Deletion Strain | FD score | P-value | Gene | Gene Description |
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YCR081W | 7.71 | 6.35E-15 | SRB8 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression |
YBL085W | 6.35 | 1.10E-10 | BOI1 | Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication |
YCR073W-A | 5.64 | 8.58E-9 | SOL2 | Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication |
YDL006W | 5.21 | 9.61E-8 | PTC1 | Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation |
YDR354W | 5.18 | 1.09E-7 | TRP4 | Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis |
YLR190W | 4.90 | 4.69E-7 | MMR1 | Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p |
YKL115C_d | 4.81 | 7.37E-7 | YKL115C_d | Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1 |
YJL186W | 4.69 | 1.39E-6 | MNN5 | Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment |
YPL066W | 4.65 | 1.62E-6 | RGL1 | Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source |
YGR068C | 4.57 | 2.46E-6 | ART5 | Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane |
YDR467C_d | 4.53 | 2.90E-6 | YDR467C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YHL031C | 4.51 | 3.26E-6 | GOS1 | v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28 |
YOL119C | 4.35 | 6.81E-6 | MCH4 | Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport |
YER121W_p | 4.32 | 7.95E-6 | YER121W_p | Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy |
YMR242C | 4.30 | 8.45E-6 | RPL20A | Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication |