tnp00067

3-hydroxy-2-(3-hydroxyphenyl)chromen-4-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1109
Screen concentration 928.3 nM
Source TimTec (Natural product library)
PubChem CID 676295
SMILES C1=CC=C2C(=C1)C(=O)C(=C(O2)C3=CC(=CC=C3)O)O
Standardized SMILES OC1=C(Oc2ccccc2C1=O)c3cccc(O)c3
Molecular weight 254.2375
ALogP 2.36
H-bond donor count 2
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.72
% growth inhibition (Hom. pool) 4.89


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 676295
Download HIP data (tab-delimited text)  (excel)
Gene:ARC35(YNR035C)|FD-Score:-3.43|P-value:3.07E-4|Clearance:0||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin Gene:ARC40(YBR234C)|FD-Score:-3.23|P-value:6.12E-4|Clearance:0||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Gene:HYP2(YEL034W)|FD-Score:-4.22|P-value:1.20E-5|Clearance:0||SGD DESC:Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication Gene:LTO1(YNL260C_p)|FD-Score:-3.58|P-value:1.72E-4|Clearance:0||SGD DESC:Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species Gene:MCD1(YDL003W)|FD-Score:4.55|P-value:2.72E-6|Clearance:1.23||SGD DESC:Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase Gene:MCD4(YKL165C)|FD-Score:5.83|P-value:2.79E-9|Clearance:1.28||SGD DESC:Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes Gene:MGE1(YOR232W)|FD-Score:3.32|P-value:4.54E-4|Clearance:0.13||SGD DESC:Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE Gene:PRP24(YMR268C)|FD-Score:3.19|P-value:7.17E-4|Clearance:0.23||SGD DESC:Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling Gene:YJU2(YKL095W)|FD-Score:-3.43|P-value:3.07E-4|Clearance:0||SGD DESC:Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC (nineteen complex) and acts after Prp2p to promote the first catalytic reaction of splicing Gene:ARC35(YNR035C)|FD-Score:-3.43|P-value:3.07E-4|Clearance:0||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin Gene:ARC40(YBR234C)|FD-Score:-3.23|P-value:6.12E-4|Clearance:0||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Gene:HYP2(YEL034W)|FD-Score:-4.22|P-value:1.20E-5|Clearance:0||SGD DESC:Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication Gene:LTO1(YNL260C_p)|FD-Score:-3.58|P-value:1.72E-4|Clearance:0||SGD DESC:Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species Gene:MCD1(YDL003W)|FD-Score:4.55|P-value:2.72E-6|Clearance:1.23||SGD DESC:Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase Gene:MCD4(YKL165C)|FD-Score:5.83|P-value:2.79E-9|Clearance:1.28||SGD DESC:Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes Gene:MGE1(YOR232W)|FD-Score:3.32|P-value:4.54E-4|Clearance:0.13||SGD DESC:Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE Gene:PRP24(YMR268C)|FD-Score:3.19|P-value:7.17E-4|Clearance:0.23||SGD DESC:Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling Gene:YJU2(YKL095W)|FD-Score:-3.43|P-value:3.07E-4|Clearance:0||SGD DESC:Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC (nineteen complex) and acts after Prp2p to promote the first catalytic reaction of splicing

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 676295
Download HOP data (tab-delimited text)  (excel)
Gene:AFT1(YGL071W)|FD-Score:3.37|P-value:3.76E-4||SGD DESC:Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:AST2(YER101C)|FD-Score:3.31|P-value:4.67E-4||SGD DESC:Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication Gene:BEM3(YPL115C)|FD-Score:4.84|P-value:6.58E-7||SGD DESC:Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly Gene:BXI1(YNL305C)|FD-Score:-6.01|P-value:9.35E-10||SGD DESC:Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p Gene:COS12(YGL263W)|FD-Score:-3.15|P-value:8.29E-4||SGD DESC:Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins Gene:ERV41(YML067C)|FD-Score:3.48|P-value:2.49E-4||SGD DESC:Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein Gene:FCY1(YPR062W)|FD-Score:5.78|P-value:3.78E-9||SGD DESC:Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) Gene:FRE6(YLL051C)|FD-Score:-3.51|P-value:2.20E-4||SGD DESC:Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels Gene:GMC2(YLR445W)|FD-Score:3.59|P-value:1.66E-4||SGD DESC:Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor Gene:GUP1(YGL084C)|FD-Score:3.7|P-value:1.06E-4||SGD DESC:Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport Gene:GYP1(YOR070C)|FD-Score:-3.29|P-value:5.06E-4||SGD DESC:Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion Gene:HOM2(YDR158W)|FD-Score:4.29|P-value:8.74E-6||SGD DESC:Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis Gene:HOS1(YPR068C)|FD-Score:3.24|P-value:5.94E-4||SGD DESC:Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex Gene:IME2(YJL106W)|FD-Score:3.22|P-value:6.38E-4||SGD DESC:Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p Gene:KEL1(YHR158C)|FD-Score:5.67|P-value:7.33E-9||SGD DESC:Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate Gene:LSM1(YJL124C)|FD-Score:3.99|P-value:3.33E-5||SGD DESC:Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress Gene:MAC1(YMR021C)|FD-Score:4.22|P-value:1.21E-5||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MBF1(YOR298C-A)|FD-Score:-3.68|P-value:1.17E-4||SGD DESC:Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress Gene:MGT1(YDL200C)|FD-Score:3.23|P-value:6.14E-4||SGD DESC:DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage Gene:MSC7(YHR039C)|FD-Score:3.31|P-value:4.62E-4||SGD DESC:Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids Gene:MSO1(YNR049C)|FD-Score:3.13|P-value:8.76E-4||SGD DESC:Probable component of the secretory vesicle docking complex; acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; relocalizes from bud neck to nucleus upon DNA replication stress Gene:NHP6A(YPR052C)|FD-Score:3.58|P-value:1.69E-4||SGD DESC:High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:NMA111(YNL123W)|FD-Score:4.92|P-value:4.40E-7||SGD DESC:Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases Gene:NUP2(YLR335W)|FD-Score:-3.39|P-value:3.50E-4||SGD DESC:Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization Gene:PAA1(YDR071C)|FD-Score:-4.6|P-value:2.10E-6||SGD DESC:Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication Gene:PKH3(YDR466W)|FD-Score:4.15|P-value:1.70E-5||SGD DESC:Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant Gene:PPT2(YPL148C)|FD-Score:5.11|P-value:1.61E-7||SGD DESC:Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation Gene:PUF2(YPR042C)|FD-Score:-4.4|P-value:5.32E-6||SGD DESC:Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins Gene:RAD33(YML011C)|FD-Score:-3.66|P-value:1.27E-4||SGD DESC:Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus Gene:RAI1(YGL246C)|FD-Score:-4.28|P-value:9.50E-6||SGD DESC:Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z Gene:RBK1(YCR036W)|FD-Score:4.8|P-value:7.85E-7||SGD DESC:Putative ribokinase Gene:RDS1(YCR106W)|FD-Score:3.43|P-value:2.98E-4||SGD DESC:Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide Gene:RML2(YEL050C)|FD-Score:3.38|P-value:3.58E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor Gene:RPS26B(YER131W)|FD-Score:3.6|P-value:1.61E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication Gene:RRM3(YHR031C)|FD-Score:3.21|P-value:6.69E-4||SGD DESC:DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p Gene:RTT101(YJL047C)|FD-Score:3.51|P-value:2.22E-4||SGD DESC:Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p Gene:SAK1(YER129W)|FD-Score:4.18|P-value:1.43E-5||SGD DESC:Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome Gene:SOD2(YHR008C)|FD-Score:3.8|P-value:7.26E-5||SGD DESC:Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated Gene:SOV1(YMR066W)|FD-Score:3.18|P-value:7.32E-4||SGD DESC:Mitochondrial protein of unknown function Gene:SPE3(YPR069C)|FD-Score:3.6|P-value:1.60E-4||SGD DESC:Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells Gene:SPG1(YGR236C)|FD-Score:4.13|P-value:1.83E-5||SGD DESC:Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:STE50(YCL032W)|FD-Score:4.17|P-value:1.54E-5||SGD DESC:Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction Gene:TFS1(YLR178C)|FD-Score:-3.27|P-value:5.36E-4||SGD DESC:Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress Gene:UBS1(YBR165W)|FD-Score:-3.78|P-value:7.70E-5||SGD DESC:Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity Gene:VHS3(YOR054C)|FD-Score:3.46|P-value:2.68E-4||SGD DESC:Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis Gene:XRS2(YDR369C)|FD-Score:3.95|P-value:3.88E-5||SGD DESC:Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling Gene:YBL059W(YBL059W_p)|FD-Score:4.04|P-value:2.65E-5||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication Gene:YBR226C(YBR226C_d)|FD-Score:-3.39|P-value:3.47E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W Gene:YBR300C(YBR300C_d)|FD-Score:4.23|P-value:1.16E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene Gene:YBT1(YLL048C)|FD-Score:-3.41|P-value:3.22E-4||SGD DESC:Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters Gene:YDR455C(YDR455C_d)|FD-Score:3.57|P-value:1.78E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W Gene:YER175W-A(YER175W-A_p)|FD-Score:-3.39|P-value:3.45E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YFL041W-A(YFL041W-A_p)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YGR204C-A(YGR204C-A_p)|FD-Score:-3.63|P-value:1.42E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YLL006W-A(YLL006W-A_p)|FD-Score:-3.26|P-value:5.49E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YLR036C(YLR036C_p)|FD-Score:3.27|P-value:5.38E-4||SGD DESC:Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein Gene:YLR278C(YLR278C_p)|FD-Score:4.31|P-value:8.08E-6||SGD DESC:Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene Gene:YOL035C(YOL035C_d)|FD-Score:-3.69|P-value:1.14E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR283W(YOR283W)|FD-Score:3.46|P-value:2.75E-4||SGD DESC:Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene Gene:YPS1(YLR120C)|FD-Score:3.52|P-value:2.18E-4||SGD DESC:Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor Gene:AFT1(YGL071W)|FD-Score:3.37|P-value:3.76E-4||SGD DESC:Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:AST2(YER101C)|FD-Score:3.31|P-value:4.67E-4||SGD DESC:Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication Gene:BEM3(YPL115C)|FD-Score:4.84|P-value:6.58E-7||SGD DESC:Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly Gene:BXI1(YNL305C)|FD-Score:-6.01|P-value:9.35E-10||SGD DESC:Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p Gene:COS12(YGL263W)|FD-Score:-3.15|P-value:8.29E-4||SGD DESC:Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins Gene:ERV41(YML067C)|FD-Score:3.48|P-value:2.49E-4||SGD DESC:Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein Gene:FCY1(YPR062W)|FD-Score:5.78|P-value:3.78E-9||SGD DESC:Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) Gene:FRE6(YLL051C)|FD-Score:-3.51|P-value:2.20E-4||SGD DESC:Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels Gene:GMC2(YLR445W)|FD-Score:3.59|P-value:1.66E-4||SGD DESC:Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor Gene:GUP1(YGL084C)|FD-Score:3.7|P-value:1.06E-4||SGD DESC:Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport Gene:GYP1(YOR070C)|FD-Score:-3.29|P-value:5.06E-4||SGD DESC:Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion Gene:HOM2(YDR158W)|FD-Score:4.29|P-value:8.74E-6||SGD DESC:Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis Gene:HOS1(YPR068C)|FD-Score:3.24|P-value:5.94E-4||SGD DESC:Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex Gene:IME2(YJL106W)|FD-Score:3.22|P-value:6.38E-4||SGD DESC:Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p Gene:KEL1(YHR158C)|FD-Score:5.67|P-value:7.33E-9||SGD DESC:Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate Gene:LSM1(YJL124C)|FD-Score:3.99|P-value:3.33E-5||SGD DESC:Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress Gene:MAC1(YMR021C)|FD-Score:4.22|P-value:1.21E-5||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MBF1(YOR298C-A)|FD-Score:-3.68|P-value:1.17E-4||SGD DESC:Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress Gene:MGT1(YDL200C)|FD-Score:3.23|P-value:6.14E-4||SGD DESC:DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage Gene:MSC7(YHR039C)|FD-Score:3.31|P-value:4.62E-4||SGD DESC:Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids Gene:MSO1(YNR049C)|FD-Score:3.13|P-value:8.76E-4||SGD DESC:Probable component of the secretory vesicle docking complex; acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; relocalizes from bud neck to nucleus upon DNA replication stress Gene:NHP6A(YPR052C)|FD-Score:3.58|P-value:1.69E-4||SGD DESC:High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:NMA111(YNL123W)|FD-Score:4.92|P-value:4.40E-7||SGD DESC:Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases Gene:NUP2(YLR335W)|FD-Score:-3.39|P-value:3.50E-4||SGD DESC:Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization Gene:PAA1(YDR071C)|FD-Score:-4.6|P-value:2.10E-6||SGD DESC:Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication Gene:PKH3(YDR466W)|FD-Score:4.15|P-value:1.70E-5||SGD DESC:Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant Gene:PPT2(YPL148C)|FD-Score:5.11|P-value:1.61E-7||SGD DESC:Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation Gene:PUF2(YPR042C)|FD-Score:-4.4|P-value:5.32E-6||SGD DESC:Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins Gene:RAD33(YML011C)|FD-Score:-3.66|P-value:1.27E-4||SGD DESC:Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus Gene:RAI1(YGL246C)|FD-Score:-4.28|P-value:9.50E-6||SGD DESC:Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z Gene:RBK1(YCR036W)|FD-Score:4.8|P-value:7.85E-7||SGD DESC:Putative ribokinase Gene:RDS1(YCR106W)|FD-Score:3.43|P-value:2.98E-4||SGD DESC:Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide Gene:RML2(YEL050C)|FD-Score:3.38|P-value:3.58E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor Gene:RPS26B(YER131W)|FD-Score:3.6|P-value:1.61E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication Gene:RRM3(YHR031C)|FD-Score:3.21|P-value:6.69E-4||SGD DESC:DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p Gene:RTT101(YJL047C)|FD-Score:3.51|P-value:2.22E-4||SGD DESC:Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p Gene:SAK1(YER129W)|FD-Score:4.18|P-value:1.43E-5||SGD DESC:Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome Gene:SOD2(YHR008C)|FD-Score:3.8|P-value:7.26E-5||SGD DESC:Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated Gene:SOV1(YMR066W)|FD-Score:3.18|P-value:7.32E-4||SGD DESC:Mitochondrial protein of unknown function Gene:SPE3(YPR069C)|FD-Score:3.6|P-value:1.60E-4||SGD DESC:Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells Gene:SPG1(YGR236C)|FD-Score:4.13|P-value:1.83E-5||SGD DESC:Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:STE50(YCL032W)|FD-Score:4.17|P-value:1.54E-5||SGD DESC:Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction Gene:TFS1(YLR178C)|FD-Score:-3.27|P-value:5.36E-4||SGD DESC:Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress Gene:UBS1(YBR165W)|FD-Score:-3.78|P-value:7.70E-5||SGD DESC:Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity Gene:VHS3(YOR054C)|FD-Score:3.46|P-value:2.68E-4||SGD DESC:Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis Gene:XRS2(YDR369C)|FD-Score:3.95|P-value:3.88E-5||SGD DESC:Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling Gene:YBL059W(YBL059W_p)|FD-Score:4.04|P-value:2.65E-5||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication Gene:YBR226C(YBR226C_d)|FD-Score:-3.39|P-value:3.47E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W Gene:YBR300C(YBR300C_d)|FD-Score:4.23|P-value:1.16E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene Gene:YBT1(YLL048C)|FD-Score:-3.41|P-value:3.22E-4||SGD DESC:Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters Gene:YDR455C(YDR455C_d)|FD-Score:3.57|P-value:1.78E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W Gene:YER175W-A(YER175W-A_p)|FD-Score:-3.39|P-value:3.45E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YFL041W-A(YFL041W-A_p)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YGR204C-A(YGR204C-A_p)|FD-Score:-3.63|P-value:1.42E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YLL006W-A(YLL006W-A_p)|FD-Score:-3.26|P-value:5.49E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YLR036C(YLR036C_p)|FD-Score:3.27|P-value:5.38E-4||SGD DESC:Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein Gene:YLR278C(YLR278C_p)|FD-Score:4.31|P-value:8.08E-6||SGD DESC:Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene Gene:YOL035C(YOL035C_d)|FD-Score:-3.69|P-value:1.14E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR283W(YOR283W)|FD-Score:3.46|P-value:2.75E-4||SGD DESC:Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene Gene:YPS1(YLR120C)|FD-Score:3.52|P-value:2.18E-4||SGD DESC:Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YKL165C5.832.79E-91.28MCD4Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
YDL003W4.552.72E-61.23MCD1Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase
YOR232W3.324.54E-40.13MGE1Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE
YMR268C3.197.17E-40.23PRP24Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling
YPR182W2.960.001540.00SMX3Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F
YBL105C2.960.001550.08PKC1Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
YLR458W_d2.880.002020.07YLR458W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis
YDL111C2.810.002480.02RRP42Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
YPL063W2.790.002660.03TIM50Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel
YDR013W2.760.002930.07PSF1Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
YNL178W2.680.003660.06RPS3Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
YGL055W2.620.004390.03OLE1Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YOR074C2.590.004790.05CDC21Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
YKL019W2.540.005470.07RAM2Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
YJR076C2.470.006760.07CDC11Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YPR062W5.783.78E-9FCY1Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)
YHR158C5.677.33E-9KEL1Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate
YPL148C5.111.61E-7PPT2Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation
YNL123W4.924.40E-7NMA111Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
YPL115C4.846.58E-7BEM3Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
YCR036W4.807.85E-7RBK1Putative ribokinase
YLR278C_p4.318.08E-6YLR278C_pZinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene
YDR158W4.298.74E-6HOM2Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
YBR300C_d4.231.16E-5YBR300C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene
YMR021C4.221.21E-5MAC1Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
YER129W4.181.43E-5SAK1Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YCL032W4.171.54E-5STE50Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction
YDR466W4.151.70E-5PKH3Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
YGR236C4.131.83E-5SPG1Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBL059W_p4.042.65E-5YBL059W_pPutative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication

GO enrichment analysis for SGTC_1109
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1023.95E-15SGTC_1108betulinic acid 729.1 nMTimTec (Natural product library)649450.0487805
0.1001.50E-14SGTC_1111tnp00062 510.7 nMTimTec (Natural product library)6763060.272727
0.0912.51E-12SGTC_22226885208 172.1 μMChembridge (Fragment library)6095140.142857
0.0707.28E-8SGTC_1078idebenone 36.1 μMMiscellaneous36860.0877193Golgi
0.0707.30E-8SGTC_30519093778 49.5 μMChembridge (Drug-like library)172173780.115942
0.0699.82E-8SGTC_1533dihydroergotamine mesylate 29.4 μMTimTec (Pure natural product library)711710.0925926DNA intercalators
0.0681.76E-7SGTC_14790549-0158 134.0 μMChemDiv (Drug-like library)54402020.22807
0.0649.22E-7SGTC_1660st012960 28.1 μMTimTec (Natural product derivative library)242072660.0869565iron homeostasis
0.0631.43E-6SGTC_1569carminic acid 40.6 μMTimTec (Pure natural product library)147490.133333
0.0631.51E-6SGTC_1645Cervolide 78.0 μMTimTec (Natural product derivative library)231730.0816327
0.0621.68E-6SGTC_20685226020 147.0 μMChembridge (Fragment library)18105090.113208
0.0621.98E-6SGTC_1000086-0128 49.6 μMChemDiv (Drug-like library)932970.116667copper-dependent oxidative stress
0.0613.25E-6SGTC_29237992654 58.1 μMChembridge (Drug-like library)29851260.0923077Golgi
0.0588.91E-6SGTC_1390099-0334 718.6 μMChemDiv (Drug-like library)976900.118644
0.0571.18E-5SGTC_13923455-1037 33.9 μMChemDiv (Drug-like library)9811320.169014

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_15823',3',6'-trihydroxyflavone74 μM0.783784688803TimTec (Pure natural product library)270.23692.11435
SGTC_1112tnp000691.17 μM0.692308145826TimTec (Natural product library)270.23692.11435
SGTC_11103-hydroxy-3'-methoxyflavone1.24 μM0.690476676296TimTec (Natural product library)268.264082.58214iron homeostasis
SGTC_1830st05598250.3 μM0.605263455313TimTec (Natural product derivative library)254.23752.35624
SGTC_15494'-methoxyflavonol74.6 μM0.58139597141TimTec (Pure natural product library)268.264082.58214
SGTC_1124fisetin1.16 μM0.558145281614TimTec (Natural product library)286.23631.87246
SGTC_1115galangin695.68 nM0.55281616TimTec (Natural product library)270.23692.11435RPP1 & pyrimidine depletion
SGTC_2505galangin7.89 μM0.55281616Microsource (Natural product library)270.23692.11435RPP1 & pyrimidine depletion
SGTC_1868st05764442.7 μM0.489362688665TimTec (Natural product derivative library)282.290662.80804
SGTC_18943',6'-dihydroxyflavone78.7 μM0.466667688662TimTec (Natural product derivative library)254.23752.65224
SGTC_1766st04541444.77 μM0.46253960TimTec (Natural product derivative library)273.671222.11214RPP1 & pyrimidine depletion