| Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
|---|
| YJL008C | 6.04 | 7.58E-10 | 1.35 | CCT8 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
| YHR074W | 4.69 | 1.34E-6 | 0.37 | QNS1 | Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide |
| YBR109C | 4.32 | 7.73E-6 | 0.29 | CMD1 | Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin |
| YDL152W_d | 4.03 | 2.74E-5 | 0.06 | YDL152W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome |
| YOR160W | 3.97 | 3.58E-5 | 0.12 | MTR10 | Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress |
| YNL131W | 3.85 | 5.82E-5 | 0.13 | TOM22 | Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes |
| YNL132W | 3.72 | 9.89E-5 | 0.26 | KRE33 | Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance |
| YEL034W | 3.46 | 2.66E-4 | 2.69E-4 | HYP2 | Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication |
| YHR062C | 3.46 | 2.66E-4 | 0.12 | RPP1 | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs |
| YIL142W | 3.34 | 4.20E-4 | 0.05 | CCT2 | Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
| YPR133C | 3.29 | 4.99E-4 | 0.05 | SPN1 | Protein involved in RNA polymerase II transcription; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype |
| YMR203W | 3.24 | 6.02E-4 | 0.04 | TOM40 | Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore |
| YDR449C | 3.20 | 6.87E-4 | 0.09 | UTP6 | Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA |
| YKR083C | 3.11 | 9.31E-4 | 0.00 | DAD2 | Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis |
| YLR075W | 3.11 | 9.42E-4 | 0.00 | RPL10 | Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects |
