Deletion Strain | FD score | P-value | Gene | Gene Description |
---|
YNL315C | 9.14 | 3.15E-20 | ATP11 | Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase |
YJR121W | 6.22 | 2.53E-10 | ATP2 | Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated |
YOR027W | 6.17 | 3.48E-10 | STI1 | Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop |
YPL127C | 6.01 | 9.33E-10 | HHO1 | Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination |
YFL016C | 5.48 | 2.15E-8 | MDJ1 | Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones |
YJL094C | 5.16 | 1.22E-7 | KHA1 | Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies |
YMR188C | 5.10 | 1.71E-7 | MRPS17 | Mitochondrial ribosomal protein of the small subunit |
YJL205C | 4.91 | 4.45E-7 | NCE101 | Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences |
YDR125C | 4.82 | 7.36E-7 | ECM18 | Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication |
YER139C | 4.71 | 1.24E-6 | RTR1 | CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication |
YMR062C | 4.54 | 2.77E-6 | ARG7 | Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine |
YOL136C | 4.42 | 5.04E-6 | PFK27 | 6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A |
YNL100W | 4.33 | 7.50E-6 | AIM37 | Mitochondrial inner membrane protein; component of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture |
YLR372W | 4.31 | 8.04E-6 | SUR4 | Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis |
YGL060W | 4.23 | 1.16E-5 | YBP2 | Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication |