Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
---|
YDL030W | 4.66 | 1.60E-6 | 0.53 | PRP9 | Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex |
YKL022C | 4.13 | 1.83E-5 | 0.03 | CDC16 | Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation |
YPL128C | 4.10 | 2.05E-5 | 0.06 | TBF1 | Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation |
YKL021C | 4.04 | 2.67E-5 | 0.23 | MAK11 | Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats |
YJL194W | 3.81 | 6.83E-5 | 0.20 | CDC6 | Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress |
YJL031C | 3.62 | 1.48E-4 | 0.08 | BET4 | Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p |
YGL030W | 3.54 | 1.99E-4 | 0.07 | RPL30 | Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog |
YDR473C | 3.47 | 2.61E-4 | 0.02 | PRP3 | Splicing factor, component of the U4/U6-U5 snRNP complex |
YIL126W | 3.45 | 2.79E-4 | 0.05 | STH1 | ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p |
YDR376W | 3.40 | 3.32E-4 | 0.13 | ARH1 | Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability |
YGL245W | 3.27 | 5.36E-4 | 0.08 | GUS1 | Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress |
YDR373W | 3.19 | 7.05E-4 | 0.01 | FRQ1 | N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily |
YNL240C | 3.18 | 7.33E-4 | 0.07 | NAR1 | Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf |
YDR489W | 3.11 | 9.40E-4 | 0.09 | SLD5 | Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery |
YGR065C | 3.02 | 0.00128 | 0.03 | VHT1 | High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin |