Deletion Strain | FD score | P-value | Gene | Gene Description |
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YLR122C_d | 8.26 | 7.09E-17 | YLR122C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C |
YPR197C_d | 6.51 | 3.74E-11 | YPR197C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YBL100W-C_p | 6.06 | 6.95E-10 | YBL100W-C_p | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
YBR069C | 5.49 | 1.99E-8 | TAT1 | Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress |
YKL033W-A_p | 5.49 | 2.05E-8 | YKL033W-A_p | Putative protein of unknown function; similar to uncharacterized proteins from other fungi |
YOR295W | 5.36 | 4.11E-8 | UAF30 | Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication |
YCR010C | 5.14 | 1.37E-7 | ADY2 | Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication |
YAL023C | 4.90 | 4.74E-7 | PMT2 | Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication |
YCR034W | 4.87 | 5.46E-7 | FEN1 | Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication |
YDR484W | 4.47 | 3.87E-6 | VPS52 | Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin |
YOR113W | 4.43 | 4.70E-6 | AZF1 | Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity |
YPL188W | 4.43 | 4.73E-6 | POS5 | Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress |
YOR133W | 4.42 | 4.83E-6 | EFT1 | Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication |
YOR072W_d | 4.29 | 9.13E-6 | YOR072W_d | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive |
YDR276C | 4.23 | 1.15E-5 | PMP3 | Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential |