0848-0131

2-[(2-oxonaphthalen-1-ylidene)methylamino]-4,5-diphenylfuran-3-carbonitrile

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1176
Screen concentration 83.3 μM
Source ChemDiv (Drug-like library)
PubChem CID 6769040
SMILES C1=CC=C(C=C1)C2=C(OC(=C2C#N)NC=C3C(=O)C=CC4=CC=CC=C43)C5=CC=CC=C5
Standardized SMILES Oc1ccc2ccccc2c1C=Nc3oc(c4ccccc4)c(c5ccccc5)c3C#N
Molecular weight 414.4547
ALogP 5.59
H-bond donor count 1
H-bond acceptor count 4
Response signature Golgi

Pool Growth Kinetics
% growth inhibition (Het. pool) 9.7
% growth inhibition (Hom. pool) 9.62


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 6769040
Download HIP data (tab-delimited text)  (excel)
Gene:CCT6(YDR188W)|FD-Score:-3.93|P-value:4.25E-5|Clearance:0||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif Gene:CDC33(YOL139C)|FD-Score:3.46|P-value:2.72E-4|Clearance:0.08||SGD DESC:mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth Gene:ECO1(YFR027W)|FD-Score:4.56|P-value:2.58E-6|Clearance:0.77||SGD DESC:Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress Gene:ERB1(YMR049C)|FD-Score:-3.87|P-value:5.48E-5|Clearance:0||SGD DESC:Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1 Gene:GPI18(YBR004C)|FD-Score:3.17|P-value:7.61E-4|Clearance:0.2||SGD DESC:Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria Gene:GRC3(YLL035W)|FD-Score:4.6|P-value:2.08E-6|Clearance:0.77||SGD DESC:Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated Gene:ILV3(YJR016C)|FD-Score:3.24|P-value:6.00E-4|Clearance:0.07||SGD DESC:Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids Gene:NAM9(YNL137C)|FD-Score:3.35|P-value:4.00E-4|Clearance:0.11||SGD DESC:Mitochondrial ribosomal component of the small subunit Gene:PCF11(YDR228C)|FD-Score:3.6|P-value:1.56E-4|Clearance:0.03||SGD DESC:mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping Gene:POP1(YNL221C)|FD-Score:4.37|P-value:6.14E-6|Clearance:0.77||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P Gene:SMD2(YLR275W)|FD-Score:3.38|P-value:3.68E-4|Clearance:0.02||SGD DESC:Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2 Gene:TIF35(YDR429C)|FD-Score:3.57|P-value:1.77E-4|Clearance:0.11||SGD DESC:eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation Gene:CCT6(YDR188W)|FD-Score:-3.93|P-value:4.25E-5|Clearance:0||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif Gene:CDC33(YOL139C)|FD-Score:3.46|P-value:2.72E-4|Clearance:0.08||SGD DESC:mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth Gene:ECO1(YFR027W)|FD-Score:4.56|P-value:2.58E-6|Clearance:0.77||SGD DESC:Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress Gene:ERB1(YMR049C)|FD-Score:-3.87|P-value:5.48E-5|Clearance:0||SGD DESC:Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1 Gene:GPI18(YBR004C)|FD-Score:3.17|P-value:7.61E-4|Clearance:0.2||SGD DESC:Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria Gene:GRC3(YLL035W)|FD-Score:4.6|P-value:2.08E-6|Clearance:0.77||SGD DESC:Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated Gene:ILV3(YJR016C)|FD-Score:3.24|P-value:6.00E-4|Clearance:0.07||SGD DESC:Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids Gene:NAM9(YNL137C)|FD-Score:3.35|P-value:4.00E-4|Clearance:0.11||SGD DESC:Mitochondrial ribosomal component of the small subunit Gene:PCF11(YDR228C)|FD-Score:3.6|P-value:1.56E-4|Clearance:0.03||SGD DESC:mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping Gene:POP1(YNL221C)|FD-Score:4.37|P-value:6.14E-6|Clearance:0.77||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P Gene:SMD2(YLR275W)|FD-Score:3.38|P-value:3.68E-4|Clearance:0.02||SGD DESC:Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2 Gene:TIF35(YDR429C)|FD-Score:3.57|P-value:1.77E-4|Clearance:0.11||SGD DESC:eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 6769040
Download HOP data (tab-delimited text)  (excel)
Gene:ADD37(YMR184W)|FD-Score:3.95|P-value:3.94E-5||SGD DESC:Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress Gene:ADE4(YMR300C)|FD-Score:4.91|P-value:4.52E-7||SGD DESC:Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway Gene:ARE2(YNR019W)|FD-Score:3.47|P-value:2.60E-4||SGD DESC:Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication Gene:ARL1(YBR164C)|FD-Score:3.84|P-value:6.12E-5||SGD DESC:Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor Gene:BAT2(YJR148W)|FD-Score:-3.15|P-value:8.13E-4||SGD DESC:Cytosolic branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase Gene:CDA2(YLR308W)|FD-Score:3.92|P-value:4.34E-5||SGD DESC:Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall Gene:CIN2(YPL241C)|FD-Score:3.13|P-value:8.81E-4||SGD DESC:GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2 Gene:COA4(YLR218C)|FD-Score:3.18|P-value:7.31E-4||SGD DESC:Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors Gene:COG5(YNL051W)|FD-Score:5.88|P-value:2.07E-9||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG8(YML071C)|FD-Score:5.05|P-value:2.16E-7||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CUS2(YNL286W)|FD-Score:3.42|P-value:3.12E-4||SGD DESC:Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs) Gene:CYC7(YEL039C)|FD-Score:4.14|P-value:1.77E-5||SGD DESC:Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication Gene:DNL4(YOR005C)|FD-Score:3.84|P-value:6.09E-5||SGD DESC:DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth Gene:ENV7(YPL236C)|FD-Score:3.21|P-value:6.62E-4||SGD DESC:Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16) Gene:HIR3(YJR140C)|FD-Score:4.47|P-value:3.82E-6||SGD DESC:Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein Gene:HOR2(YER062C)|FD-Score:5.92|P-value:1.60E-9||SGD DESC:Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication Gene:HUT1(YPL244C)|FD-Score:3.16|P-value:7.98E-4||SGD DESC:Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1 Gene:LAP2(YNL045W)|FD-Score:4.45|P-value:4.30E-6||SGD DESC:Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus Gene:MMS4(YBR098W)|FD-Score:3.83|P-value:6.28E-5||SGD DESC:Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p Gene:MRPL39(YML009C)|FD-Score:3.12|P-value:8.98E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL49(YJL096W)|FD-Score:-3.53|P-value:2.06E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPS8(YMR158W)|FD-Score:4.35|P-value:6.84E-6||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:NNT1(YLR285W)|FD-Score:4.65|P-value:1.68E-6||SGD DESC:S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination Gene:OCA5(YHL029C_p)|FD-Score:3.16|P-value:7.87E-4||SGD DESC:Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts Gene:PBS2(YJL128C)|FD-Score:5.15|P-value:1.28E-7||SGD DESC:MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition Gene:PER1(YCR044C)|FD-Score:4.54|P-value:2.79E-6||SGD DESC:Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1 Gene:PUF3(YLL013C)|FD-Score:-3.27|P-value:5.35E-4||SGD DESC:Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins Gene:RBK1(YCR036W)|FD-Score:5.3|P-value:5.76E-8||SGD DESC:Putative ribokinase Gene:RCE1(YMR274C)|FD-Score:4.23|P-value:1.16E-5||SGD DESC:Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone Gene:RPL26B(YGR034W)|FD-Score:-3.21|P-value:6.66E-4||SGD DESC:Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication Gene:RPL8B(YLL045C)|FD-Score:3.49|P-value:2.41E-4||SGD DESC:Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication Gene:RPN13(YLR421C)|FD-Score:-3.71|P-value:1.02E-4||SGD DESC:Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress Gene:RUD3(YOR216C)|FD-Score:3.31|P-value:4.61E-4||SGD DESC:Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1 Gene:SCW11(YGL028C)|FD-Score:-3.65|P-value:1.29E-4||SGD DESC:Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p Gene:SHE3(YBR130C)|FD-Score:3.56|P-value:1.82E-4||SGD DESC:Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance Gene:SIP3(YNL257C)|FD-Score:-3.54|P-value:2.03E-4||SGD DESC:Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication Gene:SIT4(YDL047W)|FD-Score:4.92|P-value:4.28E-7||SGD DESC:Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization Gene:SLX1(YBR228W)|FD-Score:-3.3|P-value:4.77E-4||SGD DESC:Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p Gene:SNO1(YMR095C)|FD-Score:4.32|P-value:7.96E-6||SGD DESC:Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase Gene:SSP2(YOR242C)|FD-Score:3.09|P-value:9.95E-4||SGD DESC:Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis Gene:STM1(YLR150W)|FD-Score:3.35|P-value:4.02E-4||SGD DESC:Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery Gene:TAD1(YGL243W)|FD-Score:3.15|P-value:8.05E-4||SGD DESC:tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala Gene:TOK1(YJL093C)|FD-Score:3.16|P-value:7.91E-4||SGD DESC:Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin Gene:TSR2(YLR435W)|FD-Score:3.62|P-value:1.46E-4||SGD DESC:Protein with a potential role in pre-rRNA processing Gene:TSR3(YOR006C)|FD-Score:3.88|P-value:5.32E-5||SGD DESC:Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress Gene:UMP1(YBR173C)|FD-Score:3.23|P-value:6.23E-4||SGD DESC:Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly Gene:VIP1(YLR410W)|FD-Score:3.52|P-value:2.18E-4||SGD DESC:Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1 Gene:VPS63(YLR261C_d)|FD-Score:5.4|P-value:3.25E-8||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect Gene:YBR116C(YBR116C_d)|FD-Score:5.25|P-value:7.41E-8||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2 Gene:YCL001W-B(YCL001W-B_p)|FD-Score:-3.64|P-value:1.38E-4||SGD DESC:Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication Gene:YCR102C(YCR102C_p)|FD-Score:3.15|P-value:8.18E-4||SGD DESC:Putative protein of unknown function, involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family Gene:YDR433W(YDR433W_d)|FD-Score:3.87|P-value:5.45E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YER084W(YER084W_p)|FD-Score:4.02|P-value:2.94E-5||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YGL177W(YGL177W_d)|FD-Score:3.2|P-value:6.77E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YKL162C(YKL162C_p)|FD-Score:3.28|P-value:5.18E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion Gene:YKL222C(YKL222C)|FD-Score:3.65|P-value:1.29E-4||SGD DESC:Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine Gene:YML002W(YML002W_p)|FD-Score:4.56|P-value:2.51E-6||SGD DESC:Putative protein of unknown function; expression induced by heat and by calcium shortage Gene:YMR111C(YMR111C_p)|FD-Score:3.6|P-value:1.61E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress Gene:YNL146C-A(YNL146C-A_p)|FD-Score:3.11|P-value:9.41E-4||SGD DESC:Putative protein of unknown function Gene:YOR318C(YOR318C_d)|FD-Score:3.44|P-value:2.95E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo Gene:YRF1-6(YNL339C)|FD-Score:6.2|P-value:2.91E-10||SGD DESC:Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p Gene:ADD37(YMR184W)|FD-Score:3.95|P-value:3.94E-5||SGD DESC:Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress Gene:ADE4(YMR300C)|FD-Score:4.91|P-value:4.52E-7||SGD DESC:Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway Gene:ARE2(YNR019W)|FD-Score:3.47|P-value:2.60E-4||SGD DESC:Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication Gene:ARL1(YBR164C)|FD-Score:3.84|P-value:6.12E-5||SGD DESC:Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor Gene:BAT2(YJR148W)|FD-Score:-3.15|P-value:8.13E-4||SGD DESC:Cytosolic branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase Gene:CDA2(YLR308W)|FD-Score:3.92|P-value:4.34E-5||SGD DESC:Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall Gene:CIN2(YPL241C)|FD-Score:3.13|P-value:8.81E-4||SGD DESC:GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2 Gene:COA4(YLR218C)|FD-Score:3.18|P-value:7.31E-4||SGD DESC:Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors Gene:COG5(YNL051W)|FD-Score:5.88|P-value:2.07E-9||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG8(YML071C)|FD-Score:5.05|P-value:2.16E-7||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CUS2(YNL286W)|FD-Score:3.42|P-value:3.12E-4||SGD DESC:Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs) Gene:CYC7(YEL039C)|FD-Score:4.14|P-value:1.77E-5||SGD DESC:Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication Gene:DNL4(YOR005C)|FD-Score:3.84|P-value:6.09E-5||SGD DESC:DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth Gene:ENV7(YPL236C)|FD-Score:3.21|P-value:6.62E-4||SGD DESC:Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16) Gene:HIR3(YJR140C)|FD-Score:4.47|P-value:3.82E-6||SGD DESC:Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein Gene:HOR2(YER062C)|FD-Score:5.92|P-value:1.60E-9||SGD DESC:Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication Gene:HUT1(YPL244C)|FD-Score:3.16|P-value:7.98E-4||SGD DESC:Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1 Gene:LAP2(YNL045W)|FD-Score:4.45|P-value:4.30E-6||SGD DESC:Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus Gene:MMS4(YBR098W)|FD-Score:3.83|P-value:6.28E-5||SGD DESC:Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p Gene:MRPL39(YML009C)|FD-Score:3.12|P-value:8.98E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL49(YJL096W)|FD-Score:-3.53|P-value:2.06E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPS8(YMR158W)|FD-Score:4.35|P-value:6.84E-6||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:NNT1(YLR285W)|FD-Score:4.65|P-value:1.68E-6||SGD DESC:S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination Gene:OCA5(YHL029C_p)|FD-Score:3.16|P-value:7.87E-4||SGD DESC:Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts Gene:PBS2(YJL128C)|FD-Score:5.15|P-value:1.28E-7||SGD DESC:MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition Gene:PER1(YCR044C)|FD-Score:4.54|P-value:2.79E-6||SGD DESC:Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1 Gene:PUF3(YLL013C)|FD-Score:-3.27|P-value:5.35E-4||SGD DESC:Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins Gene:RBK1(YCR036W)|FD-Score:5.3|P-value:5.76E-8||SGD DESC:Putative ribokinase Gene:RCE1(YMR274C)|FD-Score:4.23|P-value:1.16E-5||SGD DESC:Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone Gene:RPL26B(YGR034W)|FD-Score:-3.21|P-value:6.66E-4||SGD DESC:Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication Gene:RPL8B(YLL045C)|FD-Score:3.49|P-value:2.41E-4||SGD DESC:Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication Gene:RPN13(YLR421C)|FD-Score:-3.71|P-value:1.02E-4||SGD DESC:Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress Gene:RUD3(YOR216C)|FD-Score:3.31|P-value:4.61E-4||SGD DESC:Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1 Gene:SCW11(YGL028C)|FD-Score:-3.65|P-value:1.29E-4||SGD DESC:Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p Gene:SHE3(YBR130C)|FD-Score:3.56|P-value:1.82E-4||SGD DESC:Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance Gene:SIP3(YNL257C)|FD-Score:-3.54|P-value:2.03E-4||SGD DESC:Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication Gene:SIT4(YDL047W)|FD-Score:4.92|P-value:4.28E-7||SGD DESC:Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization Gene:SLX1(YBR228W)|FD-Score:-3.3|P-value:4.77E-4||SGD DESC:Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p Gene:SNO1(YMR095C)|FD-Score:4.32|P-value:7.96E-6||SGD DESC:Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase Gene:SSP2(YOR242C)|FD-Score:3.09|P-value:9.95E-4||SGD DESC:Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis Gene:STM1(YLR150W)|FD-Score:3.35|P-value:4.02E-4||SGD DESC:Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery Gene:TAD1(YGL243W)|FD-Score:3.15|P-value:8.05E-4||SGD DESC:tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala Gene:TOK1(YJL093C)|FD-Score:3.16|P-value:7.91E-4||SGD DESC:Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin Gene:TSR2(YLR435W)|FD-Score:3.62|P-value:1.46E-4||SGD DESC:Protein with a potential role in pre-rRNA processing Gene:TSR3(YOR006C)|FD-Score:3.88|P-value:5.32E-5||SGD DESC:Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress Gene:UMP1(YBR173C)|FD-Score:3.23|P-value:6.23E-4||SGD DESC:Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly Gene:VIP1(YLR410W)|FD-Score:3.52|P-value:2.18E-4||SGD DESC:Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1 Gene:VPS63(YLR261C_d)|FD-Score:5.4|P-value:3.25E-8||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect Gene:YBR116C(YBR116C_d)|FD-Score:5.25|P-value:7.41E-8||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2 Gene:YCL001W-B(YCL001W-B_p)|FD-Score:-3.64|P-value:1.38E-4||SGD DESC:Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication Gene:YCR102C(YCR102C_p)|FD-Score:3.15|P-value:8.18E-4||SGD DESC:Putative protein of unknown function, involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family Gene:YDR433W(YDR433W_d)|FD-Score:3.87|P-value:5.45E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YER084W(YER084W_p)|FD-Score:4.02|P-value:2.94E-5||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YGL177W(YGL177W_d)|FD-Score:3.2|P-value:6.77E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YKL162C(YKL162C_p)|FD-Score:3.28|P-value:5.18E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion Gene:YKL222C(YKL222C)|FD-Score:3.65|P-value:1.29E-4||SGD DESC:Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine Gene:YML002W(YML002W_p)|FD-Score:4.56|P-value:2.51E-6||SGD DESC:Putative protein of unknown function; expression induced by heat and by calcium shortage Gene:YMR111C(YMR111C_p)|FD-Score:3.6|P-value:1.61E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress Gene:YNL146C-A(YNL146C-A_p)|FD-Score:3.11|P-value:9.41E-4||SGD DESC:Putative protein of unknown function Gene:YOR318C(YOR318C_d)|FD-Score:3.44|P-value:2.95E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo Gene:YRF1-6(YNL339C)|FD-Score:6.2|P-value:2.91E-10||SGD DESC:Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YLL035W4.602.08E-60.77GRC3Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated
YFR027W4.562.58E-60.77ECO1Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress
YNL221C4.376.14E-60.77POP1Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
YDR228C3.601.56E-40.03PCF11mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping
YDR429C3.571.77E-40.12TIF35eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation
YOL139C3.462.72E-40.08CDC33mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth
YLR275W3.383.68E-40.02SMD2Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2
YNL137C3.354.00E-40.11NAM9Mitochondrial ribosomal component of the small subunit
YJR016C3.246.00E-40.07ILV3Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
YBR004C3.177.61E-40.20GPI18Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria
YDL209C2.970.001471.49E-4CWC2Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2
YGL055W2.970.001470.05OLE1Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YNL290W2.930.001700.08RFC3Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YOR060C2.850.002220.01SLD7Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria
YER133W2.840.002290.09GLC7Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YNL339C6.202.91E-10YRF1-6Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
YER062C5.921.60E-9HOR2Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication
YNL051W5.882.07E-9COG5Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YLR261C_d5.403.25E-8VPS63_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect
YCR036W5.305.76E-8RBK1Putative ribokinase
YBR116C_d5.257.41E-8YBR116C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
YJL128C5.151.28E-7PBS2MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition
YML071C5.052.16E-7COG8Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YDL047W4.924.28E-7SIT4Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YMR300C4.914.52E-7ADE4Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway
YLR285W4.651.68E-6NNT1S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination
YML002W_p4.562.51E-6YML002W_pPutative protein of unknown function; expression induced by heat and by calcium shortage
YCR044C4.542.79E-6PER1Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1
YJR140C4.473.82E-6HIR3Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein
YNL045W4.454.30E-6LAP2Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus

GO enrichment analysis for SGTC_1176
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.0971.06E-13SGTC_13061185-0270 9.0 μMChemDiv (Drug-like library)15480760.114286Golgi
0.0921.45E-12SGTC_1162k048-0130 20.1 μMChemDiv (Drug-like library)67974060.212121Golgi
0.0896.43E-12SGTC_910417-1751 58.4 μMChemDiv (Drug-like library)67956240.192308Golgi
0.0856.95E-11SGTC_2737bleomycin 30.5 nMMiscellaneous162113180.0216216Golgi
0.0814.48E-10SGTC_6320781-2353 4.7 μMChemDiv (Drug-like library)68115150.146341Golgi
0.0808.11E-10SGTC_32699137823 49.5 μMChembridge (Drug-like library)176829360.070588260S ribosome export
0.0791.19E-9SGTC_29237992654 58.1 μMChembridge (Drug-like library)29851260.0769231Golgi
0.0782.37E-9SGTC_29005328528 85.3 μMChembridge (Drug-like library)7953590.0519481Golgi
0.0766.11E-9SGTC_22426630449 61.3 μMChembridge (Fragment library)6912490.0547945Golgi
0.0741.24E-8SGTC_1783st039459 87.5 μMTimTec (Natural product derivative library)7297610.0547945Golgi
0.0741.34E-8SGTC_6441498-1197 63.3 μMChemDiv (Drug-like library)67416150.40678
0.0732.20E-8SGTC_3660181-0206 4.3 μMChemDiv (Drug-like library)2748740.0666667Golgi
0.0715.65E-8SGTC_24605552655 174.2 μMMiscellaneous54019890.108108amide catabolism
0.0707.98E-8SGTC_2685mycophenolic acid 18.9 μMMiscellaneous4465410.0681818RNA pol III & RNase P/MRP
0.0681.57E-7SGTC_33109130229 44.1 μMChembridge (Drug-like library)77612580.0493827Golgi

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_6441498-119763.3 μM0.406786741615ChemDiv (Drug-like library)291.343782.86623
SGTC_6671498-104459 μM0.406786739982ChemDiv (Drug-like library)291.300722.77924RPP1 & pyrimidine depletion
SGTC_7181130-0073349 μM0.46740020ChemDiv (Drug-like library)282.724343.20213
SGTC_7851270-011165.3 μM0.3934436741994ChemDiv (Drug-like library)307.300122.53735
SGTC_780336-0123156.75 μM0.3582096765896ChemDiv (Drug-like library)380.461645.15814
SGTC_8981000-084928.3 μM0.343756751807ChemDiv (Drug-like library)356.374042.72334
SGTC_940334-0113514.75 μM0.3428576795178ChemDiv (Drug-like library)388.525164.98514
SGTC_1280906-298113.37 μM0.3333336740226ChemDiv (Drug-like library)296.343682.0124
SGTC_8282074-0507139 μM0.328767X828ChemDiv (Drug-like library)397.856346.19732RPP1 & pyrimidine depletion
SGTC_3740880-023182.3 μM0.3108116833587ChemDiv (Drug-like library)382.43453.24523iron homeostasis