Deletion Strain | FD score | P-value | Gene | Gene Description |
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YGL115W | 6.18 | 3.20E-10 | SNF4 | Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress |
YNR036C | 5.86 | 2.32E-9 | MRPS12 | Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins |
YER097W_d | 5.83 | 2.82E-9 | YER097W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YPL106C | 5.73 | 5.17E-9 | SSE1 | ATPase component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSE1 has a paralog, SSE2, that arose from the whole genome duplication |
YLR254C | 5.31 | 5.53E-8 | NDL1 | Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends |
YPR028W | 5.13 | 1.47E-7 | YOP1 | Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; forms ER foci upon DNA replication stress |
YPL048W | 5.12 | 1.52E-7 | CAM1 | Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma |
YBR200W-A_p | 4.56 | 2.53E-6 | YBR200W-A_p | Putative protein of unknown function; identified by fungal homology and RT-PCR |
YHR010W | 4.55 | 2.67E-6 | RPL27A | Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication |
YBL012C_d | 4.55 | 2.69E-6 | YBL012C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YKR003W | 4.55 | 2.74E-6 | OSH6 | Member of an oxysterol-binding protein family; overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion |
YBR015C | 4.35 | 6.86E-6 | MNN2 | Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment |
YHR163W | 4.27 | 9.68E-6 | SOL3 | 6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication |
YNL212W | 4.25 | 1.09E-5 | VID27 | Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth |
YLR287C-A | 4.17 | 1.54E-5 | RPS30A | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication |