3761-0006

4-methylsulfanyl-3-quinolin-2-ylquinoline

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1138
Screen concentration 1.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 12061087
SMILES CSC1=C(C=NC2=CC=CC=C21)C3=NC4=CC=CC=C4C=C3
Standardized SMILES CSc1c(cnc2ccccc12)c3ccc4ccccc4n3
Molecular weight 302.3929
ALogP 4.69
H-bond donor count 0
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.57
% growth inhibition (Hom. pool) 1.23


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 12061087
Download HIP data (tab-delimited text)  (excel)
Gene:FAP7(YDL166C)|FD-Score:-3.37|P-value:3.71E-4|Clearance:0||SGD DESC:Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D Gene:HEM12(YDR047W)|FD-Score:3.1|P-value:9.66E-4|Clearance:0.48||SGD DESC:Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda Gene:SEC18(YBR080C)|FD-Score:4.54|P-value:2.80E-6|Clearance:1.08||SGD DESC:ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF Gene:SLD7(YOR060C)|FD-Score:4.19|P-value:1.42E-5|Clearance:1.08||SGD DESC:Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria Gene:TAH11(YJR046W)|FD-Score:-3.16|P-value:7.94E-4|Clearance:0||SGD DESC:DNA replication licensing factor, required for pre-replication complex assembly Gene:TTI1(YKL033W)|FD-Score:-3.36|P-value:3.83E-4|Clearance:0||SGD DESC:Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies Gene:FAP7(YDL166C)|FD-Score:-3.37|P-value:3.71E-4|Clearance:0||SGD DESC:Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D Gene:HEM12(YDR047W)|FD-Score:3.1|P-value:9.66E-4|Clearance:0.48||SGD DESC:Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda Gene:SEC18(YBR080C)|FD-Score:4.54|P-value:2.80E-6|Clearance:1.08||SGD DESC:ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF Gene:SLD7(YOR060C)|FD-Score:4.19|P-value:1.42E-5|Clearance:1.08||SGD DESC:Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria Gene:TAH11(YJR046W)|FD-Score:-3.16|P-value:7.94E-4|Clearance:0||SGD DESC:DNA replication licensing factor, required for pre-replication complex assembly Gene:TTI1(YKL033W)|FD-Score:-3.36|P-value:3.83E-4|Clearance:0||SGD DESC:Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 12061087
Download HOP data (tab-delimited text)  (excel)
Gene:ATG19(YOL082W)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles Gene:BCK2(YER167W)|FD-Score:3.76|P-value:8.65E-5||SGD DESC:Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations Gene:BUD32(YGR262C)|FD-Score:-5.38|P-value:3.67E-8||SGD DESC:Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription Gene:CSH1(YBR161W)|FD-Score:3.32|P-value:4.48E-4||SGD DESC:Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication Gene:ECM2(YBR065C)|FD-Score:3.15|P-value:8.29E-4||SGD DESC:Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p Gene:HRQ1(YDR291W_p)|FD-Score:3.17|P-value:7.61E-4||SGD DESC:3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS) Gene:MAC1(YMR021C)|FD-Score:-3.32|P-value:4.51E-4||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MRPS16(YPL013C)|FD-Score:3.32|P-value:4.55E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MTM1(YGR257C)|FD-Score:3.17|P-value:7.68E-4||SGD DESC:Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor Gene:NMA1(YLR328W)|FD-Score:-3.22|P-value:6.30E-4||SGD DESC:Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication Gene:PAT1(YCR077C)|FD-Score:-3.14|P-value:8.41E-4||SGD DESC:Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress Gene:PHO3(YBR092C)|FD-Score:3.41|P-value:3.21E-4||SGD DESC:Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin Gene:PPN1(YDR452W)|FD-Score:-3.11|P-value:9.28E-4||SGD DESC:Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress Gene:PUT3(YKL015W)|FD-Score:4.4|P-value:5.48E-6||SGD DESC:Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences as a dimer and undergoes a conformational change to form the active state; differentially phosphorylated in the presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain Gene:RAD54(YGL163C)|FD-Score:-4.35|P-value:6.90E-6||SGD DESC:DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress Gene:RPL17B(YJL177W)|FD-Score:3.38|P-value:3.67E-4||SGD DESC:Ribosomal 60S subunit protein L17B; homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17B has a paralog, RPL17A, that arose from the whole genome duplication Gene:RQC1(YDR333C_p)|FD-Score:3.43|P-value:3.00E-4||SGD DESC:Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC Gene:SNF6(YHL025W)|FD-Score:-5.28|P-value:6.37E-8||SGD DESC:Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions Gene:SVS1(YPL163C)|FD-Score:3.2|P-value:6.85E-4||SGD DESC:Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication Gene:TAL1(YLR354C)|FD-Score:-3.55|P-value:1.95E-4||SGD DESC:Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate Gene:TIM8(YJR135W-A)|FD-Score:3.75|P-value:8.72E-5||SGD DESC:Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome Gene:TIR2(YOR010C)|FD-Score:3.72|P-value:9.84E-5||SGD DESC:Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis Gene:TRX2(YGR209C)|FD-Score:3.09|P-value:9.87E-4||SGD DESC:Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress Gene:VPS21(YOR089C)|FD-Score:-5.73|P-value:4.94E-9||SGD DESC:Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication Gene:VPS9(YML097C)|FD-Score:3.69|P-value:1.12E-4||SGD DESC:A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin Gene:YBL096C(YBL096C_d)|FD-Score:3.43|P-value:3.04E-4||SGD DESC:Non-essential protein of unknown function Gene:YBR225W(YBR225W_p)|FD-Score:3.29|P-value:4.96E-4||SGD DESC:Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components Gene:YDR290W(YDR290W_d)|FD-Score:3.85|P-value:5.94E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103 Gene:YGL081W(YGL081W_p)|FD-Score:3.31|P-value:4.71E-4||SGD DESC:Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis Gene:YGR122W(YGR122W)|FD-Score:3.75|P-value:8.86E-5||SGD DESC:Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress Gene:YIL100W(YIL100W_d)|FD-Score:-3.3|P-value:4.88E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A Gene:YJL118W(YJL118W)|FD-Score:3.19|P-value:7.05E-4||SGD DESC:Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein Gene:YKL023W(YKL023W_p)|FD-Score:4.36|P-value:6.51E-6||SGD DESC:Putative protein of unknown function, predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YML082W(YML082W_p)|FD-Score:-4.02|P-value:2.95E-5||SGD DESC:Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene Gene:YML100W-A(YML100W-A_p)|FD-Score:3.38|P-value:3.56E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YMR010W(YMR010W_p)|FD-Score:3.59|P-value:1.68E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1 Gene:YNL195C(YNL195C_p)|FD-Score:-3.41|P-value:3.30E-4||SGD DESC:Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YOR333C(YOR333C_d)|FD-Score:3.98|P-value:3.48E-5||SGD DESC:Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth Gene:YPL245W(YPL245W_p)|FD-Score:3.52|P-value:2.13E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm Gene:ATG19(YOL082W)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles Gene:BCK2(YER167W)|FD-Score:3.76|P-value:8.65E-5||SGD DESC:Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations Gene:BUD32(YGR262C)|FD-Score:-5.38|P-value:3.67E-8||SGD DESC:Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription Gene:CSH1(YBR161W)|FD-Score:3.32|P-value:4.48E-4||SGD DESC:Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication Gene:ECM2(YBR065C)|FD-Score:3.15|P-value:8.29E-4||SGD DESC:Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p Gene:HRQ1(YDR291W_p)|FD-Score:3.17|P-value:7.61E-4||SGD DESC:3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS) Gene:MAC1(YMR021C)|FD-Score:-3.32|P-value:4.51E-4||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MRPS16(YPL013C)|FD-Score:3.32|P-value:4.55E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MTM1(YGR257C)|FD-Score:3.17|P-value:7.68E-4||SGD DESC:Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor Gene:NMA1(YLR328W)|FD-Score:-3.22|P-value:6.30E-4||SGD DESC:Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication Gene:PAT1(YCR077C)|FD-Score:-3.14|P-value:8.41E-4||SGD DESC:Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress Gene:PHO3(YBR092C)|FD-Score:3.41|P-value:3.21E-4||SGD DESC:Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin Gene:PPN1(YDR452W)|FD-Score:-3.11|P-value:9.28E-4||SGD DESC:Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress Gene:PUT3(YKL015W)|FD-Score:4.4|P-value:5.48E-6||SGD DESC:Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences as a dimer and undergoes a conformational change to form the active state; differentially phosphorylated in the presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain Gene:RAD54(YGL163C)|FD-Score:-4.35|P-value:6.90E-6||SGD DESC:DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress Gene:RPL17B(YJL177W)|FD-Score:3.38|P-value:3.67E-4||SGD DESC:Ribosomal 60S subunit protein L17B; homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17B has a paralog, RPL17A, that arose from the whole genome duplication Gene:RQC1(YDR333C_p)|FD-Score:3.43|P-value:3.00E-4||SGD DESC:Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC Gene:SNF6(YHL025W)|FD-Score:-5.28|P-value:6.37E-8||SGD DESC:Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions Gene:SVS1(YPL163C)|FD-Score:3.2|P-value:6.85E-4||SGD DESC:Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication Gene:TAL1(YLR354C)|FD-Score:-3.55|P-value:1.95E-4||SGD DESC:Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate Gene:TIM8(YJR135W-A)|FD-Score:3.75|P-value:8.72E-5||SGD DESC:Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome Gene:TIR2(YOR010C)|FD-Score:3.72|P-value:9.84E-5||SGD DESC:Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis Gene:TRX2(YGR209C)|FD-Score:3.09|P-value:9.87E-4||SGD DESC:Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress Gene:VPS21(YOR089C)|FD-Score:-5.73|P-value:4.94E-9||SGD DESC:Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication Gene:VPS9(YML097C)|FD-Score:3.69|P-value:1.12E-4||SGD DESC:A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin Gene:YBL096C(YBL096C_d)|FD-Score:3.43|P-value:3.04E-4||SGD DESC:Non-essential protein of unknown function Gene:YBR225W(YBR225W_p)|FD-Score:3.29|P-value:4.96E-4||SGD DESC:Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components Gene:YDR290W(YDR290W_d)|FD-Score:3.85|P-value:5.94E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103 Gene:YGL081W(YGL081W_p)|FD-Score:3.31|P-value:4.71E-4||SGD DESC:Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis Gene:YGR122W(YGR122W)|FD-Score:3.75|P-value:8.86E-5||SGD DESC:Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress Gene:YIL100W(YIL100W_d)|FD-Score:-3.3|P-value:4.88E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A Gene:YJL118W(YJL118W)|FD-Score:3.19|P-value:7.05E-4||SGD DESC:Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein Gene:YKL023W(YKL023W_p)|FD-Score:4.36|P-value:6.51E-6||SGD DESC:Putative protein of unknown function, predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YML082W(YML082W_p)|FD-Score:-4.02|P-value:2.95E-5||SGD DESC:Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene Gene:YML100W-A(YML100W-A_p)|FD-Score:3.38|P-value:3.56E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YMR010W(YMR010W_p)|FD-Score:3.59|P-value:1.68E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1 Gene:YNL195C(YNL195C_p)|FD-Score:-3.41|P-value:3.30E-4||SGD DESC:Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YOR333C(YOR333C_d)|FD-Score:3.98|P-value:3.48E-5||SGD DESC:Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth Gene:YPL245W(YPL245W_p)|FD-Score:3.52|P-value:2.13E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YBR080C4.542.80E-61.08SEC18ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF
YOR060C4.191.42E-51.08SLD7Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria
YDR047W3.109.66E-40.48HEM12Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
YIL063C2.620.004350.08YRB2Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential
YHR088W2.540.005480.06RPF1Nucleolar protein involved in the assembly and export of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA
YNL182C2.480.006540.00IPI3Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene
YDR398W2.480.006590.04UTP5Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
YAR019C2.440.007280.07CDC15Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress
YGL099W2.370.008850.07LSG1Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
YOL120C2.300.010600.04RPL18ARibosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
YKL060C2.260.011800.01FBA1Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress
YJR002W2.260.012000.01MPP10Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p
YHR042W2.240.012400.01NCP1NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
YKL141W2.240.012700.00SDH3Subunit of both succinate dehydrogenase and of TIM22 translocase; functions as the cytochrome b subunit of succinate dehydrogenase, which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex
YDR487C2.230.012800.01RIB33,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YKL015W4.405.48E-6PUT3Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences as a dimer and undergoes a conformational change to form the active state; differentially phosphorylated in the presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain
YKL023W_p4.366.51E-6YKL023W_pPutative protein of unknown function, predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YOR333C_d3.983.48E-5YOR333C_dDubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth
YDR290W_d3.855.94E-5YDR290W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103
YER167W3.768.65E-5BCK2Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations
YJR135W-A3.758.72E-5TIM8Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome
YGR122W3.758.86E-5YGR122WProtein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
YOR010C3.729.84E-5TIR2Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
YML097C3.691.12E-4VPS9A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
YMR010W_p3.591.68E-4YMR010W_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1
YPL245W_p3.522.13E-4YPL245W_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YDR333C_p3.433.00E-4RQC1_pComponent of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC
YBL096C_d3.433.04E-4YBL096C_dNon-essential protein of unknown function
YBR092C3.413.21E-4PHO3Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
YOL082W3.413.24E-4ATG19Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles

GO enrichment analysis for SGTC_1138
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0984.72E-14SGTC_12092323-2347 50.3 μMChemDiv (Drug-like library)54127600.135135
0.0952.09E-13SGTC_11921488-0095 21.4 μMChemDiv (Drug-like library)9158750.142857
0.0765.72E-9SGTC_12660828-0227 32.9 μMChemDiv (Drug-like library)39138200.1
0.0766.21E-9SGTC_11483909-7663 27.7 μMChemDiv (Drug-like library)40845260.220339
0.0741.57E-8SGTC_11861319-0216 26.0 μMChemDiv (Drug-like library)45651360.126582
0.0714.81E-8SGTC_32269131256 49.5 μMChembridge (Drug-like library)171780730.0487805
0.0708.21E-8SGTC_2605digitonin 300.0 nMTimTec (Pure natural product library)27350100.00833333
0.0708.50E-8SGTC_273hydroxyurea 18.1 mMMiscellaneous3657NAheme biosynthesis & mitochondrial translocase
0.0672.29E-7SGTC_13581509-0022 2.5 μMChemDiv (Drug-like library)32584340.0461538
0.0672.89E-7SGTC_9322857-0803 154.0 μMChemDiv (Drug-like library)6748980.0634921
0.0663.50E-7SGTC_11403229-1848 3.0 μMChemDiv (Drug-like library)28495250.046875
0.0648.02E-7SGTC_12710832-2808 169.0 μMChemDiv (Drug-like library)36637940.0645161
0.0649.39E-7SGTC_32309131665 49.5 μMChembridge (Drug-like library)159437200.0625
0.0631.43E-6SGTC_11433454-2408 5.1 μMChemDiv (Drug-like library)X11430.10810860S ribosome export
0.0622.12E-6SGTC_13171273-0028 910.0 nMChemDiv (Drug-like library)59178030.0655738azole & statin

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1705st02786856.33 μM0.465116292948TimTec (Natural product derivative library)256.301284.14902
SGTC_7070865-0008204 μM0.369565723043ChemDiv (Drug-like library)246.26343.89503DNA damage response
SGTC_2151556326785.42 μM0.35310824Chembridge (Fragment library)199.248422.68512
SGTC_6721441-001853.7 μM0.291667251141ChemDiv (Drug-like library)212.270323.19403
SGTC_11891431-21197.28 μM0.283107275ChemDiv (Drug-like library)254.714244.76912
SGTC_3119912518349.47 μM0.27777822695334Chembridge (Drug-like library)291.370224.38913
SGTC_10420350-009682 μM0.2692313122515ChemDiv (Drug-like library)372.41653.28825TSC3-RPN4
SGTC_1070358-00222.69 μM0.266667521106ChemDiv (Drug-like library)350.453965.87124SWF1 & branched chain AA biosynthesis
SGTC_9801473-0395201 μM0.263158768876ChemDiv (Drug-like library)278.305263.67504
SGTC_1930st07463434.3 μM0.259259684253TimTec (Natural product derivative library)245.275344.02302RNA pol III & RNase P/MRP