0111-0055

2-(1-adamantyl)-2-bromoacetamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_105
Screen concentration 734.8 μM
Source ChemDiv (Drug-like library)
PubChem CID 5179370
SMILES C1C2CC3CC1CC(C2)(C3)C(C(=O)N)Br
Standardized SMILES NC(=O)C(Br)C12CC3CC(CC(C3)C1)C2
Molecular weight 272.1814
ALogP 2.46
H-bond donor count 1
H-bond acceptor count 1
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 7.18
% growth inhibition (Hom. pool) 4.03


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 5179370
Download HIP data (tab-delimited text)  (excel)
Gene:DED1(YOR204W)|FD-Score:-3.19|P-value:7.02E-4|Clearance:0||SGD DESC:ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility Gene:ERG12(YMR208W)|FD-Score:4.34|P-value:7.07E-6|Clearance:0.76||SGD DESC:Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate Gene:NMD3(YHR170W)|FD-Score:3.53|P-value:2.04E-4|Clearance:0.45||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:PRP5(YBR237W)|FD-Score:3.58|P-value:1.72E-4|Clearance:0.05||SGD DESC:RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA Gene:TAF11(YML015C)|FD-Score:-3.3|P-value:4.78E-4|Clearance:0||SGD DESC:TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors Gene:TAF9(YMR236W)|FD-Score:-3.3|P-value:4.84E-4|Clearance:0||SGD DESC:Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3 Gene:YLR076C(YLR076C_d)|FD-Score:4.77|P-value:9.02E-7|Clearance:0.76||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10 Gene:DED1(YOR204W)|FD-Score:-3.19|P-value:7.02E-4|Clearance:0||SGD DESC:ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility Gene:ERG12(YMR208W)|FD-Score:4.34|P-value:7.07E-6|Clearance:0.76||SGD DESC:Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate Gene:NMD3(YHR170W)|FD-Score:3.53|P-value:2.04E-4|Clearance:0.45||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:PRP5(YBR237W)|FD-Score:3.58|P-value:1.72E-4|Clearance:0.05||SGD DESC:RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA Gene:TAF11(YML015C)|FD-Score:-3.3|P-value:4.78E-4|Clearance:0||SGD DESC:TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors Gene:TAF9(YMR236W)|FD-Score:-3.3|P-value:4.84E-4|Clearance:0||SGD DESC:Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3 Gene:YLR076C(YLR076C_d)|FD-Score:4.77|P-value:9.02E-7|Clearance:0.76||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 5179370
Download HOP data (tab-delimited text)  (excel)
Gene:ACF2(YLR144C)|FD-Score:3.31|P-value:4.68E-4||SGD DESC:Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress Gene:BLM10(YFL007W)|FD-Score:3.09|P-value:9.98E-4||SGD DESC:Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200 Gene:BUD7(YOR299W)|FD-Score:-3.77|P-value:8.17E-5||SGD DESC:Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BUD7 has a paralog, BCH1, that arose from the whole genome duplication Gene:FAR11(YNL127W)|FD-Score:3.74|P-value:9.09E-5||SGD DESC:Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2 Gene:FET4(YMR319C)|FD-Score:3.2|P-value:6.81E-4||SGD DESC:Low-affinity Fe(II) transporter of the plasma membrane Gene:FMO1(YHR176W)|FD-Score:4.2|P-value:1.33E-5||SGD DESC:Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins Gene:GOT1(YMR292W)|FD-Score:-4.35|P-value:6.71E-6||SGD DESC:Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition Gene:GPB2(YAL056W)|FD-Score:3.12|P-value:8.90E-4||SGD DESC:Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication Gene:HXT17(YNR072W)|FD-Score:3.63|P-value:1.42E-4||SGD DESC:Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose Gene:ISR1(YPR106W)|FD-Score:3.33|P-value:4.27E-4||SGD DESC:Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C Gene:MSB1(YOR188W)|FD-Score:3.13|P-value:8.67E-4||SGD DESC:Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:NAP1(YKR048C)|FD-Score:-3.4|P-value:3.43E-4||SGD DESC:Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress Gene:NPC2(YDL046W)|FD-Score:-3.18|P-value:7.26E-4||SGD DESC:Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes Gene:NUP133(YKR082W)|FD-Score:3.12|P-value:9.06E-4||SGD DESC:Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP133 Gene:OSM1(YJR051W)|FD-Score:-3.14|P-value:8.31E-4||SGD DESC:Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; OSM1 has a paralog, FRD1, that arose from the whole genome duplication Gene:PTP1(YDL230W)|FD-Score:-3.78|P-value:7.74E-5||SGD DESC:Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation Gene:RAD17(YOR368W)|FD-Score:-4.34|P-value:7.00E-6||SGD DESC:Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins Gene:RAD34(YDR314C)|FD-Score:3.58|P-value:1.70E-4||SGD DESC:Protein involved in nucleotide excision repair (NER); homologous to RAD4 Gene:RGD2(YFL047W)|FD-Score:-3.73|P-value:9.64E-5||SGD DESC:GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:RKR1(YMR247C)|FD-Score:3.75|P-value:8.73E-5||SGD DESC:RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice Gene:RMD5(YDR255C)|FD-Score:-4.44|P-value:4.59E-6||SGD DESC:Component of GID Complex that confers ubiquitin ligase (U3) activity; necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; forms dimer with Fyv10p that is then recruited to GID Complex by Gid8p; also required for sporulation; conserved protein that has a degenerate RING finger domain Gene:RPL24B(YGR148C)|FD-Score:3.7|P-value:1.08E-4||SGD DESC:Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication Gene:SCO2(YBR024W)|FD-Score:3.22|P-value:6.32E-4||SGD DESC:Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication Gene:SKI3(YPR189W)|FD-Score:3.12|P-value:8.96E-4||SGD DESC:Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay Gene:SNX3(YOR357C)|FD-Score:3.41|P-value:3.31E-4||SGD DESC:Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p Gene:SPL2(YHR136C)|FD-Score:3.9|P-value:4.72E-5||SGD DESC:Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm Gene:SPT23(YKL020C)|FD-Score:3.38|P-value:3.69E-4||SGD DESC:ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting Gene:SSE1(YPL106C)|FD-Score:3.18|P-value:7.40E-4||SGD DESC:ATPase component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSE1 has a paralog, SSE2, that arose from the whole genome duplication Gene:SUT1(YGL162W)|FD-Score:-3.97|P-value:3.55E-5||SGD DESC:Transcription factor of the Zn2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:TDA6(YPR157W_p)|FD-Score:3.46|P-value:2.67E-4||SGD DESC:Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele Gene:VAN1(YML115C)|FD-Score:3.34|P-value:4.15E-4||SGD DESC:Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant Gene:VEL1(YGL258W)|FD-Score:3.83|P-value:6.53E-5||SGD DESC:Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C Gene:YAP1801(YHR161C)|FD-Score:5.71|P-value:5.74E-9||SGD DESC:Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication Gene:YAT1(YAR035W)|FD-Score:-3.82|P-value:6.74E-5||SGD DESC:Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated Gene:YBR032W(YBR032W_d)|FD-Score:3.14|P-value:8.48E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Gene:YBR178W(YBR178W_d)|FD-Score:-4.45|P-value:4.38E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C Gene:YCR064C(YCR064C_d)|FD-Score:3.3|P-value:4.91E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31 Gene:YGL177W(YGL177W_d)|FD-Score:3.1|P-value:9.71E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YML009C-A(YML009C-A_d)|FD-Score:3.26|P-value:5.65E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR052C-A(YMR052C-A_d)|FD-Score:4.09|P-value:2.13E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR119W-A(YMR119W-A_d)|FD-Score:3.18|P-value:7.49E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR242W-A(YMR242W-A_p)|FD-Score:3.24|P-value:6.01E-4||SGD DESC:Putative protein of unknown function Gene:YNR040W(YNR040W_p)|FD-Score:-3.33|P-value:4.29E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YOL118C(YOL118C_d)|FD-Score:3.76|P-value:8.54E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPL034W(YPL034W_p)|FD-Score:-3.22|P-value:6.43E-4||SGD DESC:Putative protein of unknown function; YPL034W is not essential gene Gene:YPR071W(YPR071W_p)|FD-Score:4.53|P-value:2.93E-6||SGD DESC:Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C Gene:YRM1(YOR172W)|FD-Score:3.7|P-value:1.07E-4||SGD DESC:Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes Gene:YTA6(YPL074W)|FD-Score:3.28|P-value:5.26E-4||SGD DESC:Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress Gene:ACF2(YLR144C)|FD-Score:3.31|P-value:4.68E-4||SGD DESC:Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress Gene:BLM10(YFL007W)|FD-Score:3.09|P-value:9.98E-4||SGD DESC:Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200 Gene:BUD7(YOR299W)|FD-Score:-3.77|P-value:8.17E-5||SGD DESC:Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BUD7 has a paralog, BCH1, that arose from the whole genome duplication Gene:FAR11(YNL127W)|FD-Score:3.74|P-value:9.09E-5||SGD DESC:Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2 Gene:FET4(YMR319C)|FD-Score:3.2|P-value:6.81E-4||SGD DESC:Low-affinity Fe(II) transporter of the plasma membrane Gene:FMO1(YHR176W)|FD-Score:4.2|P-value:1.33E-5||SGD DESC:Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins Gene:GOT1(YMR292W)|FD-Score:-4.35|P-value:6.71E-6||SGD DESC:Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition Gene:GPB2(YAL056W)|FD-Score:3.12|P-value:8.90E-4||SGD DESC:Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication Gene:HXT17(YNR072W)|FD-Score:3.63|P-value:1.42E-4||SGD DESC:Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose Gene:ISR1(YPR106W)|FD-Score:3.33|P-value:4.27E-4||SGD DESC:Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C Gene:MSB1(YOR188W)|FD-Score:3.13|P-value:8.67E-4||SGD DESC:Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:NAP1(YKR048C)|FD-Score:-3.4|P-value:3.43E-4||SGD DESC:Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress Gene:NPC2(YDL046W)|FD-Score:-3.18|P-value:7.26E-4||SGD DESC:Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes Gene:NUP133(YKR082W)|FD-Score:3.12|P-value:9.06E-4||SGD DESC:Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP133 Gene:OSM1(YJR051W)|FD-Score:-3.14|P-value:8.31E-4||SGD DESC:Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; OSM1 has a paralog, FRD1, that arose from the whole genome duplication Gene:PTP1(YDL230W)|FD-Score:-3.78|P-value:7.74E-5||SGD DESC:Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation Gene:RAD17(YOR368W)|FD-Score:-4.34|P-value:7.00E-6||SGD DESC:Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins Gene:RAD34(YDR314C)|FD-Score:3.58|P-value:1.70E-4||SGD DESC:Protein involved in nucleotide excision repair (NER); homologous to RAD4 Gene:RGD2(YFL047W)|FD-Score:-3.73|P-value:9.64E-5||SGD DESC:GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:RKR1(YMR247C)|FD-Score:3.75|P-value:8.73E-5||SGD DESC:RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice Gene:RMD5(YDR255C)|FD-Score:-4.44|P-value:4.59E-6||SGD DESC:Component of GID Complex that confers ubiquitin ligase (U3) activity; necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; forms dimer with Fyv10p that is then recruited to GID Complex by Gid8p; also required for sporulation; conserved protein that has a degenerate RING finger domain Gene:RPL24B(YGR148C)|FD-Score:3.7|P-value:1.08E-4||SGD DESC:Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication Gene:SCO2(YBR024W)|FD-Score:3.22|P-value:6.32E-4||SGD DESC:Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication Gene:SKI3(YPR189W)|FD-Score:3.12|P-value:8.96E-4||SGD DESC:Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay Gene:SNX3(YOR357C)|FD-Score:3.41|P-value:3.31E-4||SGD DESC:Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p Gene:SPL2(YHR136C)|FD-Score:3.9|P-value:4.72E-5||SGD DESC:Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm Gene:SPT23(YKL020C)|FD-Score:3.38|P-value:3.69E-4||SGD DESC:ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting Gene:SSE1(YPL106C)|FD-Score:3.18|P-value:7.40E-4||SGD DESC:ATPase component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSE1 has a paralog, SSE2, that arose from the whole genome duplication Gene:SUT1(YGL162W)|FD-Score:-3.97|P-value:3.55E-5||SGD DESC:Transcription factor of the Zn2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:TDA6(YPR157W_p)|FD-Score:3.46|P-value:2.67E-4||SGD DESC:Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele Gene:VAN1(YML115C)|FD-Score:3.34|P-value:4.15E-4||SGD DESC:Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant Gene:VEL1(YGL258W)|FD-Score:3.83|P-value:6.53E-5||SGD DESC:Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C Gene:YAP1801(YHR161C)|FD-Score:5.71|P-value:5.74E-9||SGD DESC:Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication Gene:YAT1(YAR035W)|FD-Score:-3.82|P-value:6.74E-5||SGD DESC:Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated Gene:YBR032W(YBR032W_d)|FD-Score:3.14|P-value:8.48E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Gene:YBR178W(YBR178W_d)|FD-Score:-4.45|P-value:4.38E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C Gene:YCR064C(YCR064C_d)|FD-Score:3.3|P-value:4.91E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31 Gene:YGL177W(YGL177W_d)|FD-Score:3.1|P-value:9.71E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YML009C-A(YML009C-A_d)|FD-Score:3.26|P-value:5.65E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR052C-A(YMR052C-A_d)|FD-Score:4.09|P-value:2.13E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR119W-A(YMR119W-A_d)|FD-Score:3.18|P-value:7.49E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR242W-A(YMR242W-A_p)|FD-Score:3.24|P-value:6.01E-4||SGD DESC:Putative protein of unknown function Gene:YNR040W(YNR040W_p)|FD-Score:-3.33|P-value:4.29E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YOL118C(YOL118C_d)|FD-Score:3.76|P-value:8.54E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPL034W(YPL034W_p)|FD-Score:-3.22|P-value:6.43E-4||SGD DESC:Putative protein of unknown function; YPL034W is not essential gene Gene:YPR071W(YPR071W_p)|FD-Score:4.53|P-value:2.93E-6||SGD DESC:Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C Gene:YRM1(YOR172W)|FD-Score:3.7|P-value:1.07E-4||SGD DESC:Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes Gene:YTA6(YPL074W)|FD-Score:3.28|P-value:5.26E-4||SGD DESC:Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YLR076C_d4.779.02E-70.76YLR076C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10
YMR208W4.347.07E-60.76ERG12Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
YBR237W3.581.72E-40.05PRP5RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA
YHR170W3.532.04E-40.45NMD3Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
YLR198C_d3.090.001010.13YLR198C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W
YBR087W2.960.001560.00RFC5Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YPL228W2.950.001590.11CET1Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
YGL099W2.840.002270.18LSG1Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
YNL287W2.650.003980.05SEC21Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
YDR280W2.610.004560.00RRP45Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
YDR288W2.600.004600.10NSE3Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress
YLR051C2.510.006050.00FCF2Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon
YHR072W2.500.006130.04ERG7Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
YFL045C2.470.006840.01SEC53Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen
YLR086W2.450.007050.03SMC4Subunit of the condensin complex; reorganizes chromosomes during cell division; forms a complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YHR161C5.715.74E-9YAP1801Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication
YPR071W_p4.532.93E-6YPR071W_pPutative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C
YHR176W4.201.33E-5FMO1Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins
YMR052C-A_d4.092.13E-5YMR052C-A_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR136C3.904.72E-5SPL2Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm
YGL258W3.836.53E-5VEL1Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C
YOL118C_d3.768.54E-5YOL118C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR247C3.758.73E-5RKR1RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice
YNL127W3.749.09E-5FAR11Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2
YOR172W3.701.07E-4YRM1Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes
YGR148C3.701.08E-4RPL24BRibosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication
YNR072W3.631.42E-4HXT17Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose
YDR314C3.581.70E-4RAD34Protein involved in nucleotide excision repair (NER); homologous to RAD4
YPR157W_p3.462.67E-4TDA6_pPutative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele
YOR357C3.413.31E-4SNX3Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p

GO enrichment analysis for SGTC_105
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0731.90E-8SGTC_29279011802 47.9 μMChembridge (Drug-like library)439125680.0517241
0.0706.19E-8SGTC_1947st076332 61.6 μMTimTec (Natural product derivative library)242084160.0142857
0.0708.43E-8SGTC_6330437-0093 97.7 μMChemDiv (Drug-like library)28311180.0519481DNA intercalators
0.0681.53E-7SGTC_5794491-1009 110.0 μMChemDiv (Drug-like library)1271041NA60S ribosome export
0.0631.47E-6SGTC_28187996756 13.0 μMChembridge (Drug-like library)22416210.0447761
0.0621.81E-6SGTC_1060092-0003 11.6 μMChemDiv (Drug-like library)10721480.08copper-dependent oxidative stress
0.0603.39E-6SGTC_1747st037496 66.6 μMTimTec (Natural product derivative library)7233050.0185185
0.0603.83E-6SGTC_1459k035-0031 35.7 μMChemDiv (Drug-like library)38771280.0425532DNA intercalators
0.0571.09E-5SGTC_1250133-0007 11.8 μMChemDiv (Drug-like library)265410.025641DNA intercalators
0.0571.12E-5SGTC_2712st079126 47.7 μMTimTec (Natural product derivative library)31529700.0571429
0.0542.87E-5SGTC_2549cedrol 20.9 μMMicrosource (Natural product library)67086650.0869565
0.0543.70E-5SGTC_1465k213-0056 144.0 μMChemDiv (Drug-like library)240488570.046875DNA intercalators
0.0534.11E-5SGTC_1350933-0004 26.3 μMChemDiv (Drug-like library)212306170.016393460S ribosome export
0.0526.04E-5SGTC_29839022671 13.0 μMChembridge (Drug-like library)64051610.01298760S ribosome export
0.0526.29E-5SGTC_2657nystatin 74.4 μMMiscellaneous114687070.0752688

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_180111-0177500 nM0.466667721752ChemDiv (Drug-like library)336.062844.06901
SGTC_20555235184200 μM0.2894742836034Chembridge (Fragment library)283.836743.312ERG2
SGTC_6820kpi-009917 μM0.2820511714895ChemDiv (Drug-like library)235.345182.86503
SGTC_8520418-0143439 μM0.2755369229ChemDiv (Drug-like library)251.390942.66122calcium & mitochondrial duress
SGTC_1080509-0257621.13 μM0.261905536624ChemDiv (Drug-like library)269.381323.3611
SGTC_20144013930200 μM0.25806564556Chembridge (Fragment library)166.260022.11611
SGTC_7420kpi-0133140 μM0.2553192728852ChemDiv (Drug-like library)297.434483.98912ERG2
SGTC_5850kpi-0023191 μM0.2564601ChemDiv (Drug-like library)272.33893.62723
SGTC_8110416-0114265 μM0.239136612453ChemDiv (Drug-like library)281.390482.90113
SGTC_13081187-161741.4 μM0.222882570ChemDiv (Drug-like library)315.449763.31523fatty acid desaturase (OLE1)