Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YDR464W | 9.98 | 9.10E-24 | 3.15 | SPP41 | Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3 |
YIL118W | 6.83 | 4.12E-12 | 0.26 | RHO3 | Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p |
YGR119C | 6.57 | 2.48E-11 | 0.59 | NUP57 | FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p) |
YDR167W | 5.98 | 1.11E-9 | 0.30 | TAF10 | Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification |
YKL153W_d | 5.68 | 6.66E-9 | 0.02 | YKL153W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant |
YDL212W | 5.67 | 7.32E-9 | 0.28 | SHR3 | Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface |
YGR074W | 5.39 | 3.62E-8 | 0.26 | SMD1 | Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1; protein abundance increases in response to DNA replication stress |
YLR276C | 5.13 | 1.47E-7 | 0.10 | DBP9 | DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain |
YPR169W | 5.02 | 2.56E-7 | 0.12 | JIP5 | Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein |
YDR526C_d | 4.91 | 4.64E-7 | 0.22 | YDR526C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YPR186C | 4.68 | 1.41E-6 | 0.21 | PZF1 | Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA |
YBR234C | 4.47 | 3.87E-6 | 0.05 | ARC40 | Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches |
YGL169W | 4.43 | 4.78E-6 | 0.29 | SUA5 | Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family |
YKR083C | 4.14 | 1.73E-5 | 0.11 | DAD2 | Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis |
YJR022W | 4.03 | 2.77E-5 | 0.01 | LSM8 | Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA |