| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YMR188C | 7.88 | 1.66E-15 | MRPS17 | Mitochondrial ribosomal protein of the small subunit |
| YMR202W | 7.23 | 2.46E-13 | ERG2 | C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis |
| YNR018W | 5.54 | 1.48E-8 | RCF2 | Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast |
| YOR385W_p | 5.53 | 1.63E-8 | YOR385W_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene |
| YGR180C | 5.13 | 1.49E-7 | RNR4 | Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress |
| YDR071C | 4.72 | 1.20E-6 | PAA1 | Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication |
| YCL040W | 4.70 | 1.32E-6 | GLK1 | Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication |
| YAL020C | 4.60 | 2.16E-6 | ATS1 | Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle |
| YLR149C_p | 4.59 | 2.23E-6 | YLR149C_p | Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress |
| YMR116C | 4.39 | 5.60E-6 | ASC1 | G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation |
| YPL259C | 4.03 | 2.84E-5 | APM1 | Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting |
| YOL076W | 4.01 | 3.04E-5 | MDM20 | Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly |
| YML016C | 3.87 | 5.41E-5 | PPZ1 | Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance |
| YPL086C | 3.85 | 6.00E-5 | ELP3 | Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin |
| YKR073C_d | 3.83 | 6.46E-5 | YKR073C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
