| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YDR200C | 6.03 | 8.30E-10 | VPS64 | Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance |
| YNL228W_d | 5.78 | 3.68E-9 | YNL228W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1 |
| YKL126W | 5.66 | 7.55E-9 | YPK1 | Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication |
| YJR011C_p | 5.44 | 2.65E-8 | YJR011C_p | Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS |
| YHR108W | 5.01 | 2.72E-7 | GGA2 | Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin |
| YLR181C | 4.88 | 5.23E-7 | VTA1 | Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain |
| YDR457W | 4.86 | 6.02E-7 | TOM1 | E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase |
| YPR192W | 4.77 | 9.03E-7 | AQY1 | Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance |
| YIR020W-A_d | 4.76 | 9.76E-7 | YIR020W-A_d | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data |
| YOL016C | 4.72 | 1.17E-6 | CMK2 | Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication |
| YEL063C | 4.72 | 1.18E-6 | CAN1 | Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication |
| YOR156C | 4.65 | 1.64E-6 | NFI1 | SUMO E3 ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; primary E3 ligase for Sir4p; sumoylates Yku70p/Yku80p and Sir4p in vivo to promote chromatin anchoring; promotes telomere anchoring to the nuclear envelope; involved in maintenance of proper telomere length |
| YMR283C | 4.57 | 2.45E-6 | RIT1 | 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA |
| YHR103W | 4.44 | 4.40E-6 | SBE22 | Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth |
| YPL097W | 4.42 | 4.93E-6 | MSY1 | Mitochondrial tyrosyl-tRNA synthetase |
