESC:Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication Gene:SHE10(YGL228W)|FD-Score:3.39|P-value:3.45E-4||SGD DESC:Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest Gene:SKY1(YMR216C)|FD-Score:9.2|P-value:1.75E-20||SGD DESC:SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 Gene:SLF1(YDR515W)|FD-Score:-3.8|P-value:7.11E-5||SGD DESC:RNA binding protein that associates with polysomes; may be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts; SLF1 has a paralog, SRO9, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:SLT2(YHR030C)|FD-Score:3.38|P-value:3.64E-4||SGD DESC:Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway Gene:SSD1(YDR293C)|FD-Score:4.16|P-value:1.59E-5||SGD DESC:Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function Gene:TOM5(YPR133W-A)|FD-Score:5.02|P-value:2.56E-7||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore Gene:TRK1(YJL129C)|FD-Score:-3.88|P-value:5.14E-5||SGD DESC:Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication Gene:YBL062W(YBL062W_d)|FD-Score:4.56|P-value:2.52E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YBR027C(YBR027C_d)|FD-Score:5.39|P-value:3.46E-8||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YBR053C(YBR053C_p)|FD-Score:4.4|P-value:5.29E-6||SGD DESC:Putative protein of unknown function; induced by cell wall perturbation Gene:YCR023C(YCR023C)|FD-Score:-3.24|P-value:6.08E-4||SGD DESC:Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene Gene:YET1(YKL065C)|FD-Score:3.57|P-value:1.80E-4||SGD DESC:Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein Gene:YGL217C(YGL217C_d)|FD-Score:3.68|P-value:1.16E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W Gene:YGR079W(YGR079W_p)|FD-Score:3.59|P-value:1.63E-4||SGD DESC:Putative protein of unknown function; YGR079W is not an essential gene Gene:YGR226C(YGR226C_d)|FD-Score:-3.56|P-value:1.86E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W Gene:YHP1(YDR451C)|FD-Score:-3.63|P-value:1.44E-4||SGD DESC:Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication Gene:YJR018W(YJR018W_d)|FD-Score:3.49|P-value:2.42E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YKR041W(YKR041W)|FD-Score:4.75|P-value:1.01E-6||SGD DESC:Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking Gene:YLR012C(YLR012C_p)|FD-Score:4.8|P-value:7.99E-7||SGD DESC:Putative protein of unknown function; YLR012C is not an essential gene Gene:YMR175W-A(YMR175W-A_p)|FD-Score:4.59|P-value:2.20E-6||SGD DESC:Putative protein of unknown function Gene:YNR021W(YNR021W_p)|FD-Score:3.21|P-value:6.61E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene Gene:YOR121C(YOR121C_d)|FD-Score:4.14|P-value:1.74E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YJR065C6.691.12E-111.62ARP3Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
YPL094C5.334.83E-81.62SEC62Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YDR232W3.711.02E-40.21HEM15-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
YPL204W3.502.29E-40.23HRR25Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)
YKR025W3.275.33E-40.00RPC37RNA polymerase III subunit C37
YLR243W_p3.275.41E-40.03GPN3_pPutative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
YJL008C3.245.95E-40.21CCT8Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YJL072C3.030.001210.05PSF2Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
YBR049C2.980.001439.47E-4REB1RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; REB1 has a paralog, NSI1, that arose from the whole genome duplication
YEL058W2.980.001430.04PCM1Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
YMR288W2.940.001650.04HSH155U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155
YOR046C2.900.001880.05DBP5Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus; involved in translation termination; ATP/ADP cycling is regulated by Gle1p and Nup159p
YJL054W2.850.002210.06TIM54Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
YKL060C2.790.002680.00FBA1Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress
YPL043W2.780.002700.05NOP4Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YMR216C9.201.75E-20SKY1SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1
YOR322C6.407.75E-11LDB19Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane; null mutant has reduced affinity for alcian blue dye
YKL098W6.271.84E-10MTC2Protein of unknown function; mtc2 is synthetically sick with cdc13-1
YBR164C6.173.43E-10ARL1Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
YGL084C5.991.07E-9GUP1Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport
YJL212C5.452.52E-8OPT1Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
YBR027C_d5.393.46E-8YBR027C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER086W5.121.56E-7ILV1Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
YHR091C5.042.37E-7MSR1Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6
YPR133W-A5.022.56E-7TOM5Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore
YML094W4.983.26E-7GIM5Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
YLR012C_p4.807.99E-7YLR012C_pPutative protein of unknown function; YLR012C is not an essential gene
YKR041W4.751.01E-6YKR041WProtein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking
YMR175W-A_p4.592.20E-6YMR175W-A_pPutative protein of unknown function
YBR279W4.572.42E-6PAF1Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1

GO enrichment analysis for SGTC_1012
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.0896.82E-12SGTC_21925915882 198.5 μMChembridge (Fragment library)28761490.0757576RNA processing & uracil transport
0.0872.29E-11SGTC_10104112-3296 15.2 μMChemDiv (Drug-like library)7043840.283333
0.0764.13E-9SGTC_31229126309 49.5 μMChembridge (Drug-like library)175912060.0921053cell wall signaling
0.0741.13E-8SGTC_31149122766 49.5 μMChembridge (Drug-like library)171769850.0909091
0.0732.09E-8SGTC_1668st014914 51.6 μMTimTec (Natural product derivative library)28395560.0617284RPP1 & pyrimidine depletion
0.0672.61E-7SGTC_2550chrysin dimethyl ether 71.9 μMMicrosource (Natural product library)888810.0555556
0.0654.72E-7SGTC_9143820-6779 408.0 μMChemDiv (Drug-like library)28934810.111111
0.0647.38E-7SGTC_8630466-0191 129.0 μMChemDiv (Drug-like library)7651600.0882353cell wall
0.0631.28E-6SGTC_15447-methoxy-4-methylcoumarin 105.0 μMTimTec (Pure natural product library)3908070.078125
0.0631.40E-6SGTC_30749116018 49.5 μMChembridge (Drug-like library)170273030.103896RNA processing & uracil transport
0.0621.60E-6SGTC_28909046729 58.4 μMChembridge (Drug-like library)9033290.151515Golgi
0.0621.76E-6SGTC_22867945697 125.0 μMChembridge (Fragment library)12457330.126761
0.0612.82E-6SGTC_171k064-0041 9.7 μMChemDiv (Drug-like library)533250.118644heme requiring
0.0612.80E-6SGTC_6023130-1533 38.1 μMChemDiv (Drug-like library)7209410.1875
0.0612.86E-6SGTC_23427990637 118.9 μMChembridge (Fragment library)20331020.056338RNA processing & uracil transport

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_14444112-358128 μM0.4814812877249ChemDiv (Drug-like library)303.402523.37226
SGTC_1524469-0003551.23 μM0.392157697280ChemDiv (Drug-like library)268.333584.08224
SGTC_6281636-025316 μM0.3921574456143ChemDiv (Drug-like library)331.230245.07213sphingolipid biosynthesis & PDR1
SGTC_14434112-330314 μM0.375704433ChemDiv (Drug-like library)296.390043.76415
SGTC_14764112-32943.34 μM0.37037704369ChemDiv (Drug-like library)332.21834.351460S ribosome export
SGTC_14954469-0029237 μM0.368421793680ChemDiv (Drug-like library)337.440342.98227
SGTC_14424112-32903 μM0.350877704353ChemDiv (Drug-like library)267.348824.08814
SGTC_8024112-3352742 μM0.338983704594ChemDiv (Drug-like library)267.348823.65914
SGTC_13501495-0454146 μM0.3333331069057ChemDiv (Drug-like library)350.843043.92615
SGTC_9923909-8734162 μM0.3214294288319ChemDiv (Drug-like library)275.75664.01114