Deletion Strain | FD score | P-value | Gene | Gene Description |
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YER088C | 8.06 | 3.82E-16 | DOT6 | Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; DOT6 has a paralog, TOD6, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress |
YKL098W | 7.76 | 4.39E-15 | MTC2 | Protein of unknown function; mtc2 is synthetically sick with cdc13-1 |
YDL218W_p | 6.29 | 1.62E-10 | YDL218W_p | Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin |
YKR072C | 6.24 | 2.14E-10 | SIS2 | Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis |
YLR050C_p | 5.93 | 1.54E-9 | YLR050C_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene |
YBL012C_d | 5.88 | 2.08E-9 | YBL012C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YOR360C | 5.70 | 5.89E-9 | PDE2 | High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon |
YMR119W | 5.32 | 5.31E-8 | ASI1 | Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication |
YOR118W | 5.14 | 1.41E-7 | RTC5 | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity |
YER027C | 5.03 | 2.41E-7 | GAL83 | One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain |
YHR073W | 4.95 | 3.73E-7 | OSH3 | Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability |
YLR108C_p | 4.89 | 4.92E-7 | YLR108C_p | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication |
YCR066W | 4.85 | 6.08E-7 | RAD18 | E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA |
YDR019C | 4.72 | 1.18E-6 | GCV1 | T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm |
YDR304C | 4.69 | 1.39E-6 | CPR5 | Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER |