1193-0155

4,5-diphenylthiophene-3-carboxylic acid

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1180
Screen concentration 285.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 2921347
SMILES C1=CC=C(C=C1)C2=C(SC=C2C(=O)O)C3=CC=CC=C3
Standardized SMILES OC(=O)c1csc(c2ccccc2)c1c3ccccc3
Molecular weight 280.341
ALogP 4.45
H-bond donor count 1
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 12.37
% growth inhibition (Hom. pool) 4.61


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 2921347
Download HIP data (tab-delimited text)  (excel)
Gene:CCT4(YDL143W)|FD-Score:4.38|P-value:5.83E-6|Clearance:0.66||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:MES1(YGR264C)|FD-Score:3.42|P-value:3.18E-4|Clearance:0.14||SGD DESC:Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs Gene:NHP2(YDL208W)|FD-Score:3.27|P-value:5.29E-4|Clearance:0.21||SGD DESC:Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing Gene:NOP4(YPL043W)|FD-Score:-3.52|P-value:2.20E-4|Clearance:0||SGD DESC:Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs) Gene:RPC31(YNL151C)|FD-Score:5.86|P-value:2.32E-9|Clearance:1.48||SGD DESC:RNA polymerase III subunit C31 Gene:RRN3(YKL125W)|FD-Score:3.72|P-value:9.91E-5|Clearance:0.23||SGD DESC:Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo Gene:SDS22(YKL193C)|FD-Score:-3.22|P-value:6.44E-4|Clearance:0||SGD DESC:Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function Gene:SNU56(YDR240C)|FD-Score:3.49|P-value:2.38E-4|Clearance:0.08||SGD DESC:Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex Gene:SPC25(YER018C)|FD-Score:-4.49|P-value:3.50E-6|Clearance:0||SGD DESC:Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering Gene:CCT4(YDL143W)|FD-Score:4.38|P-value:5.83E-6|Clearance:0.66||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:MES1(YGR264C)|FD-Score:3.42|P-value:3.18E-4|Clearance:0.14||SGD DESC:Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs Gene:NHP2(YDL208W)|FD-Score:3.27|P-value:5.29E-4|Clearance:0.21||SGD DESC:Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing Gene:NOP4(YPL043W)|FD-Score:-3.52|P-value:2.20E-4|Clearance:0||SGD DESC:Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs) Gene:RPC31(YNL151C)|FD-Score:5.86|P-value:2.32E-9|Clearance:1.48||SGD DESC:RNA polymerase III subunit C31 Gene:RRN3(YKL125W)|FD-Score:3.72|P-value:9.91E-5|Clearance:0.23||SGD DESC:Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo Gene:SDS22(YKL193C)|FD-Score:-3.22|P-value:6.44E-4|Clearance:0||SGD DESC:Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function Gene:SNU56(YDR240C)|FD-Score:3.49|P-value:2.38E-4|Clearance:0.08||SGD DESC:Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex Gene:SPC25(YER018C)|FD-Score:-4.49|P-value:3.50E-6|Clearance:0||SGD DESC:Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 2921347
Download HOP data (tab-delimited text)  (excel)
Gene:APS1(YLR170C)|FD-Score:3.53|P-value:2.08E-4||SGD DESC:Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex Gene:AVT1(YJR001W)|FD-Score:3.7|P-value:1.07E-4||SGD DESC:Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gene:BRR1(YPR057W)|FD-Score:3.18|P-value:7.36E-4||SGD DESC:snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed Gene:BUD30(YDL151C_d)|FD-Score:4.67|P-value:1.48E-6||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:CDC50(YCR094W)|FD-Score:4.1|P-value:2.09E-5||SGD DESC:Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication Gene:CNB1(YKL190W)|FD-Score:-3.24|P-value:6.05E-4||SGD DESC:Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress Gene:COQ3(YOL096C)|FD-Score:-4.76|P-value:9.79E-7||SGD DESC:O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein Gene:CTF18(YMR078C)|FD-Score:-3.69|P-value:1.13E-4||SGD DESC:Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint Gene:CYK3(YDL117W)|FD-Score:-4.46|P-value:4.17E-6||SGD DESC:SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants Gene:DAL1(YIR027C)|FD-Score:3.37|P-value:3.69E-4||SGD DESC:Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression Gene:DSE2(YHR143W)|FD-Score:3.82|P-value:6.72E-5||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP Gene:ELP4(YPL101W)|FD-Score:3.32|P-value:4.45E-4||SGD DESC:Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity Gene:HIS3(YOR202W)|FD-Score:3.56|P-value:1.83E-4||SGD DESC:Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p Gene:HOS2(YGL194C)|FD-Score:3.25|P-value:5.82E-4||SGD DESC:Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS Gene:INO2(YDR123C)|FD-Score:-3.25|P-value:5.79E-4||SGD DESC:Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion Gene:IRA2(YOL081W)|FD-Score:4.33|P-value:7.30E-6||SGD DESC:GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; similar to human neurofibromin; IRA2 has a paralog, IRA1, that arose from the whole genome duplication Gene:IRS4(YKR019C)|FD-Score:3.81|P-value:6.82E-5||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:MHR1(YDR296W)|FD-Score:3.2|P-value:6.76E-4||SGD DESC:Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress Gene:MKC7(YDR144C)|FD-Score:3.24|P-value:5.98E-4||SGD DESC:GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p Gene:NAT1(YDL040C)|FD-Score:4.49|P-value:3.49E-6||SGD DESC:Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing Gene:NIS1(YNL078W)|FD-Score:3.42|P-value:3.17E-4||SGD DESC:Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network Gene:NOT3(YIL038C)|FD-Score:3.13|P-value:8.60E-4||SGD DESC:Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation Gene:OCA5(YHL029C_p)|FD-Score:3.4|P-value:3.42E-4||SGD DESC:Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts Gene:PEX11(YOL147C)|FD-Score:3.43|P-value:2.98E-4||SGD DESC:Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p Gene:POP2(YNR052C)|FD-Score:3.65|P-value:1.29E-4||SGD DESC:RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation Gene:PRM2(YIL037C)|FD-Score:4.36|P-value:6.38E-6||SGD DESC:Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion Gene:PRY2(YKR013W)|FD-Score:3.5|P-value:2.32E-4||SGD DESC:Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication Gene:RAD1(YPL022W)|FD-Score:4.66|P-value:1.57E-6||SGD DESC:Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein Gene:ROM1(YGR070W)|FD-Score:3.48|P-value:2.53E-4||SGD DESC:GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP Gene:RPL20B(YOR312C)|FD-Score:3.48|P-value:2.47E-4||SGD DESC:Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication Gene:RPS14A(YCR031C)|FD-Score:3.5|P-value:2.29E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14A has a paralog, RPS14B, that arose from the whole genome duplication Gene:RPS21A(YKR057W)|FD-Score:4.05|P-value:2.58E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication Gene:RRT5(YFR032C_p)|FD-Score:3.92|P-value:4.36E-5||SGD DESC:Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation Gene:RTG2(YGL252C)|FD-Score:3.27|P-value:5.36E-4||SGD DESC:Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p Gene:SAC6(YDR129C)|FD-Score:5.05|P-value:2.21E-7||SGD DESC:Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:SAM1(YLR180W)|FD-Score:-3.28|P-value:5.18E-4||SGD DESC:S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication Gene:SER2(YGR208W)|FD-Score:-3.49|P-value:2.38E-4||SGD DESC:Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source Gene:SGF11(YPL047W)|FD-Score:3.21|P-value:6.73E-4||SGD DESC:Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation Gene:SIP3(YNL257C)|FD-Score:3.27|P-value:5.37E-4||SGD DESC:Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication Gene:SLA1(YBL007C)|FD-Score:-3.31|P-value:4.66E-4||SGD DESC:Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains Gene:SLX9(YGR081C)|FD-Score:3.45|P-value:2.76E-4||SGD DESC:Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant Gene:SNF6(YHL025W)|FD-Score:-7.66|P-value:9.28E-15||SGD DESC:Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions Gene:SPS100(YHR139C)|FD-Score:4.49|P-value:3.61E-6||SGD DESC:Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin Gene:TAZ1(YPR140W)|FD-Score:3.49|P-value:2.46E-4||SGD DESC:Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome Gene:TDP1(YBR223C)|FD-Score:-3.51|P-value:2.27E-4||SGD DESC:Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI Gene:THI21(YPL258C)|FD-Score:5.13|P-value:1.48E-7||SGD DESC:Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p Gene:TRM44(YPL030W)|FD-Score:3.27|P-value:5.37E-4||SGD DESC:tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene Gene:UFD2(YDL190C)|FD-Score:3.15|P-value:8.15E-4||SGD DESC:Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3 Gene:UTR4(YEL038W)|FD-Score:3.24|P-value:6.08E-4||SGD DESC:Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus Gene:VPS1(YKR001C)|FD-Score:3.22|P-value:6.35E-4||SGD DESC:Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis Gene:YDR056C(YDR056C_p)|FD-Score:-3.33|P-value:4.38E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein Gene:YEL045C(YEL045C_d)|FD-Score:-3.38|P-value:3.60E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress Gene:YER158C(YER158C_p)|FD-Score:5.02|P-value:2.58E-7||SGD DESC:Protein of unknown function; potentially phosphorylated by Cdc28p; YER158C has a paralog, AFR1, that arose from the whole genome duplication Gene:YGL101W(YGL101W_p)|FD-Score:3.25|P-value:5.76E-4||SGD DESC:Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p Gene:YGR018C(YGR018C_p)|FD-Score:3.5|P-value:2.29E-4||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W Gene:YGR146C-A(YGR146C-A_p)|FD-Score:3.19|P-value:7.05E-4||SGD DESC:Putative protein of unknown function Gene:YHR112C(YHR112C)|FD-Score:3.47|P-value:2.61E-4||SGD DESC:Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway Gene:YKL118W(YKL118W_d)|FD-Score:3.33|P-value:4.34E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2 Gene:YLL059C(YLL059C_d)|FD-Score:4.24|P-value:1.11E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YLR049C(YLR049C_p)|FD-Score:4.48|P-value:3.68E-6||SGD DESC:Putative protein of unknown function Gene:YMR244W(YMR244W_p)|FD-Score:-3.36|P-value:3.85E-4||SGD DESC:Putative protein of unknown function Gene:YNL143C(YNL143C_p)|FD-Score:3.68|P-value:1.15E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YNR014W(YNR014W_p)|FD-Score:3.12|P-value:8.99E-4||SGD DESC:Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication Gene:YPL034W(YPL034W_p)|FD-Score:-3.29|P-value:5.09E-4||SGD DESC:Putative protein of unknown function; YPL034W is not essential gene Gene:YPT53(YNL093W)|FD-Score:3.86|P-value:5.67E-5||SGD DESC:Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication Gene:APS1(YLR170C)|FD-Score:3.53|P-value:2.08E-4||SGD DESC:Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex Gene:AVT1(YJR001W)|FD-Score:3.7|P-value:1.07E-4||SGD DESC:Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gene:BRR1(YPR057W)|FD-Score:3.18|P-value:7.36E-4||SGD DESC:snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed Gene:BUD30(YDL151C_d)|FD-Score:4.67|P-value:1.48E-6||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:CDC50(YCR094W)|FD-Score:4.1|P-value:2.09E-5||SGD DESC:Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication Gene:CNB1(YKL190W)|FD-Score:-3.24|P-value:6.05E-4||SGD DESC:Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress Gene:COQ3(YOL096C)|FD-Score:-4.76|P-value:9.79E-7||SGD DESC:O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein Gene:CTF18(YMR078C)|FD-Score:-3.69|P-value:1.13E-4||SGD DESC:Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint Gene:CYK3(YDL117W)|FD-Score:-4.46|P-value:4.17E-6||SGD DESC:SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants Gene:DAL1(YIR027C)|FD-Score:3.37|P-value:3.69E-4||SGD DESC:Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression Gene:DSE2(YHR143W)|FD-Score:3.82|P-value:6.72E-5||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP Gene:ELP4(YPL101W)|FD-Score:3.32|P-value:4.45E-4||SGD DESC:Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity Gene:HIS3(YOR202W)|FD-Score:3.56|P-value:1.83E-4||SGD DESC:Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p Gene:HOS2(YGL194C)|FD-Score:3.25|P-value:5.82E-4||SGD DESC:Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS Gene:INO2(YDR123C)|FD-Score:-3.25|P-value:5.79E-4||SGD DESC:Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion Gene:IRA2(YOL081W)|FD-Score:4.33|P-value:7.30E-6||SGD DESC:GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; similar to human neurofibromin; IRA2 has a paralog, IRA1, that arose from the whole genome duplication Gene:IRS4(YKR019C)|FD-Score:3.81|P-value:6.82E-5||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:MHR1(YDR296W)|FD-Score:3.2|P-value:6.76E-4||SGD DESC:Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress Gene:MKC7(YDR144C)|FD-Score:3.24|P-value:5.98E-4||SGD DESC:GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p Gene:NAT1(YDL040C)|FD-Score:4.49|P-value:3.49E-6||SGD DESC:Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing Gene:NIS1(YNL078W)|FD-Score:3.42|P-value:3.17E-4||SGD DESC:Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network Gene:NOT3(YIL038C)|FD-Score:3.13|P-value:8.60E-4||SGD DESC:Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation Gene:OCA5(YHL029C_p)|FD-Score:3.4|P-value:3.42E-4||SGD DESC:Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts Gene:PEX11(YOL147C)|FD-Score:3.43|P-value:2.98E-4||SGD DESC:Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p Gene:POP2(YNR052C)|FD-Score:3.65|P-value:1.29E-4||SGD DESC:RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation Gene:PRM2(YIL037C)|FD-Score:4.36|P-value:6.38E-6||SGD DESC:Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion Gene:PRY2(YKR013W)|FD-Score:3.5|P-value:2.32E-4||SGD DESC:Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication Gene:RAD1(YPL022W)|FD-Score:4.66|P-value:1.57E-6||SGD DESC:Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein Gene:ROM1(YGR070W)|FD-Score:3.48|P-value:2.53E-4||SGD DESC:GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP Gene:RPL20B(YOR312C)|FD-Score:3.48|P-value:2.47E-4||SGD DESC:Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication Gene:RPS14A(YCR031C)|FD-Score:3.5|P-value:2.29E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14A has a paralog, RPS14B, that arose from the whole genome duplication Gene:RPS21A(YKR057W)|FD-Score:4.05|P-value:2.58E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication Gene:RRT5(YFR032C_p)|FD-Score:3.92|P-value:4.36E-5||SGD DESC:Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation Gene:RTG2(YGL252C)|FD-Score:3.27|P-value:5.36E-4||SGD DESC:Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p Gene:SAC6(YDR129C)|FD-Score:5.05|P-value:2.21E-7||SGD DESC:Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:SAM1(YLR180W)|FD-Score:-3.28|P-value:5.18E-4||SGD DESC:S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication Gene:SER2(YGR208W)|FD-Score:-3.49|P-value:2.38E-4||SGD DESC:Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source Gene:SGF11(YPL047W)|FD-Score:3.21|P-value:6.73E-4||SGD DESC:Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation Gene:SIP3(YNL257C)|FD-Score:3.27|P-value:5.37E-4||SGD DESC:Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication Gene:SLA1(YBL007C)|FD-Score:-3.31|P-value:4.66E-4||SGD DESC:Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains Gene:SLX9(YGR081C)|FD-Score:3.45|P-value:2.76E-4||SGD DESC:Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant Gene:SNF6(YHL025W)|FD-Score:-7.66|P-value:9.28E-15||SGD DESC:Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions Gene:SPS100(YHR139C)|FD-Score:4.49|P-value:3.61E-6||SGD DESC:Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin Gene:TAZ1(YPR140W)|FD-Score:3.49|P-value:2.46E-4||SGD DESC:Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome Gene:TDP1(YBR223C)|FD-Score:-3.51|P-value:2.27E-4||SGD DESC:Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI Gene:THI21(YPL258C)|FD-Score:5.13|P-value:1.48E-7||SGD DESC:Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p Gene:TRM44(YPL030W)|FD-Score:3.27|P-value:5.37E-4||SGD DESC:tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene Gene:UFD2(YDL190C)|FD-Score:3.15|P-value:8.15E-4||SGD DESC:Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3 Gene:UTR4(YEL038W)|FD-Score:3.24|P-value:6.08E-4||SGD DESC:Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus Gene:VPS1(YKR001C)|FD-Score:3.22|P-value:6.35E-4||SGD DESC:Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis Gene:YDR056C(YDR056C_p)|FD-Score:-3.33|P-value:4.38E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein Gene:YEL045C(YEL045C_d)|FD-Score:-3.38|P-value:3.60E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress Gene:YER158C(YER158C_p)|FD-Score:5.02|P-value:2.58E-7||SGD DESC:Protein of unknown function; potentially phosphorylated by Cdc28p; YER158C has a paralog, AFR1, that arose from the whole genome duplication Gene:YGL101W(YGL101W_p)|FD-Score:3.25|P-value:5.76E-4||SGD DESC:Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p Gene:YGR018C(YGR018C_p)|FD-Score:3.5|P-value:2.29E-4||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W Gene:YGR146C-A(YGR146C-A_p)|FD-Score:3.19|P-value:7.05E-4||SGD DESC:Putative protein of unknown function Gene:YHR112C(YHR112C)|FD-Score:3.47|P-value:2.61E-4||SGD DESC:Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway Gene:YKL118W(YKL118W_d)|FD-Score:3.33|P-value:4.34E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2 Gene:YLL059C(YLL059C_d)|FD-Score:4.24|P-value:1.11E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YLR049C(YLR049C_p)|FD-Score:4.48|P-value:3.68E-6||SGD DESC:Putative protein of unknown function Gene:YMR244W(YMR244W_p)|FD-Score:-3.36|P-value:3.85E-4||SGD DESC:Putative protein of unknown function Gene:YNL143C(YNL143C_p)|FD-Score:3.68|P-value:1.15E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YNR014W(YNR014W_p)|FD-Score:3.12|P-value:8.99E-4||SGD DESC:Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication Gene:YPL034W(YPL034W_p)|FD-Score:-3.29|P-value:5.09E-4||SGD DESC:Putative protein of unknown function; YPL034W is not essential gene Gene:YPT53(YNL093W)|FD-Score:3.86|P-value:5.67E-5||SGD DESC:Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YNL151C5.862.32E-91.48RPC31RNA polymerase III subunit C31
YDL143W4.385.83E-60.66CCT4Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YKL125W3.729.91E-50.23RRN3Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo
YDR240C3.492.38E-40.08SNU56Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex
YGR264C3.423.18E-40.14MES1Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
YDL208W3.275.29E-40.21NHP2Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing
YCR057C3.060.001090.09PWP2Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis
YGR114C_d2.970.001480.06YGR114C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6
YNL002C2.910.001800.07RLP7Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs
YOR149C2.840.002220.03SMP3Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure
YBR252W2.810.002440.05DUT1deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate
YMR288W2.770.002810.01HSH155U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155
YDR526C_d2.760.002920.00YDR526C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL014W2.750.002960.03CCT3Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YPR085C2.730.003200.02ASA1Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YPL258C5.131.48E-7THI21Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p
YDR129C5.052.21E-7SAC6Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress
YER158C_p5.022.58E-7YER158C_pProtein of unknown function; potentially phosphorylated by Cdc28p; YER158C has a paralog, AFR1, that arose from the whole genome duplication
YDL151C_d4.671.48E-6BUD30_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YPL022W4.661.57E-6RAD1Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein
YDL040C4.493.49E-6NAT1Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
YHR139C4.493.61E-6SPS100Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin
YLR049C_p4.483.68E-6YLR049C_pPutative protein of unknown function
YIL037C4.366.38E-6PRM2Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion
YOL081W4.337.30E-6IRA2GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; similar to human neurofibromin; IRA2 has a paralog, IRA1, that arose from the whole genome duplication
YLL059C_d4.241.11E-5YLL059C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCR094W4.102.09E-5CDC50Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication
YKR057W4.052.58E-5RPS21AProtein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication
YFR032C_p3.924.36E-5RRT5_pPutative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation
YNL093W3.865.67E-5YPT53Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication

GO enrichment analysis for SGTC_1180
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1031.70E-15SGTC_11921488-0095 21.4 μMChemDiv (Drug-like library)9158750.0833333
0.0953.32E-13SGTC_13581509-0022 2.5 μMChemDiv (Drug-like library)32584340.0701754
0.0912.09E-12SGTC_12660828-0227 32.9 μMChemDiv (Drug-like library)39138200.134615
0.0848.20E-11SGTC_12092323-2347 50.3 μMChemDiv (Drug-like library)54127600.166667
0.0841.17E-10SGTC_11473809-1045 12.3 μMChemDiv (Drug-like library)3259250.148936
0.0681.50E-7SGTC_12740865-0114 173.0 μMChemDiv (Drug-like library)8706240.08
0.0672.39E-7SGTC_11313454-3128 32.3 μMChemDiv (Drug-like library)7109820.0793651
0.0663.77E-7SGTC_23579067248 200.0 μMChembridge (Fragment library)91502350.0925926
0.0663.97E-7SGTC_23559061122 103.1 μMChembridge (Fragment library)53029570.183673
0.0654.87E-7SGTC_12560570-0116 285.0 μMChemDiv (Drug-like library)4106380.0363636
0.0655.51E-7SGTC_1168k815-0004 80.5 μMChemDiv (Drug-like library)6424330.0714286DNA damage response
0.0631.13E-6SGTC_980074-0023 107.7 μMChemDiv (Drug-like library)35638210.176471Golgi
0.0621.96E-6SGTC_23569061756 189.0 μMChembridge (Fragment library)201040430.116667
0.0621.98E-6SGTC_11861319-0216 26.0 μMChemDiv (Drug-like library)45651360.0649351
0.0603.84E-6SGTC_13631636-0063 10.4 μMChemDiv (Drug-like library)60721850.101695Golgi

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_2235salicylic acid500 μM0.382353338Miscellaneous138.120741.21723
SGTC_18233-hydroxy-2-naphthoic acid106 μM0.3421057104TimTec (Natural product derivative library)188.179422.12623
SGTC_21355326629150.42 μM0.3255020077Chembridge (Fragment library)174.19592.03312RPP1 & pyrimidine depletion
SGTC_530973-002339.98 μM0.28674768ChemDiv (Drug-like library)261.33943.3714RNA processing & uracil transport
SGTC_3043909230349.47 μM0.2825236084Chembridge (Drug-like library)299.430443.97302
SGTC_23829035899200 μM0.274516462679Chembridge (Fragment library)288.368041.9431460S ribosome export
SGTC_1796st049173110.4 μM0.26829394134TimTec (Natural product derivative library)181.18854-2.43734
SGTC_2552juarezic acid87.02 μM0.2682931549512Microsource (Natural product library)174.19592.39512TSC3-RPN4
SGTC_21945927483104.55 μM0.266667760979Chembridge (Fragment library)201.221241.89112
SGTC_8670518-0118155 μM0.2653066848158ChemDiv (Drug-like library)256.256681.40235DNA intercalators