Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YLR033W | 6.48 | 4.48E-11 | 0.75 | RSC58 | Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance |
YBL105C | 5.73 | 4.99E-9 | 6.33E-4 | PKC1 | Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) |
YGR114C_d | 5.73 | 5.00E-9 | 0.17 | YGR114C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6 |
YBR192W | 5.56 | 1.36E-8 | 0.04 | RIM2 | Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family |
YJL014W | 5.51 | 1.75E-8 | 0.40 | CCT3 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
YFR037C | 5.11 | 1.60E-7 | 0.59 | RSC8 | Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters |
YDL196W_d | 4.52 | 3.11E-6 | 0.25 | YDL196W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 |
YDR141C | 4.27 | 9.63E-6 | 0.14 | DOP1 | Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies |
YCR052W | 4.13 | 1.82E-5 | 0.16 | RSC6 | Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p |
YMR168C | 3.97 | 3.62E-5 | 0.09 | CEP3 | Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain |
YLR321C | 3.88 | 5.22E-5 | 0.08 | SFH1 | Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog |
YOR370C | 3.80 | 7.31E-5 | 0.02 | MRS6 | Rab escort protein; forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene; relative distribution to the nucleus increases upon DNA replication stress |
YGL137W | 3.78 | 7.85E-5 | 0.08 | SEC27 | Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP |
YIR011C | 3.70 | 1.06E-4 | 0.19 | STS1 | Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation |
YPR107C | 3.52 | 2.19E-4 | 0.02 | YTH1 | Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation |