Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YBL026W | 9.24 | 1.21E-20 | 1.67 | LSM2 | Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress |
YMR203W | 7.57 | 1.86E-14 | 1.35 | TOM40 | Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore |
YJR007W | 6.22 | 2.45E-10 | 0.47 | SUI2 | Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress |
YPR165W | 5.76 | 4.29E-9 | 0.01 | RHO1 | GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) |
YNL110C | 5.75 | 4.50E-9 | 0.88 | NOP15 | Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm |
YGL048C | 4.87 | 5.62E-7 | 0.11 | RPT6 | ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress |
YMR277W | 4.76 | 9.68E-7 | 0.17 | FCP1 | Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p) |
YFL039C | 4.59 | 2.20E-6 | 0.11 | ACT1 | Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions |
YPL083C | 4.48 | 3.75E-6 | 0.32 | SEN54 | Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p |
YJL011C | 4.16 | 1.56E-5 | 0.28 | RPC17 | RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress |
YOL040C | 3.89 | 5.02E-5 | 0.29 | RPS15 | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19 |
YDR086C | 3.60 | 1.57E-4 | 0.09 | SSS1 | Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p |
YDL196W_d | 3.51 | 2.25E-4 | 0.12 | YDL196W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 |
YLR230W_d | 3.39 | 3.50E-4 | 0.23 | YLR230W_d | Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity |
YGR114C_d | 3.16 | 8.02E-4 | 0.04 | YGR114C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6 |