Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
---|
YGR265W_d | 5.72 | 5.26E-9 | 1.58 | YGR265W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase |
YOR257W | 4.14 | 1.72E-5 | 0.02 | CDC31 | Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation |
YBR123C | 4.12 | 1.90E-5 | 0.08 | TFC1 | One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63 |
YHR023W | 4.04 | 2.66E-5 | 0.09 | MYO1 | Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively |
YOR210W | 3.95 | 3.92E-5 | 0.19 | RPB10 | RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III |
YBR257W | 3.76 | 8.59E-5 | 0.23 | POP4 | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P |
YDL014W | 3.52 | 2.14E-4 | 0.01 | NOP1 | Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin |
YHL015W | 3.51 | 2.20E-4 | 0.27 | RPS20 | Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10 |
YGR175C | 3.24 | 5.89E-4 | 0.15 | ERG1 | Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine |
YNL114C_d | 3.09 | 9.98E-4 | 0.15 | YNL114C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit |
YDR177W | 2.94 | 0.00166 | 0.02 | UBC1 | Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress |
YDR365C | 2.92 | 0.00178 | 0.01 | ESF1 | Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels |
YFR002W | 2.91 | 0.00181 | 0.03 | NIC96 | Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p) |
YNL061W | 2.88 | 0.00199 | 0.02 | NOP2 | Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles |
YPL131W | 2.86 | 0.00210 | 0.02 | RPL5 | Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly |