Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YPR178W | 4.19 | 1.42E-5 | 0.68 | PRP4 | Splicing factor, component of the U4/U6-U5 snRNP complex |
YGL001C | 3.50 | 2.30E-4 | 0.23 | ERG26 | C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis |
YFR027W | 3.28 | 5.24E-4 | 0.02 | ECO1 | Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress |
YHR007C | 3.25 | 5.72E-4 | 0.01 | ERG11 | Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p |
YGR094W | 3.25 | 5.86E-4 | 0.19 | VAS1 | Mitochondrial and cytoplasmic valyl-tRNA synthetase |
YLR272C | 3.05 | 0.00113 | 2.63E-4 | YCS4 | Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation |
YNL306W | 3.05 | 0.00113 | 0.05 | MRPS18 | Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins |
YGR119C | 3.01 | 0.00133 | 0.05 | NUP57 | FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p) |
YOR210W | 2.95 | 0.00159 | 0.06 | RPB10 | RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III |
YLR212C | 2.89 | 0.00191 | 0.09 | TUB4 | Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress |
YOR149C | 2.81 | 0.00251 | 0.02 | SMP3 | Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure |
YKL049C | 2.78 | 0.00270 | 0.06 | CSE4 | Centromere protein that resembles histone H3; required for proper kinetochore function; homolog of human CENP-A; levels are regulated by E3 ubiquitin ligase Psh1p; Cse4p marks a subset of open chromatin; associated with promoters, accessible chromatin and RNA polymerase II-bound regions |
YDR023W | 2.73 | 0.00320 | 0.05 | SES1 | Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p |
YPL175W | 2.68 | 0.00369 | 0.01 | SPT14 | UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins |
YNL261W | 2.67 | 0.00380 | 0.02 | ORC5 | Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing |