Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YLR033W | 18.20 | 2.23E-74 | 3.77 | RSC58 | Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance |
YPL242C | 16.70 | 4.97E-63 | 3.77 | IQG1 | Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress |
YNR016C | 12.90 | 1.22E-38 | 1.31 | ACC1 | Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids; |
YBR091C | 11.60 | 1.35E-31 | 0.91 | TIM12 | Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins |
YIL126W | 10.70 | 3.95E-27 | 0.20 | STH1 | ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p |
YMR268C | 10.50 | 3.28E-26 | 0.61 | PRP24 | Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling |
YKL182W | 9.91 | 1.81E-23 | 0.03 | FAS1 | Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities |
YDR172W | 9.88 | 2.48E-23 | 1.02 | SUP35 | Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype |
YGL093W | 8.86 | 4.07E-19 | 0.09 | SPC105 | Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components |
YIR011C | 8.77 | 9.08E-19 | 0.35 | STS1 | Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation |
YOR116C | 8.42 | 1.87E-17 | 0.13 | RPO31 | RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 |
YLR424W | 8.29 | 5.71E-17 | 0.14 | SPP382 | Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation |
YFR037C | 8.15 | 1.82E-16 | 0.20 | RSC8 | Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters |
YCL004W | 7.95 | 8.96E-16 | 0.77 | PGS1 | Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis |
YBL026W | 7.18 | 3.41E-13 | 0.28 | LSM2 | Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress |