Deletion Strain | FD score | P-value | Gene | Gene Description |
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YKL211C | 12.60 | 7.22E-37 | TRP3 | Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p |
YER090W | 10.10 | 3.71E-24 | TRP2 | Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p |
YDR007W | 7.65 | 1.04E-14 | TRP1 | Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) |
YDR354W | 7.01 | 1.21E-12 | TRP4 | Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis |
YLR354C | 5.94 | 1.46E-9 | TAL1 | Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate |
YEL061C | 5.57 | 1.28E-8 | CIN8 | Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation |
YGL186C | 5.52 | 1.65E-8 | TPN1 | Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p |
YGL100W | 5.33 | 4.79E-8 | SEH1 | Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1 |
YOR132W | 5.12 | 1.54E-7 | VPS17 | Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes |
YKL023W_p | 5.07 | 1.98E-7 | YKL023W_p | Putative protein of unknown function, predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |
YGL148W | 5.03 | 2.50E-7 | ARO2 | Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress |
YLR330W | 4.79 | 8.16E-7 | CHS5 | Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane |
YDR003W-A_p | 4.78 | 8.60E-7 | YDR003W-A_p | Putative protein of unknown function; identified by expression profiling and mass spectrometry |
YLR455W_p | 4.76 | 9.92E-7 | YLR455W_p | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); protein abundance increases in response to DNA replication stress |
YDL118W_p | 4.61 | 2.05E-6 | YDL118W_p | Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein |