Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YDR168W | 5.26 | 7.39E-8 | 0.64 | CDC37 | Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding |
YBL105C | 4.86 | 5.82E-7 | 0.64 | PKC1 | Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) |
YDR404C | 4.84 | 6.65E-7 | 0.64 | RPB7 | RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation |
YCR052W | 4.48 | 3.78E-6 | 0.64 | RSC6 | Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p |
YGR029W | 3.84 | 6.24E-5 | 0.07 | ERV1 | Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR) |
YDR188W | 3.76 | 8.44E-5 | 0.10 | CCT6 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif |
YHR019C | 3.66 | 1.25E-4 | 0.05 | DED81 | Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA |
YDL147W | 3.61 | 1.54E-4 | 0.21 | RPN5 | Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein |
YBR087W | 3.40 | 3.41E-4 | 0.06 | RFC5 | Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon |
YMR033W | 3.34 | 4.21E-4 | 0.03 | ARP9 | Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation |
YJL009W_d | 3.31 | 4.64E-4 | 0.00 | YJL009W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex |
YIL126W | 3.31 | 4.66E-4 | 0.07 | STH1 | ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p |
YLR167W | 3.24 | 5.97E-4 | 0.10 | RPS31 | Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog |
YNL131W | 3.14 | 8.40E-4 | 0.08 | TOM22 | Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes |
YFL039C | 3.06 | 0.00111 | 0.04 | ACT1 | Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions |