Deletion Strain | FD score | P-value | Gene | Gene Description |
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YHR073W | 12.60 | 1.39E-36 | OSH3 | Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability |
YPL069C | 11.40 | 2.99E-30 | BTS1 | Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic |
YNL231C | 10.90 | 5.92E-28 | PDR16 | Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress |
YPL170W | 8.76 | 9.63E-19 | DAP1 | Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis |
YGL186C | 7.15 | 4.34E-13 | TPN1 | Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p |
YER119C-A_d | 6.89 | 2.72E-12 | YER119C-A_d | Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2 |
YLR111W_d | 6.73 | 8.21E-12 | YLR111W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YMR209C_p | 6.38 | 8.63E-11 | YMR209C_p | Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene |
YDL170W | 6.25 | 2.04E-10 | UGA3 | Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus |
YBR058C-A | 5.85 | 2.49E-9 | TSC3 | Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis |
YLR110C | 5.76 | 4.25E-9 | CCW12 | Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication |
YOR067C | 5.74 | 4.62E-9 | ALG8 | Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p |
YBR035C | 5.62 | 9.51E-9 | PDX3 | Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism |
YGL013C | 5.37 | 3.91E-8 | PDR1 | Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication |
YMR115W | 5.00 | 2.85E-7 | MGR3 | Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA |