Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YHR062C | 9.14 | 3.16E-20 | 3.69 | RPP1 | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs |
YOL005C | 5.45 | 2.54E-8 | 0.52 | RPB11 | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit |
YOR207C | 4.92 | 4.22E-7 | 0.14 | RET1 | Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs |
YDR437W | 4.79 | 8.53E-7 | 0.15 | GPI19 | Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P |
YCL059C | 4.64 | 1.78E-6 | 0.05 | KRR1 | Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit |
YJL014W | 4.59 | 2.25E-6 | 0.05 | CCT3 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
YCL004W | 4.54 | 2.81E-6 | 0.03 | PGS1 | Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis |
YNL088W | 4.51 | 3.23E-6 | 0.01 | TOP2 | Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation |
YOR210W | 4.50 | 3.35E-6 | 0.28 | RPB10 | RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III |
YDR527W | 4.22 | 1.23E-5 | 0.38 | RBA50 | Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1 |
YMR185W_p | 3.84 | 6.25E-5 | 0.00 | RTP1_p | Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene |
YML092C | 3.83 | 6.36E-5 | 0.10 | PRE8 | Alpha 2 subunit of the 20S proteasome |
YDL148C | 3.73 | 9.48E-5 | 0.14 | NOP14 | Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA |
YGR083C | 3.60 | 1.62E-4 | 0.09 | GCD2 | Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression |
YLR167W | 3.51 | 2.24E-4 | 0.08 | RPS31 | Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog |