capsaicin FDA approved compound

(E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide

An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.

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PubChem MeSH terms: Antipruritics;Sensory System Agents



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1122
Screen concentration 818.6 nM
Source TimTec (Natural product library)
PubChem CID 1548943
SMILES CC(C)C=CCCCCC(=O)NCC1=CC(=C(C=C1)O)OC
Standardized SMILES COc1cc(CNC(=O)CCCCC=CC(C)C)ccc1O
Molecular weight 305.4119
ALogP 3.91
H-bond donor count 2
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 5.46
% growth inhibition (Hom. pool) 5.01


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 1548943
Download HIP data (tab-delimited text)  (excel)
Gene:ARH1(YDR376W)|FD-Score:3.4|P-value:3.32E-4|Clearance:0.13||SGD DESC:Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability Gene:BET4(YJL031C)|FD-Score:3.62|P-value:1.48E-4|Clearance:0.08||SGD DESC:Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p Gene:CDC16(YKL022C)|FD-Score:4.13|P-value:1.83E-5|Clearance:0.03||SGD DESC:Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation Gene:CDC6(YJL194W)|FD-Score:3.81|P-value:6.83E-5|Clearance:0.2||SGD DESC:Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:ECM16(YMR128W)|FD-Score:-3.43|P-value:2.96E-4|Clearance:0||SGD DESC:Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis Gene:FRQ1(YDR373W)|FD-Score:3.19|P-value:7.05E-4|Clearance:0.01||SGD DESC:N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily Gene:GUS1(YGL245W)|FD-Score:3.27|P-value:5.36E-4|Clearance:0.08||SGD DESC:Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress Gene:MAK11(YKL021C)|FD-Score:4.04|P-value:2.67E-5|Clearance:0.23||SGD DESC:Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats Gene:NAR1(YNL240C)|FD-Score:3.18|P-value:7.33E-4|Clearance:0.07||SGD DESC:Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf Gene:PRP3(YDR473C)|FD-Score:3.47|P-value:2.61E-4|Clearance:0.02||SGD DESC:Splicing factor, component of the U4/U6-U5 snRNP complex Gene:PRP9(YDL030W)|FD-Score:4.66|P-value:1.60E-6|Clearance:0.53||SGD DESC:Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex Gene:RPL30(YGL030W)|FD-Score:3.54|P-value:1.99E-4|Clearance:0.07||SGD DESC:Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog Gene:RSC6(YCR052W)|FD-Score:-3.51|P-value:2.27E-4|Clearance:0||SGD DESC:Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p Gene:SLD5(YDR489W)|FD-Score:3.11|P-value:9.40E-4|Clearance:0.09||SGD DESC:Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery Gene:SPT5(YML010W)|FD-Score:-4.53|P-value:2.94E-6|Clearance:0||SGD DESC:Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair Gene:STH1(YIL126W)|FD-Score:3.45|P-value:2.79E-4|Clearance:0.05||SGD DESC:ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p Gene:STS1(YIR011C)|FD-Score:-3.43|P-value:3.05E-4|Clearance:0||SGD DESC:Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation Gene:TBF1(YPL128C)|FD-Score:4.1|P-value:2.05E-5|Clearance:0.06||SGD DESC:Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation Gene:ARH1(YDR376W)|FD-Score:3.4|P-value:3.32E-4|Clearance:0.13||SGD DESC:Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability Gene:BET4(YJL031C)|FD-Score:3.62|P-value:1.48E-4|Clearance:0.08||SGD DESC:Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p Gene:CDC16(YKL022C)|FD-Score:4.13|P-value:1.83E-5|Clearance:0.03||SGD DESC:Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation Gene:CDC6(YJL194W)|FD-Score:3.81|P-value:6.83E-5|Clearance:0.2||SGD DESC:Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:ECM16(YMR128W)|FD-Score:-3.43|P-value:2.96E-4|Clearance:0||SGD DESC:Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis Gene:FRQ1(YDR373W)|FD-Score:3.19|P-value:7.05E-4|Clearance:0.01||SGD DESC:N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily Gene:GUS1(YGL245W)|FD-Score:3.27|P-value:5.36E-4|Clearance:0.08||SGD DESC:Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress Gene:MAK11(YKL021C)|FD-Score:4.04|P-value:2.67E-5|Clearance:0.23||SGD DESC:Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats Gene:NAR1(YNL240C)|FD-Score:3.18|P-value:7.33E-4|Clearance:0.07||SGD DESC:Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf Gene:PRP3(YDR473C)|FD-Score:3.47|P-value:2.61E-4|Clearance:0.02||SGD DESC:Splicing factor, component of the U4/U6-U5 snRNP complex Gene:PRP9(YDL030W)|FD-Score:4.66|P-value:1.60E-6|Clearance:0.53||SGD DESC:Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex Gene:RPL30(YGL030W)|FD-Score:3.54|P-value:1.99E-4|Clearance:0.07||SGD DESC:Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog Gene:RSC6(YCR052W)|FD-Score:-3.51|P-value:2.27E-4|Clearance:0||SGD DESC:Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p Gene:SLD5(YDR489W)|FD-Score:3.11|P-value:9.40E-4|Clearance:0.09||SGD DESC:Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery Gene:SPT5(YML010W)|FD-Score:-4.53|P-value:2.94E-6|Clearance:0||SGD DESC:Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair Gene:STH1(YIL126W)|FD-Score:3.45|P-value:2.79E-4|Clearance:0.05||SGD DESC:ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p Gene:STS1(YIR011C)|FD-Score:-3.43|P-value:3.05E-4|Clearance:0||SGD DESC:Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation Gene:TBF1(YPL128C)|FD-Score:4.1|P-value:2.05E-5|Clearance:0.06||SGD DESC:Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 1548943
Download HOP data (tab-delimited text)  (excel)
Gene:ACB1(YGR037C)|FD-Score:3.28|P-value:5.27E-4||SGD DESC:Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress Gene:ADE5,7(YGL234W)|FD-Score:3.86|P-value:5.65E-5||SGD DESC:Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities Gene:AHC1(YOR023C)|FD-Score:-3.65|P-value:1.32E-4||SGD DESC:Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex Gene:AKL1(YBR059C)|FD-Score:3.95|P-value:3.93E-5||SGD DESC:Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization Gene:ANT1(YPR128C)|FD-Score:3.31|P-value:4.72E-4||SGD DESC:Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation Gene:APL3(YBL037W)|FD-Score:5.47|P-value:2.21E-8||SGD DESC:Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport Gene:APM3(YBR288C)|FD-Score:4.04|P-value:2.66E-5||SGD DESC:Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway Gene:BIO5(YNR056C)|FD-Score:3.17|P-value:7.53E-4||SGD DESC:Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis Gene:CPR8(YNR028W)|FD-Score:4.8|P-value:7.82E-7||SGD DESC:Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway Gene:CPS1(YJL172W)|FD-Score:6.71|P-value:9.42E-12||SGD DESC:Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions Gene:CSF1(YLR087C)|FD-Score:-3.82|P-value:6.80E-5||SGD DESC:Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:CUE5(YOR042W)|FD-Score:-3.48|P-value:2.51E-4||SGD DESC:Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:DBP7(YKR024C)|FD-Score:4.07|P-value:2.37E-5||SGD DESC:Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions Gene:DMA1(YHR115C)|FD-Score:3.8|P-value:7.18E-5||SGD DESC:Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma2p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8 protein, similar to human Chfr; contains FHA and RING finger Gene:ECM5(YMR176W)|FD-Score:3.21|P-value:6.63E-4||SGD DESC:Non-essential protein of unknown function; contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress Gene:EFM1(YHL039W)|FD-Score:3.12|P-value:9.03E-4||SGD DESC:Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:ERV25(YML012W)|FD-Score:8.17|P-value:1.55E-16||SGD DESC:Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport Gene:ETR1(YBR026C)|FD-Score:3.47|P-value:2.65E-4||SGD DESC:2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis Gene:FAA2(YER015W)|FD-Score:3.36|P-value:3.93E-4||SGD DESC:Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome Gene:FMP16(YDR070C_p)|FD-Score:3.19|P-value:7.12E-4||SGD DESC:Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress Gene:FRE3(YOR381W)|FD-Score:3.77|P-value:8.02E-5||SGD DESC:Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels Gene:FYV8(YGR196C)|FD-Score:-3.18|P-value:7.37E-4||SGD DESC:Protein of unknown function, required for survival upon exposure to K1 killer toxin Gene:GAL83(YER027C)|FD-Score:-4.82|P-value:7.15E-7||SGD DESC:One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain Gene:HLR1(YDR528W)|FD-Score:4.15|P-value:1.63E-5||SGD DESC:Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A; <br>HLR1 has a paralog, LRE1, that arose from the whole genome duplication Gene:HPF1(YOL155C)|FD-Score:3.12|P-value:9.06E-4||SGD DESC:Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines Gene:HST2(YPL015C)|FD-Score:-3.82|P-value:6.61E-5||SGD DESC:Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export Gene:IRC18(YJL037W)|FD-Score:3.35|P-value:4.08E-4||SGD DESC:Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci Gene:IST3(YIR005W)|FD-Score:-3.79|P-value:7.52E-5||SGD DESC:Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing Gene:JJJ1(YNL227C)|FD-Score:-4.28|P-value:9.31E-6||SGD DESC:Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis Gene:KEL2(YGR238C)|FD-Score:-3.16|P-value:7.99E-4||SGD DESC:Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate Gene:LAG2(YOL025W)|FD-Score:-3.28|P-value:5.17E-4||SGD DESC:Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1 Gene:LAT1(YNL071W)|FD-Score:5.13|P-value:1.44E-7||SGD DESC:Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA Gene:LEA1(YPL213W)|FD-Score:4.45|P-value:4.24E-6||SGD DESC:Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein Gene:LSB6(YJL100W)|FD-Score:-4.2|P-value:1.32E-5||SGD DESC:Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization Gene:MDL2(YPL270W)|FD-Score:3.84|P-value:6.12E-5||SGD DESC:Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis Gene:MRPL35(YDR322W)|FD-Score:3.11|P-value:9.33E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL37(YBR268W)|FD-Score:3.16|P-value:7.91E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL49(YJL096W)|FD-Score:4.97|P-value:3.37E-7||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MSH3(YCR092C)|FD-Score:4.06|P-value:2.50E-5||SGD DESC:Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability Gene:MST1(YKL194C)|FD-Score:5.35|P-value:4.37E-8||SGD DESC:Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro Gene:NAM2(YLR382C)|FD-Score:-4.45|P-value:4.32E-6||SGD DESC:Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance Gene:NGG1(YDR176W)|FD-Score:4.24|P-value:1.12E-5||SGD DESC:Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex Gene:PDE2(YOR360C)|FD-Score:3.26|P-value:5.53E-4||SGD DESC:High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon Gene:PET111(YMR257C)|FD-Score:3.54|P-value:2.03E-4||SGD DESC:Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane Gene:PEX11(YOL147C)|FD-Score:-4.24|P-value:1.10E-5||SGD DESC:Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p Gene:PMT7(YDR307W_p)|FD-Score:4.03|P-value:2.78E-5||SGD DESC:Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation Gene:QCR6(YFR033C)|FD-Score:3.32|P-value:4.50E-4||SGD DESC:Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space Gene:ROM2(YLR371W)|FD-Score:4.06|P-value:2.41E-5||SGD DESC:GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p Gene:RPL31B(YLR406C)|FD-Score:3.31|P-value:4.67E-4||SGD DESC:Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication Gene:RPS17B(YDR447C)|FD-Score:3.19|P-value:7.11E-4||SGD DESC:Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:RUP1(YOR138C)|FD-Score:3.11|P-value:9.46E-4||SGD DESC:Protein that regulates Rsp5p, which is a HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress Gene:SHE2(YKL130C)|FD-Score:3.62|P-value:1.49E-4||SGD DESC:RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud Gene:SNX3(YOR357C)|FD-Score:4.5|P-value:3.38E-6||SGD DESC:Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p Gene:SPG1(YGR236C)|FD-Score:4.46|P-value:4.13E-6||SGD DESC:Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:SSD1(YDR293C)|FD-Score:3.44|P-value:2.87E-4||SGD DESC:Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function Gene:SSM4(YIL030C)|FD-Score:3.94|P-value:4.11E-5||SGD DESC:Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation Gene:SSN2(YDR443C)|FD-Score:-3.12|P-value:9.09E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation Gene:STR2(YJR130C)|FD-Score:3.31|P-value:4.65E-4||SGD DESC:Cystathionine gamma-synthase, converts cysteine into cystathionine Gene:SWM2(YNR004W_p)|FD-Score:5.27|P-value:6.89E-8||SGD DESC:Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds Gene:THO2(YNL139C)|FD-Score:5.34|P-value:4.55E-8||SGD DESC:Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids Gene:TRP4(YDR354W)|FD-Score:4.75|P-value:1.02E-6||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:VAM10(YOR068C)|FD-Score:3.69|P-value:1.12E-4||SGD DESC:Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering Gene:VHR2(YER064C_p)|FD-Score:-3.81|P-value:6.83E-5||SGD DESC:Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:YBL012C(YBL012C_d)|FD-Score:3.18|P-value:7.27E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YCR087W(YCR087W_d)|FD-Score:-3.13|P-value:8.80E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene Gene:YDR095C(YDR095C_d)|FD-Score:3.95|P-value:3.97E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YDR524W-C(YDR524W-C_p)|FD-Score:3.46|P-value:2.70E-4||SGD DESC:Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin Gene:YGR017W(YGR017W_p)|FD-Score:3.86|P-value:5.68E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm Gene:YGR045C(YGR045C_d)|FD-Score:3.9|P-value:4.81E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YHR003C(YHR003C)|FD-Score:-3.25|P-value:5.67E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YHR080C(YHR080C)|FD-Score:5.43|P-value:2.75E-8||SGD DESC:Protein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication Gene:YHR139C-A(YHR139C-A_d)|FD-Score:-4.33|P-value:7.50E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJR056C(YJR056C_p)|FD-Score:-3.27|P-value:5.47E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress Gene:YKL053W(YKL053W_d)|FD-Score:3.18|P-value:7.34E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1 Gene:YLR177W(YLR177W_p)|FD-Score:5.58|P-value:1.18E-8||SGD DESC:Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication Gene:YLR334C(YLR334C_d)|FD-Score:3.35|P-value:4.10E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here Gene:YLR412C-A(YLR412C-A_p)|FD-Score:4.97|P-value:3.43E-7||SGD DESC:Putative protein of unknown function Gene:YOL013W-A(YOL013W-A_p)|FD-Score:4.31|P-value:7.99E-6||SGD DESC:Putative protein of unknown function; identified by SAGE Gene:YOL038C-A(YOL038C-A_p)|FD-Score:3.47|P-value:2.59E-4||SGD DESC:Putative protein of unknown function; identified by SAGE analysis Gene:YOL057W(YOL057W)|FD-Score:-3.22|P-value:6.35E-4||SGD DESC:Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers Gene:YOR366W(YOR366W_d)|FD-Score:5.4|P-value:3.32E-8||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C Gene:YPR012W(YPR012W_d)|FD-Score:3.78|P-value:7.91E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene Gene:YPR117W(YPR117W_p)|FD-Score:5.52|P-value:1.66E-8||SGD DESC:Putative protein of unknown function Gene:ZRG8(YER033C)|FD-Score:3.56|P-value:1.86E-4||SGD DESC:Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency Gene:ACB1(YGR037C)|FD-Score:3.28|P-value:5.27E-4||SGD DESC:Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress Gene:ADE5,7(YGL234W)|FD-Score:3.86|P-value:5.65E-5||SGD DESC:Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities Gene:AHC1(YOR023C)|FD-Score:-3.65|P-value:1.32E-4||SGD DESC:Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex Gene:AKL1(YBR059C)|FD-Score:3.95|P-value:3.93E-5||SGD DESC:Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization Gene:ANT1(YPR128C)|FD-Score:3.31|P-value:4.72E-4||SGD DESC:Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation Gene:APL3(YBL037W)|FD-Score:5.47|P-value:2.21E-8||SGD DESC:Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport Gene:APM3(YBR288C)|FD-Score:4.04|P-value:2.66E-5||SGD DESC:Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway Gene:BIO5(YNR056C)|FD-Score:3.17|P-value:7.53E-4||SGD DESC:Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis Gene:CPR8(YNR028W)|FD-Score:4.8|P-value:7.82E-7||SGD DESC:Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway Gene:CPS1(YJL172W)|FD-Score:6.71|P-value:9.42E-12||SGD DESC:Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions Gene:CSF1(YLR087C)|FD-Score:-3.82|P-value:6.80E-5||SGD DESC:Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:CUE5(YOR042W)|FD-Score:-3.48|P-value:2.51E-4||SGD DESC:Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:DBP7(YKR024C)|FD-Score:4.07|P-value:2.37E-5||SGD DESC:Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions Gene:DMA1(YHR115C)|FD-Score:3.8|P-value:7.18E-5||SGD DESC:Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma2p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8 protein, similar to human Chfr; contains FHA and RING finger Gene:ECM5(YMR176W)|FD-Score:3.21|P-value:6.63E-4||SGD DESC:Non-essential protein of unknown function; contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress Gene:EFM1(YHL039W)|FD-Score:3.12|P-value:9.03E-4||SGD DESC:Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:ERV25(YML012W)|FD-Score:8.17|P-value:1.55E-16||SGD DESC:Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport Gene:ETR1(YBR026C)|FD-Score:3.47|P-value:2.65E-4||SGD DESC:2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis Gene:FAA2(YER015W)|FD-Score:3.36|P-value:3.93E-4||SGD DESC:Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome Gene:FMP16(YDR070C_p)|FD-Score:3.19|P-value:7.12E-4||SGD DESC:Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress Gene:FRE3(YOR381W)|FD-Score:3.77|P-value:8.02E-5||SGD DESC:Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels Gene:FYV8(YGR196C)|FD-Score:-3.18|P-value:7.37E-4||SGD DESC:Protein of unknown function, required for survival upon exposure to K1 killer toxin Gene:GAL83(YER027C)|FD-Score:-4.82|P-value:7.15E-7||SGD DESC:One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain Gene:HLR1(YDR528W)|FD-Score:4.15|P-value:1.63E-5||SGD DESC:Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A; <br>HLR1 has a paralog, LRE1, that arose from the whole genome duplication Gene:HPF1(YOL155C)|FD-Score:3.12|P-value:9.06E-4||SGD DESC:Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines Gene:HST2(YPL015C)|FD-Score:-3.82|P-value:6.61E-5||SGD DESC:Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export Gene:IRC18(YJL037W)|FD-Score:3.35|P-value:4.08E-4||SGD DESC:Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci Gene:IST3(YIR005W)|FD-Score:-3.79|P-value:7.52E-5||SGD DESC:Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing Gene:JJJ1(YNL227C)|FD-Score:-4.28|P-value:9.31E-6||SGD DESC:Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis Gene:KEL2(YGR238C)|FD-Score:-3.16|P-value:7.99E-4||SGD DESC:Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate Gene:LAG2(YOL025W)|FD-Score:-3.28|P-value:5.17E-4||SGD DESC:Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1 Gene:LAT1(YNL071W)|FD-Score:5.13|P-value:1.44E-7||SGD DESC:Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA Gene:LEA1(YPL213W)|FD-Score:4.45|P-value:4.24E-6||SGD DESC:Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein Gene:LSB6(YJL100W)|FD-Score:-4.2|P-value:1.32E-5||SGD DESC:Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization Gene:MDL2(YPL270W)|FD-Score:3.84|P-value:6.12E-5||SGD DESC:Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis Gene:MRPL35(YDR322W)|FD-Score:3.11|P-value:9.33E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL37(YBR268W)|FD-Score:3.16|P-value:7.91E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL49(YJL096W)|FD-Score:4.97|P-value:3.37E-7||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MSH3(YCR092C)|FD-Score:4.06|P-value:2.50E-5||SGD DESC:Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability Gene:MST1(YKL194C)|FD-Score:5.35|P-value:4.37E-8||SGD DESC:Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro Gene:NAM2(YLR382C)|FD-Score:-4.45|P-value:4.32E-6||SGD DESC:Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance Gene:NGG1(YDR176W)|FD-Score:4.24|P-value:1.12E-5||SGD DESC:Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex Gene:PDE2(YOR360C)|FD-Score:3.26|P-value:5.53E-4||SGD DESC:High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon Gene:PET111(YMR257C)|FD-Score:3.54|P-value:2.03E-4||SGD DESC:Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane Gene:PEX11(YOL147C)|FD-Score:-4.24|P-value:1.10E-5||SGD DESC:Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p Gene:PMT7(YDR307W_p)|FD-Score:4.03|P-value:2.78E-5||SGD DESC:Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation Gene:QCR6(YFR033C)|FD-Score:3.32|P-value:4.50E-4||SGD DESC:Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space Gene:ROM2(YLR371W)|FD-Score:4.06|P-value:2.41E-5||SGD DESC:GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p Gene:RPL31B(YLR406C)|FD-Score:3.31|P-value:4.67E-4||SGD DESC:Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication Gene:RPS17B(YDR447C)|FD-Score:3.19|P-value:7.11E-4||SGD DESC:Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:RUP1(YOR138C)|FD-Score:3.11|P-value:9.46E-4||SGD DESC:Protein that regulates Rsp5p, which is a HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress Gene:SHE2(YKL130C)|FD-Score:3.62|P-value:1.49E-4||SGD DESC:RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud Gene:SNX3(YOR357C)|FD-Score:4.5|P-value:3.38E-6||SGD DESC:Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p Gene:SPG1(YGR236C)|FD-Score:4.46|P-value:4.13E-6||SGD DESC:Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:SSD1(YDR293C)|FD-Score:3.44|P-value:2.87E-4||SGD DESC:Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function Gene:SSM4(YIL030C)|FD-Score:3.94|P-value:4.11E-5||SGD DESC:Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation Gene:SSN2(YDR443C)|FD-Score:-3.12|P-value:9.09E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation Gene:STR2(YJR130C)|FD-Score:3.31|P-value:4.65E-4||SGD DESC:Cystathionine gamma-synthase, converts cysteine into cystathionine Gene:SWM2(YNR004W_p)|FD-Score:5.27|P-value:6.89E-8||SGD DESC:Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds Gene:THO2(YNL139C)|FD-Score:5.34|P-value:4.55E-8||SGD DESC:Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids Gene:TRP4(YDR354W)|FD-Score:4.75|P-value:1.02E-6||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:VAM10(YOR068C)|FD-Score:3.69|P-value:1.12E-4||SGD DESC:Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering Gene:VHR2(YER064C_p)|FD-Score:-3.81|P-value:6.83E-5||SGD DESC:Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:YBL012C(YBL012C_d)|FD-Score:3.18|P-value:7.27E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YCR087W(YCR087W_d)|FD-Score:-3.13|P-value:8.80E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene Gene:YDR095C(YDR095C_d)|FD-Score:3.95|P-value:3.97E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YDR524W-C(YDR524W-C_p)|FD-Score:3.46|P-value:2.70E-4||SGD DESC:Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin Gene:YGR017W(YGR017W_p)|FD-Score:3.86|P-value:5.68E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm Gene:YGR045C(YGR045C_d)|FD-Score:3.9|P-value:4.81E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YHR003C(YHR003C)|FD-Score:-3.25|P-value:5.67E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YHR080C(YHR080C)|FD-Score:5.43|P-value:2.75E-8||SGD DESC:Protein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication Gene:YHR139C-A(YHR139C-A_d)|FD-Score:-4.33|P-value:7.50E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJR056C(YJR056C_p)|FD-Score:-3.27|P-value:5.47E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress Gene:YKL053W(YKL053W_d)|FD-Score:3.18|P-value:7.34E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1 Gene:YLR177W(YLR177W_p)|FD-Score:5.58|P-value:1.18E-8||SGD DESC:Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication Gene:YLR334C(YLR334C_d)|FD-Score:3.35|P-value:4.10E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here Gene:YLR412C-A(YLR412C-A_p)|FD-Score:4.97|P-value:3.43E-7||SGD DESC:Putative protein of unknown function Gene:YOL013W-A(YOL013W-A_p)|FD-Score:4.31|P-value:7.99E-6||SGD DESC:Putative protein of unknown function; identified by SAGE Gene:YOL038C-A(YOL038C-A_p)|FD-Score:3.47|P-value:2.59E-4||SGD DESC:Putative protein of unknown function; identified by SAGE analysis Gene:YOL057W(YOL057W)|FD-Score:-3.22|P-value:6.35E-4||SGD DESC:Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers Gene:YOR366W(YOR366W_d)|FD-Score:5.4|P-value:3.32E-8||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C Gene:YPR012W(YPR012W_d)|FD-Score:3.78|P-value:7.91E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene Gene:YPR117W(YPR117W_p)|FD-Score:5.52|P-value:1.66E-8||SGD DESC:Putative protein of unknown function Gene:ZRG8(YER033C)|FD-Score:3.56|P-value:1.86E-4||SGD DESC:Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YDL030W4.661.60E-60.53PRP9Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex
YKL022C4.131.83E-50.03CDC16Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation
YPL128C4.102.05E-50.06TBF1Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation
YKL021C4.042.67E-50.23MAK11Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
YJL194W3.816.83E-50.20CDC6Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress
YJL031C3.621.48E-40.08BET4Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
YGL030W3.541.99E-40.07RPL30Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog
YDR473C3.472.61E-40.02PRP3Splicing factor, component of the U4/U6-U5 snRNP complex
YIL126W3.452.79E-40.05STH1ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
YDR376W3.403.32E-40.13ARH1Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
YGL245W3.275.36E-40.08GUS1Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress
YDR373W3.197.05E-40.01FRQ1N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily
YNL240C3.187.33E-40.07NAR1Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf
YDR489W3.119.40E-40.09SLD5Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
YGR065C3.020.001280.03VHT1High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YML012W8.171.55E-16ERV25Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport
YJL172W6.719.42E-12CPS1Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions
YLR177W_p5.581.18E-8YLR177W_pPutative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication
YPR117W_p5.521.66E-8YPR117W_pPutative protein of unknown function
YBL037W5.472.21E-8APL3Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport
YHR080C5.432.75E-8YHR080CProtein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication
YOR366W_d5.403.32E-8YOR366W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C
YKL194C5.354.37E-8MST1Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
YNL139C5.344.55E-8THO2Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids
YNR004W_p5.276.89E-8SWM2_pPutative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds
YNL071W5.131.44E-7LAT1Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA
YJL096W4.973.37E-7MRPL49Mitochondrial ribosomal protein of the large subunit
YLR412C-A_p4.973.43E-7YLR412C-A_pPutative protein of unknown function
YNR028W4.807.82E-7CPR8Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
YDR354W4.751.02E-6TRP4Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis

GO enrichment analysis for SGTC_1122
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.0723.29E-8SGTC_1778st046819 58.9 μMTimTec (Natural product derivative library)6717150.144578
0.0681.68E-7SGTC_1135dihydrocapsaicin 536.7 nMTimTec (Natural product library)1079820.698113
0.0663.45E-7SGTC_21625663267 200.0 μMChembridge (Fragment library)64564930.180556
0.0621.83E-6SGTC_33449148862 3.9 μMChembridge (Drug-like library)49053520.103448
0.0603.93E-6SGTC_1136pergolide 1.1 μMTimTec (Natural product library)478110.0543478
0.0571.07E-5SGTC_1076itraconazole 331.0 nMMiscellaneous37930.0847458
0.0561.57E-5SGTC_13611608-0041 5.6 μMChemDiv (Drug-like library)X13610.0945946RPP1 & pyrimidine depletion
0.0552.17E-5SGTC_247mechlorethamine 29.7 μMMiscellaneous221335930.0350877DNA damage response
0.0552.29E-5SGTC_1114scopoletin 1.7 μMTimTec (Natural product library)52804600.222222
0.0552.72E-5SGTC_20305175110 200.0 μMChembridge (Fragment library)28319860.134328Golgi
0.0535.00E-5SGTC_7211187-1332 279.0 μMChemDiv (Drug-like library)257300.115942cell wall signaling
0.0518.05E-5SGTC_21635671233 125.0 μMChembridge (Fragment library)7010230.0897436
0.0501.08E-4SGTC_14944358-1428 177.0 μMChemDiv (Drug-like library)15645710.141176
0.0501.24E-4SGTC_21375261020 140.0 μMChembridge (Fragment library)7636550.152778
0.0472.72E-4SGTC_18835-benzylidenerhodanine 20.0 μMMiscellaneous12732100.0714286TRP & mitochondrial translation

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_2684capsaicin100 μM11548943Miscellaneous305.411883.9123
SGTC_1135dihydrocapsaicin536.71 nM0.698113107982TimTec (Natural product library)307.427764.35423
SGTC_456gingerol170 μM0.4442793ICCB bioactive library294.385943.63824
SGTC_2669eugenol100 μM0.3888893314Microsource (Natural product library)164.201082.57912
SGTC_1925st05777010.1 μM0.3076925989122TimTec (Natural product derivative library)284.306543.68724TSC3-RPN4
SGTC_479n-linoleoylglycine10 μM0.3064526433346ICCB bioactive library337.49685.47623
SGTC_2851901592271.43 μM0.2985072996893Chembridge (Drug-like library)299.364243.31513
SGTC_478N-arachidonylglycine10 μM0.2903235283389ICCB bioactive library361.51825.49923
SGTC_3041310-029897 μM0.2857141550234ChemDiv (Drug-like library)366.407084.6225cell wall
SGTC_477mead ethanolamide10 μM0.28571416061185ICCB bioactive library349.550565.92222