Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YHR007C | 4.62 | 1.93E-6 | 0.72 | ERG11 | Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p |
YKL195W | 4.58 | 2.36E-6 | 0.72 | MIA40 | Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p |
YNL232W | 3.86 | 5.71E-5 | 0.08 | CSL4 | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1) |
YJL011C | 3.78 | 7.84E-5 | 0.06 | RPC17 | RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress |
YHR068W | 3.72 | 1.01E-4 | 0.14 | DYS1 | Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric |
YOR074C | 3.57 | 1.77E-4 | 0.08 | CDC21 | Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S |
YER127W | 3.49 | 2.39E-4 | 0.03 | LCP5 | Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus |
YNR053C | 3.46 | 2.72E-4 | 0.14 | NOG2 | Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation |
YKL036C_d | 3.31 | 4.60E-4 | 0.02 | YKL036C_d | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W |
YJL014W | 3.29 | 4.99E-4 | 0.07 | CCT3 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
YFR002W | 3.22 | 6.42E-4 | 0.02 | NIC96 | Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p) |
YOL144W | 3.20 | 6.85E-4 | 0.07 | NOP8 | Nucleolar protein required for 60S ribosomal subunit biogenesis |
YBR140C | 3.13 | 8.73E-4 | 0.01 | IRA1 | GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication |
YJR093C | 3.12 | 8.95E-4 | 0.01 | FIP1 | Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p |
YML091C | 3.12 | 9.17E-4 | 0.04 | RPM2 | Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus |