| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YPL069C | 7.26 | 1.98E-13 | BTS1 | Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic |
| YER028C | 6.64 | 1.52E-11 | MIG3 | Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication |
| YLR358C_p | 6.43 | 6.24E-11 | YLR358C_p | Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W |
| YLL010C | 6.40 | 7.85E-11 | PSR1 | Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p |
| YJL100W | 6.31 | 1.39E-10 | LSB6 | Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization |
| YLR354C | 6.25 | 2.08E-10 | TAL1 | Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate |
| YBR282W | 5.32 | 5.10E-8 | MRPL27 | Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP |
| YOR107W | 5.31 | 5.43E-8 | RGS2 | Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p |
| YBL042C | 5.11 | 1.61E-7 | FUI1 | High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress |
| YOR089C | 5.10 | 1.72E-7 | VPS21 | Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication |
| YLR292C | 5.01 | 2.65E-7 | SEC72 | Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER |
| YBR231C | 4.91 | 4.54E-7 | SWC5 | Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress |
| YGR236C | 4.76 | 9.60E-7 | SPG1 | Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| YHR009C_p | 4.73 | 1.15E-6 | TDA3_p | Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1 |
| YLR110C | 4.53 | 2.97E-6 | CCW12 | Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication |
