jasmonic acid

2-[(1R,2R)-3-oxo-2-[(Z)-pent-2-enyl]cyclopentyl]acetic acid

Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 

PubChem MeSH terms: Plant Growth Regulators



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1116
Screen concentration 1.6 μM
Source TimTec (Natural product library)
PubChem CID 5281166
SMILES CCC=CCC1C(CCC1=O)CC(=O)O
Standardized SMILES CCC=CCC1C(CC(=O)O)CCC1=O
Molecular weight 210.2695
ALogP 2.13
H-bond donor count 1
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 2.93
% growth inhibition (Hom. pool) -2.59


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 5281166
Download HIP data (tab-delimited text)  (excel)
Gene:ARC40(YBR234C)|FD-Score:3.17|P-value:7.73E-4|Clearance:0.01||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Gene:CDC28(YBR160W)|FD-Score:3.22|P-value:6.51E-4|Clearance:0.03||SGD DESC:Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates; involved in modulating membrane trafficking dynamics; protein abundance increases in response to DNA replication stress Gene:CDC53(YDL132W)|FD-Score:-3.38|P-value:3.59E-4|Clearance:0||SGD DESC:Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation Gene:DAD2(YKR083C)|FD-Score:3.16|P-value:7.99E-4|Clearance:0.06||SGD DESC:Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis Gene:FCP1(YMR277W)|FD-Score:3.1|P-value:9.69E-4|Clearance:0.02||SGD DESC:Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p) Gene:KRI1(YNL308C)|FD-Score:-3.15|P-value:8.05E-4|Clearance:0||SGD DESC:Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p Gene:MRD1(YPR112C)|FD-Score:3.91|P-value:4.65E-5|Clearance:0.19||SGD DESC:Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region Gene:NOC2(YOR206W)|FD-Score:3.72|P-value:1.00E-4|Clearance:0.37||SGD DESC:Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors Gene:PRP6(YBR055C)|FD-Score:-3.46|P-value:2.72E-4|Clearance:0||SGD DESC:Splicing factor, component of the U4/U6-U5 snRNP complex Gene:RER2(YBR002C)|FD-Score:3.19|P-value:7.16E-4|Clearance:0.02||SGD DESC:Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting Gene:RLP7(YNL002C)|FD-Score:3.34|P-value:4.14E-4|Clearance:0.13||SGD DESC:Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs Gene:RPC53(YDL150W)|FD-Score:-3.32|P-value:4.57E-4|Clearance:0||SGD DESC:RNA polymerase III subunit C53 Gene:SPT15(YER148W)|FD-Score:-3.25|P-value:5.78E-4|Clearance:0||SGD DESC:TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability Gene:SSU72(YNL222W)|FD-Score:-3.64|P-value:1.34E-4|Clearance:0||SGD DESC:Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo Gene:TIM44(YIL022W)|FD-Score:4.53|P-value:2.95E-6|Clearance:0.62||SGD DESC:Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex) Gene:UTP4(YDR324C)|FD-Score:4.97|P-value:3.37E-7|Clearance:0.44||SGD DESC:Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript Gene:UTP8(YGR128C)|FD-Score:6.16|P-value:3.69E-10|Clearance:1.19||SGD DESC:Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA Gene:VAS1(YGR094W)|FD-Score:-3.33|P-value:4.33E-4|Clearance:0||SGD DESC:Mitochondrial and cytoplasmic valyl-tRNA synthetase Gene:YRA1(YDR381W)|FD-Score:-4.24|P-value:1.13E-5|Clearance:0||SGD DESC:RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member Gene:ARC40(YBR234C)|FD-Score:3.17|P-value:7.73E-4|Clearance:0.01||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Gene:CDC28(YBR160W)|FD-Score:3.22|P-value:6.51E-4|Clearance:0.03||SGD DESC:Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates; involved in modulating membrane trafficking dynamics; protein abundance increases in response to DNA replication stress Gene:CDC53(YDL132W)|FD-Score:-3.38|P-value:3.59E-4|Clearance:0||SGD DESC:Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation Gene:DAD2(YKR083C)|FD-Score:3.16|P-value:7.99E-4|Clearance:0.06||SGD DESC:Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis Gene:FCP1(YMR277W)|FD-Score:3.1|P-value:9.69E-4|Clearance:0.02||SGD DESC:Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p) Gene:KRI1(YNL308C)|FD-Score:-3.15|P-value:8.05E-4|Clearance:0||SGD DESC:Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p Gene:MRD1(YPR112C)|FD-Score:3.91|P-value:4.65E-5|Clearance:0.19||SGD DESC:Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region Gene:NOC2(YOR206W)|FD-Score:3.72|P-value:1.00E-4|Clearance:0.37||SGD DESC:Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors Gene:PRP6(YBR055C)|FD-Score:-3.46|P-value:2.72E-4|Clearance:0||SGD DESC:Splicing factor, component of the U4/U6-U5 snRNP complex Gene:RER2(YBR002C)|FD-Score:3.19|P-value:7.16E-4|Clearance:0.02||SGD DESC:Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting Gene:RLP7(YNL002C)|FD-Score:3.34|P-value:4.14E-4|Clearance:0.13||SGD DESC:Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs Gene:RPC53(YDL150W)|FD-Score:-3.32|P-value:4.57E-4|Clearance:0||SGD DESC:RNA polymerase III subunit C53 Gene:SPT15(YER148W)|FD-Score:-3.25|P-value:5.78E-4|Clearance:0||SGD DESC:TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability Gene:SSU72(YNL222W)|FD-Score:-3.64|P-value:1.34E-4|Clearance:0||SGD DESC:Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo Gene:TIM44(YIL022W)|FD-Score:4.53|P-value:2.95E-6|Clearance:0.62||SGD DESC:Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex) Gene:UTP4(YDR324C)|FD-Score:4.97|P-value:3.37E-7|Clearance:0.44||SGD DESC:Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript Gene:UTP8(YGR128C)|FD-Score:6.16|P-value:3.69E-10|Clearance:1.19||SGD DESC:Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA Gene:VAS1(YGR094W)|FD-Score:-3.33|P-value:4.33E-4|Clearance:0||SGD DESC:Mitochondrial and cytoplasmic valyl-tRNA synthetase Gene:YRA1(YDR381W)|FD-Score:-4.24|P-value:1.13E-5|Clearance:0||SGD DESC:RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 5281166
Download HOP data (tab-delimited text)  (excel)
Gene:ABF2(YMR072W)|FD-Score:3.26|P-value:5.66E-4||SGD DESC:Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation Gene:AKR1(YDR264C)|FD-Score:3.54|P-value:1.98E-4||SGD DESC:Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication Gene:ART5(YGR068C)|FD-Score:4.57|P-value:2.46E-6||SGD DESC:Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane Gene:AVT4(YNL101W)|FD-Score:3.45|P-value:2.76E-4||SGD DESC:Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gene:BOI1(YBL085W)|FD-Score:6.35|P-value:1.10E-10||SGD DESC:Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication Gene:CRG1(YHR209W)|FD-Score:-3.87|P-value:5.38E-5||SGD DESC:S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin Gene:CWC21(YDR482C)|FD-Score:3.52|P-value:2.18E-4||SGD DESC:Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p Gene:DIC1(YLR348C)|FD-Score:-3.32|P-value:4.53E-4||SGD DESC:Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix Gene:DOC1(YGL240W)|FD-Score:3.21|P-value:6.74E-4||SGD DESC:Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain Gene:ERG3(YLR056W)|FD-Score:4.25|P-value:1.05E-5||SGD DESC:C-5 sterol desaturase, glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase Gene:FAU1(YER183C)|FD-Score:-3.21|P-value:6.69E-4||SGD DESC:5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis Gene:GIS3(YLR094C)|FD-Score:3.2|P-value:6.88E-4||SGD DESC:Protein of unknown function Gene:GOS1(YHL031C)|FD-Score:4.51|P-value:3.26E-6||SGD DESC:v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28 Gene:GYP8(YFL027C)|FD-Score:3.2|P-value:6.93E-4||SGD DESC:GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport Gene:HOS1(YPR068C)|FD-Score:3.57|P-value:1.77E-4||SGD DESC:Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex Gene:IES4(YOR189W)|FD-Score:3.31|P-value:4.71E-4||SGD DESC:Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses Gene:LAA1(YJL207C)|FD-Score:-3.35|P-value:4.00E-4||SGD DESC:AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene Gene:MCH4(YOL119C)|FD-Score:4.35|P-value:6.81E-6||SGD DESC:Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport Gene:MMR1(YLR190W)|FD-Score:4.9|P-value:4.69E-7||SGD DESC:Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p Gene:MNN5(YJL186W)|FD-Score:4.69|P-value:1.39E-6||SGD DESC:Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment Gene:MRH1(YDR033W)|FD-Score:3.33|P-value:4.29E-4||SGD DESC:Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; MRH1 has a paralog, YRO2, that arose from the whole genome duplication Gene:MRPL10(YNL284C)|FD-Score:3.25|P-value:5.74E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels Gene:MRPS17(YMR188C)|FD-Score:4.15|P-value:1.64E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MTG1(YMR097C)|FD-Score:3.44|P-value:2.92E-4||SGD DESC:Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals Gene:MUK1(YPL070W)|FD-Score:4.16|P-value:1.57E-5||SGD DESC:Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation Gene:NPP2(YEL016C)|FD-Score:-4.08|P-value:2.21E-5||SGD DESC:Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication Gene:PET112(YBL080C)|FD-Score:4.25|P-value:1.09E-5||SGD DESC:Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog Gene:PHR1(YOR386W)|FD-Score:3.46|P-value:2.70E-4||SGD DESC:DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p Gene:PTC1(YDL006W)|FD-Score:5.21|P-value:9.61E-8||SGD DESC:Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation Gene:RAD51(YER095W)|FD-Score:3.41|P-value:3.28E-4||SGD DESC:Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein Gene:RAS2(YNL098C)|FD-Score:3.1|P-value:9.69E-4||SGD DESC:GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes Gene:RBK1(YCR036W)|FD-Score:3.1|P-value:9.58E-4||SGD DESC:Putative ribokinase Gene:RGL1(YPL066W)|FD-Score:4.65|P-value:1.62E-6||SGD DESC:Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source Gene:RPL20A(YMR242C)|FD-Score:4.3|P-value:8.45E-6||SGD DESC:Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication Gene:RPL7B(YPL198W)|FD-Score:3.9|P-value:4.82E-5||SGD DESC:Ribosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication Gene:RTT101(YJL047C)|FD-Score:4.08|P-value:2.25E-5||SGD DESC:Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p Gene:SEC66(YBR171W)|FD-Score:4.27|P-value:9.69E-6||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SFM1(YOR021C)|FD-Score:3.51|P-value:2.21E-4||SGD DESC:SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism Gene:SHE4(YOR035C)|FD-Score:3.13|P-value:8.84E-4||SGD DESC:Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization Gene:SNF2(YOR290C)|FD-Score:3.81|P-value:6.86E-5||SGD DESC:Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p Gene:SOL2(YCR073W-A)|FD-Score:5.64|P-value:8.58E-9||SGD DESC:Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication Gene:SRB8(YCR081W)|FD-Score:7.71|P-value:6.35E-15||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression Gene:TMA19(YKL056C)|FD-Score:3.2|P-value:6.84E-4||SGD DESC:Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress Gene:TOD6(YBL054W)|FD-Score:-3.29|P-value:5.01E-4||SGD DESC:PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; TOD6 has a paralog, DOT6, that arose from the whole genome duplication Gene:TRM12(YML005W)|FD-Score:-3.44|P-value:2.88E-4||SGD DESC:S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA Gene:TRP4(YDR354W)|FD-Score:5.18|P-value:1.09E-7||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:VBA5(YKR105C_p)|FD-Score:-3.39|P-value:3.50E-4||SGD DESC:Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; similar to Vba3p Gene:YDR467C(YDR467C_d)|FD-Score:4.53|P-value:2.90E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YER121W(YER121W_p)|FD-Score:4.32|P-value:7.95E-6||SGD DESC:Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy Gene:YKL115C(YKL115C_d)|FD-Score:4.81|P-value:7.37E-7||SGD DESC:Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1 Gene:YLR030W(YLR030W_p)|FD-Score:-4.31|P-value:8.15E-6||SGD DESC:Putative protein of unknown function Gene:YLR455W(YLR455W_p)|FD-Score:4.1|P-value:2.08E-5||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); protein abundance increases in response to DNA replication stress Gene:YME2(YMR302C)|FD-Score:3.75|P-value:8.84E-5||SGD DESC:Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases Gene:YMR272W-B(YMR272W-B_p)|FD-Score:3.78|P-value:7.83E-5||SGD DESC:Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YNL195C(YNL195C_p)|FD-Score:3.72|P-value:9.89E-5||SGD DESC:Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YOR097C(YOR097C_p)|FD-Score:3.18|P-value:7.34E-4||SGD DESC:Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene Gene:YPR123C(YPR123C_d)|FD-Score:4.05|P-value:2.55E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR Gene:YPT7(YML001W)|FD-Score:3.2|P-value:6.90E-4||SGD DESC:Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7 Gene:ZRG8(YER033C)|FD-Score:3.45|P-value:2.84E-4||SGD DESC:Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency Gene:ABF2(YMR072W)|FD-Score:3.26|P-value:5.66E-4||SGD DESC:Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation Gene:AKR1(YDR264C)|FD-Score:3.54|P-value:1.98E-4||SGD DESC:Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication Gene:ART5(YGR068C)|FD-Score:4.57|P-value:2.46E-6||SGD DESC:Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane Gene:AVT4(YNL101W)|FD-Score:3.45|P-value:2.76E-4||SGD DESC:Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gene:BOI1(YBL085W)|FD-Score:6.35|P-value:1.10E-10||SGD DESC:Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication Gene:CRG1(YHR209W)|FD-Score:-3.87|P-value:5.38E-5||SGD DESC:S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin Gene:CWC21(YDR482C)|FD-Score:3.52|P-value:2.18E-4||SGD DESC:Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p Gene:DIC1(YLR348C)|FD-Score:-3.32|P-value:4.53E-4||SGD DESC:Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix Gene:DOC1(YGL240W)|FD-Score:3.21|P-value:6.74E-4||SGD DESC:Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain Gene:ERG3(YLR056W)|FD-Score:4.25|P-value:1.05E-5||SGD DESC:C-5 sterol desaturase, glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase Gene:FAU1(YER183C)|FD-Score:-3.21|P-value:6.69E-4||SGD DESC:5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis Gene:GIS3(YLR094C)|FD-Score:3.2|P-value:6.88E-4||SGD DESC:Protein of unknown function Gene:GOS1(YHL031C)|FD-Score:4.51|P-value:3.26E-6||SGD DESC:v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28 Gene:GYP8(YFL027C)|FD-Score:3.2|P-value:6.93E-4||SGD DESC:GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport Gene:HOS1(YPR068C)|FD-Score:3.57|P-value:1.77E-4||SGD DESC:Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex Gene:IES4(YOR189W)|FD-Score:3.31|P-value:4.71E-4||SGD DESC:Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses Gene:LAA1(YJL207C)|FD-Score:-3.35|P-value:4.00E-4||SGD DESC:AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene Gene:MCH4(YOL119C)|FD-Score:4.35|P-value:6.81E-6||SGD DESC:Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport Gene:MMR1(YLR190W)|FD-Score:4.9|P-value:4.69E-7||SGD DESC:Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p Gene:MNN5(YJL186W)|FD-Score:4.69|P-value:1.39E-6||SGD DESC:Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment Gene:MRH1(YDR033W)|FD-Score:3.33|P-value:4.29E-4||SGD DESC:Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; MRH1 has a paralog, YRO2, that arose from the whole genome duplication Gene:MRPL10(YNL284C)|FD-Score:3.25|P-value:5.74E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels Gene:MRPS17(YMR188C)|FD-Score:4.15|P-value:1.64E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MTG1(YMR097C)|FD-Score:3.44|P-value:2.92E-4||SGD DESC:Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals Gene:MUK1(YPL070W)|FD-Score:4.16|P-value:1.57E-5||SGD DESC:Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation Gene:NPP2(YEL016C)|FD-Score:-4.08|P-value:2.21E-5||SGD DESC:Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication Gene:PET112(YBL080C)|FD-Score:4.25|P-value:1.09E-5||SGD DESC:Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog Gene:PHR1(YOR386W)|FD-Score:3.46|P-value:2.70E-4||SGD DESC:DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p Gene:PTC1(YDL006W)|FD-Score:5.21|P-value:9.61E-8||SGD DESC:Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation Gene:RAD51(YER095W)|FD-Score:3.41|P-value:3.28E-4||SGD DESC:Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein Gene:RAS2(YNL098C)|FD-Score:3.1|P-value:9.69E-4||SGD DESC:GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes Gene:RBK1(YCR036W)|FD-Score:3.1|P-value:9.58E-4||SGD DESC:Putative ribokinase Gene:RGL1(YPL066W)|FD-Score:4.65|P-value:1.62E-6||SGD DESC:Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source Gene:RPL20A(YMR242C)|FD-Score:4.3|P-value:8.45E-6||SGD DESC:Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication Gene:RPL7B(YPL198W)|FD-Score:3.9|P-value:4.82E-5||SGD DESC:Ribosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication Gene:RTT101(YJL047C)|FD-Score:4.08|P-value:2.25E-5||SGD DESC:Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p Gene:SEC66(YBR171W)|FD-Score:4.27|P-value:9.69E-6||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SFM1(YOR021C)|FD-Score:3.51|P-value:2.21E-4||SGD DESC:SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism Gene:SHE4(YOR035C)|FD-Score:3.13|P-value:8.84E-4||SGD DESC:Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization Gene:SNF2(YOR290C)|FD-Score:3.81|P-value:6.86E-5||SGD DESC:Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p Gene:SOL2(YCR073W-A)|FD-Score:5.64|P-value:8.58E-9||SGD DESC:Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication Gene:SRB8(YCR081W)|FD-Score:7.71|P-value:6.35E-15||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression Gene:TMA19(YKL056C)|FD-Score:3.2|P-value:6.84E-4||SGD DESC:Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress Gene:TOD6(YBL054W)|FD-Score:-3.29|P-value:5.01E-4||SGD DESC:PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; TOD6 has a paralog, DOT6, that arose from the whole genome duplication Gene:TRM12(YML005W)|FD-Score:-3.44|P-value:2.88E-4||SGD DESC:S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA Gene:TRP4(YDR354W)|FD-Score:5.18|P-value:1.09E-7||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:VBA5(YKR105C_p)|FD-Score:-3.39|P-value:3.50E-4||SGD DESC:Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; similar to Vba3p Gene:YDR467C(YDR467C_d)|FD-Score:4.53|P-value:2.90E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YER121W(YER121W_p)|FD-Score:4.32|P-value:7.95E-6||SGD DESC:Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy Gene:YKL115C(YKL115C_d)|FD-Score:4.81|P-value:7.37E-7||SGD DESC:Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1 Gene:YLR030W(YLR030W_p)|FD-Score:-4.31|P-value:8.15E-6||SGD DESC:Putative protein of unknown function Gene:YLR455W(YLR455W_p)|FD-Score:4.1|P-value:2.08E-5||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); protein abundance increases in response to DNA replication stress Gene:YME2(YMR302C)|FD-Score:3.75|P-value:8.84E-5||SGD DESC:Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases Gene:YMR272W-B(YMR272W-B_p)|FD-Score:3.78|P-value:7.83E-5||SGD DESC:Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YNL195C(YNL195C_p)|FD-Score:3.72|P-value:9.89E-5||SGD DESC:Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YOR097C(YOR097C_p)|FD-Score:3.18|P-value:7.34E-4||SGD DESC:Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene Gene:YPR123C(YPR123C_d)|FD-Score:4.05|P-value:2.55E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR Gene:YPT7(YML001W)|FD-Score:3.2|P-value:6.90E-4||SGD DESC:Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7 Gene:ZRG8(YER033C)|FD-Score:3.45|P-value:2.84E-4||SGD DESC:Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGR128C6.163.69E-101.19UTP8Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YDR324C4.973.37E-70.44UTP4Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript
YIL022W4.532.95E-60.62TIM44Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
YPR112C3.914.65E-50.19MRD1Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region
YOR206W3.721.00E-40.38NOC2Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors
YNL002C3.344.14E-40.13RLP7Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs
YBR160W3.226.51E-40.03CDC28Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates; involved in modulating membrane trafficking dynamics; protein abundance increases in response to DNA replication stress
YBR002C3.197.16E-40.02RER2Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting
YBR234C3.177.73E-40.01ARC40Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
YKR083C3.167.99E-40.06DAD2Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YMR277W3.109.69E-40.02FCP1Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)
YMR218C3.080.001030.13TRS130One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy
YPL011C2.960.001560.09TAF3TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
YLR275W2.870.002050.04SMD2Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2
YFL045C2.830.002360.08SEC53Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YCR081W7.716.35E-15SRB8Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression
YBL085W6.351.10E-10BOI1Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
YCR073W-A5.648.58E-9SOL2Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication
YDL006W5.219.61E-8PTC1Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation
YDR354W5.181.09E-7TRP4Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
YLR190W4.904.69E-7MMR1Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
YKL115C_d4.817.37E-7YKL115C_dDubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
YJL186W4.691.39E-6MNN5Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
YPL066W4.651.62E-6RGL1Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source
YGR068C4.572.46E-6ART5Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane
YDR467C_d4.532.90E-6YDR467C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHL031C4.513.26E-6GOS1v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28
YOL119C4.356.81E-6MCH4Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YER121W_p4.327.95E-6YER121W_pPutative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
YMR242C4.308.45E-6RPL20ARibosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication

GO enrichment analysis for SGTC_1116
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.0992.17E-14SGTC_2741miltefosine 3.0 μMMiscellaneous35990.0689655
0.0943.64E-13SGTC_14740330-0125 5.3 μMChemDiv (Drug-like library)X14740.0869565
0.0854.75E-11SGTC_1520flindersine 88.0 μMTimTec (Pure natural product library)682300.0625
0.0823.31E-10SGTC_30249090631 49.5 μMChembridge (Drug-like library)252363830.117647
0.0782.32E-9SGTC_2673kobusone 100.0 μMMicrosource (Natural product library)67106760.178571
0.0772.91E-9SGTC_190279-0214 38.4 μMChemDiv (Drug-like library)35662740.0535714TRP & mitochondrial translation
0.0757.43E-9SGTC_305-(2-thienylidene)-Rhodanine 28.7 μMChemDiv (Drug-like library)12411320.0645161
0.0741.02E-8SGTC_30919116372 49.5 μMChembridge (Drug-like library)171697930.0895522
0.0731.64E-8SGTC_2726cimetidine 79.3 μMMiscellaneous27560.0547945
0.0731.82E-8SGTC_100279-0212 42.6 μMChemDiv (Drug-like library)398510.0535714TRP & mitochondrial translation
0.0732.05E-8SGTC_31769106582 49.5 μMChembridge (Drug-like library)170180270.0746269
0.0707.20E-8SGTC_790052-0007 94.1 μMChemDiv (Drug-like library)28014720.178571
0.0691.34E-7SGTC_1093fluphenazine 8.0 μMNIH Clinical Collection66026110.0533333
0.0672.93E-7SGTC_29959067767 71.4 μMChembridge (Drug-like library)116735670.0735294
0.0664.58E-7SGTC_7273032-0951 202.0 μMChemDiv (Drug-like library)36528360.0571429

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_410α-linolenic acid100 μM0.297872860Miscellaneous278.42965.97112excess fatty acid
SGTC_475α-linolenic acid10 μM0.2978725280934ICCB bioactive library278.42965.97112excess fatty acid
SGTC_2631bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone100 μM0.2523847180Microsource (Natural product library)399.319283.40914
SGTC_409arachidonic acid100 μM0.22449231Miscellaneous304.466886.43912
SGTC_476mead acid10 μM0.225312531ICCB bioactive library306.482766.88312
SGTC_2004402372841.89 μM0.212766360084Chembridge (Fragment library)177.671741.2912
SGTC_2655perillic acid100 μM0.2115385702197Microsource (Natural product library)166.216962.64612
SGTC_10441222-00211.78 μM0.1967214306703ChemDiv (Drug-like library)261.359324.54913heme biosynthesis & mitochondrial translocase
SGTC_478N-arachidonylglycine10 μM0.1964295283389ICCB bioactive library361.51825.49923
SGTC_479n-linoleoylglycine10 μM0.1929826433346ICCB bioactive library337.49685.47623
SGTC_1646st01170975.6 μM0.1929825757843TimTec (Natural product derivative library)233.306162.50112