0083-0039

6-ethoxy-3-methylphenalen-1-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_111
Screen concentration 52.5 μM
Source ChemDiv (Drug-like library)
PubChem CID 759313
SMILES CCOC1=C2C=CC=C3C2=C(C=C1)C(=CC3=O)C
Standardized SMILES CCOc1ccc2C(=CC(=O)c3cccc1c23)C
Molecular weight 238.2812
ALogP 3.56
H-bond donor count 0
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 12.69
% growth inhibition (Hom. pool) 12.06


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 759313
Download HIP data (tab-delimited text)  (excel)
Gene:NMD3(YHR170W)|FD-Score:-4.03|P-value:2.77E-5|Clearance:0||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:NSL1(YPL233W)|FD-Score:5.03|P-value:2.46E-7|Clearance:1.88||SGD DESC:Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation Gene:RPB10(YOR210W)|FD-Score:3.14|P-value:8.31E-4|Clearance:0.15||SGD DESC:RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III Gene:RPC11(YDR045C)|FD-Score:-4.24|P-value:1.10E-5|Clearance:0||SGD DESC:RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS Gene:NMD3(YHR170W)|FD-Score:-4.03|P-value:2.77E-5|Clearance:0||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:NSL1(YPL233W)|FD-Score:5.03|P-value:2.46E-7|Clearance:1.88||SGD DESC:Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation Gene:RPB10(YOR210W)|FD-Score:3.14|P-value:8.31E-4|Clearance:0.15||SGD DESC:RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III Gene:RPC11(YDR045C)|FD-Score:-4.24|P-value:1.10E-5|Clearance:0||SGD DESC:RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 759313
Download HOP data (tab-delimited text)  (excel)
Gene:ARF3(YOR094W)|FD-Score:3.3|P-value:4.77E-4||SGD DESC:Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity Gene:BTS1(YPL069C)|FD-Score:3.47|P-value:2.60E-4||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:CAX4(YGR036C)|FD-Score:-3.27|P-value:5.44E-4||SGD DESC:Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation Gene:CIN1(YOR349W)|FD-Score:3.58|P-value:1.69E-4||SGD DESC:Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl Gene:DOG1(YHR044C)|FD-Score:3.4|P-value:3.35E-4||SGD DESC:2-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified Gene:DUS3(YLR401C)|FD-Score:3.47|P-value:2.63E-4||SGD DESC:Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress Gene:FRE5(YOR384W)|FD-Score:-3.54|P-value:2.01E-4||SGD DESC:Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:FUI1(YBL042C)|FD-Score:-3.61|P-value:1.51E-4||SGD DESC:High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress Gene:FYV6(YNL133C)|FD-Score:-3.81|P-value:6.85E-5||SGD DESC:Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining Gene:HUL4(YJR036C)|FD-Score:-3.14|P-value:8.36E-4||SGD DESC:Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex Gene:IRC2(YDR112W_d)|FD-Score:3.62|P-value:1.45E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci Gene:JIP3(YLR331C_d)|FD-Score:4.17|P-value:1.50E-5||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2 Gene:LSB5(YCL034W)|FD-Score:-3.1|P-value:9.61E-4||SGD DESC:Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat Gene:MID1(YNL291C)|FD-Score:6.62|P-value:1.77E-11||SGD DESC:N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer Gene:MOT2(YER068W)|FD-Score:-3.25|P-value:5.87E-4||SGD DESC:Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications Gene:OCH1(YGL038C)|FD-Score:-3.35|P-value:4.08E-4||SGD DESC:Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins Gene:PUS5(YLR165C)|FD-Score:-3.18|P-value:7.46E-4||SGD DESC:Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability Gene:RAD14(YMR201C)|FD-Score:4.03|P-value:2.80E-5||SGD DESC:Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein Gene:RPL31A(YDL075W)|FD-Score:-3.35|P-value:4.04E-4||SGD DESC:Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication Gene:SAM37(YMR060C)|FD-Score:-3.33|P-value:4.34E-4||SGD DESC:Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability Gene:SUC2(YIL162W)|FD-Score:3.18|P-value:7.33E-4||SGD DESC:Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively Gene:TCB1(YOR086C)|FD-Score:3.32|P-value:4.56E-4||SGD DESC:Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact Gene:THI20(YOL055C)|FD-Score:3.76|P-value:8.60E-5||SGD DESC:Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p Gene:VMA5(YKL080W)|FD-Score:-3.79|P-value:7.67E-5||SGD DESC:Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane Gene:VPS34(YLR240W)|FD-Score:-4.34|P-value:7.05E-6||SGD DESC:Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery Gene:YDL109C(YDL109C_p)|FD-Score:-4.03|P-value:2.80E-5||SGD DESC:Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication Gene:YER135C(YER135C_d)|FD-Score:-4.46|P-value:4.01E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene Gene:YIR044C(YIR044C)|FD-Score:-3.11|P-value:9.40E-4||SGD DESC:Possible pseudogene in strain S288C; YIR044C and the adjacent ORF, YIR043C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family Gene:ARF3(YOR094W)|FD-Score:3.3|P-value:4.77E-4||SGD DESC:Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity Gene:BTS1(YPL069C)|FD-Score:3.47|P-value:2.60E-4||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:CAX4(YGR036C)|FD-Score:-3.27|P-value:5.44E-4||SGD DESC:Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation Gene:CIN1(YOR349W)|FD-Score:3.58|P-value:1.69E-4||SGD DESC:Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl Gene:DOG1(YHR044C)|FD-Score:3.4|P-value:3.35E-4||SGD DESC:2-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified Gene:DUS3(YLR401C)|FD-Score:3.47|P-value:2.63E-4||SGD DESC:Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress Gene:FRE5(YOR384W)|FD-Score:-3.54|P-value:2.01E-4||SGD DESC:Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:FUI1(YBL042C)|FD-Score:-3.61|P-value:1.51E-4||SGD DESC:High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress Gene:FYV6(YNL133C)|FD-Score:-3.81|P-value:6.85E-5||SGD DESC:Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining Gene:HUL4(YJR036C)|FD-Score:-3.14|P-value:8.36E-4||SGD DESC:Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex Gene:IRC2(YDR112W_d)|FD-Score:3.62|P-value:1.45E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci Gene:JIP3(YLR331C_d)|FD-Score:4.17|P-value:1.50E-5||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2 Gene:LSB5(YCL034W)|FD-Score:-3.1|P-value:9.61E-4||SGD DESC:Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat Gene:MID1(YNL291C)|FD-Score:6.62|P-value:1.77E-11||SGD DESC:N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer Gene:MOT2(YER068W)|FD-Score:-3.25|P-value:5.87E-4||SGD DESC:Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications Gene:OCH1(YGL038C)|FD-Score:-3.35|P-value:4.08E-4||SGD DESC:Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins Gene:PUS5(YLR165C)|FD-Score:-3.18|P-value:7.46E-4||SGD DESC:Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability Gene:RAD14(YMR201C)|FD-Score:4.03|P-value:2.80E-5||SGD DESC:Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein Gene:RPL31A(YDL075W)|FD-Score:-3.35|P-value:4.04E-4||SGD DESC:Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication Gene:SAM37(YMR060C)|FD-Score:-3.33|P-value:4.34E-4||SGD DESC:Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability Gene:SUC2(YIL162W)|FD-Score:3.18|P-value:7.33E-4||SGD DESC:Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively Gene:TCB1(YOR086C)|FD-Score:3.32|P-value:4.56E-4||SGD DESC:Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact Gene:THI20(YOL055C)|FD-Score:3.76|P-value:8.60E-5||SGD DESC:Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p Gene:VMA5(YKL080W)|FD-Score:-3.79|P-value:7.67E-5||SGD DESC:Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane Gene:VPS34(YLR240W)|FD-Score:-4.34|P-value:7.05E-6||SGD DESC:Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery Gene:YDL109C(YDL109C_p)|FD-Score:-4.03|P-value:2.80E-5||SGD DESC:Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication Gene:YER135C(YER135C_d)|FD-Score:-4.46|P-value:4.01E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene Gene:YIR044C(YIR044C)|FD-Score:-3.11|P-value:9.40E-4||SGD DESC:Possible pseudogene in strain S288C; YIR044C and the adjacent ORF, YIR043C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YPL233W5.032.46E-71.88NSL1Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
YOR210W3.148.31E-40.15RPB10RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III
YKL060C3.000.001360.29FBA1Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress
YBR049C2.710.003370.01REB1RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; REB1 has a paralog, NSI1, that arose from the whole genome duplication
YOL069W2.700.003420.13NUF2Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
YPR181C2.580.004980.04SEC23GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p
YDR526C_d2.540.005530.00YDR526C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL255W2.540.005560.04BBP1Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p
YGL171W2.500.006230.00ROK1RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation
YNL251C2.500.006290.01NRD1RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), preferentially at phosphorylated Ser5, to direct transcription termination of non-polyadenylated transcripts; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites
YDL120W2.480.006550.11YFH1Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia
YKL141W2.370.008970.07SDH3Subunit of both succinate dehydrogenase and of TIM22 translocase; functions as the cytochrome b subunit of succinate dehydrogenase, which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex
YBR256C2.290.010900.02RIB5Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
YLR397C2.270.011700.07AFG2ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; releases Rlp24p from purified pre-60S particles in vitro; may be involved in degradation of aberrant mRNAs
YKR004C2.200.013800.05ECM9Non-essential protein of unknown function

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YNL291C6.621.77E-11MID1N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
YLR331C_d4.171.50E-5JIP3_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
YMR201C4.032.80E-5RAD14Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
YOL055C3.768.60E-5THI20Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p
YDR112W_d3.621.45E-4IRC2_dDubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci
YOR349W3.581.69E-4CIN1Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
YPL069C3.472.60E-4BTS1Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic
YLR401C3.472.63E-4DUS3Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
YHR044C3.403.35E-4DOG12-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified
YOR086C3.324.56E-4TCB1Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
YOR094W3.304.77E-4ARF3Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity
YIL162W3.187.33E-4SUC2Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YPL019C3.010.00129VTC3Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
YFL047W3.000.00136RGD2GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress
YOR346W2.880.00201REV1Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress

GO enrichment analysis for SGTC_111
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0921.65E-12SGTC_2525harmine 47.9 μMMiscellaneous52809530.114754ergosterol biosynthesis
0.0832.21E-10SGTC_22095-(5-methyl-2-thenylidene)-Barbituric acid 122.8 μMChembridge (Fragment library)6167640.125
0.0822.45E-10SGTC_2674-Nitroquinoline-1-oxide (4-NQO) 44.4 nMMiscellaneous59550.127273DNA damage response
0.0807.28E-10SGTC_1100850-0284 111.6 μMChemDiv (Drug-like library)39062650.0933333
0.0759.40E-9SGTC_23509023895 38.9 μMChembridge (Fragment library)29972090.0793651ergosterol biosynthesis
0.0691.00E-7SGTC_24875918373 44.0 μMMiscellaneous28762790.106667
0.0691.04E-7SGTC_417st075190 100.0 μMTimTec (Pure natural product library)2227570.0864198
0.0612.65E-6SGTC_185k048-0037 25.5 μMChemDiv (Drug-like library)68275890.0704225RSC & ERG11
0.0604.22E-6SGTC_1764st044502 93.5 μMTimTec (Natural product derivative library)84070.0909091
0.0604.72E-6SGTC_29479072639 7.7 μMChembridge (Drug-like library)164881460.105263tubulin folding & SWR complex
0.0595.22E-6SGTC_24835729050 27.2 μMMiscellaneous28651800.183099
0.0588.19E-6SGTC_1717st033143 58.0 μMTimTec (Natural product derivative library)6746160.153846
0.0571.23E-5SGTC_23759072683 200.0 μMChembridge (Fragment library)167980290.125mitochondrial processes
0.0571.34E-5SGTC_10553448-0672 86.0 μMChemDiv (Drug-like library)7483780.112903
0.0561.51E-5SGTC_813k007-0158 173.0 μMChemDiv (Drug-like library)65239160.0769231fatty acid desaturase (OLE1)

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_2681menadione3.18 μM0.3658544055Miscellaneous172.180022.20402superoxide
SGTC_394menadione8.33 μM0.3658544055Miscellaneous172.180022.20402superoxide
SGTC_1904st06022578 μM0.3666595TimTec (Natural product derivative library)204.221882.67803
SGTC_1900st06020072.8 μM0.333333688945TimTec (Natural product derivative library)204.221882.67803
SGTC_22037227154166.4 μM0.333333896304Chembridge (Fragment library)202.249062.46612
SGTC_22137173844200 μM0.321429892728Chembridge (Fragment library)259.300382.62204
SGTC_1556plumbagin1.48 μM0.31914910205TimTec (Pure natural product library)188.179421.96213superoxide
SGTC_2575plumbagin510 nM0.31914910205TimTec (Pure natural product library)188.179421.96213superoxide
SGTC_1902st06021270.5 μM0.307692688944TimTec (Natural product derivative library)204.221882.42203
SGTC_2023594-051334.79 μM0.285714708429ChemDiv (Drug-like library)292.084942.32613PDR1
SGTC_1907st06021083.7 μM0.283019688793TimTec (Natural product derivative library)204.221882.42203
SGTC_290299-000412.98 μM0.28260916871ChemDiv (Drug-like library)188.179421.44503