Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YNR043W | 5.79 | 3.43E-9 | 1.74 | MVD1 | Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer |
YDL205C | 4.05 | 2.51E-5 | 0.27 | HEM3 | Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme |
YNL308C | 3.78 | 7.75E-5 | 0.57 | KRI1 | Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p |
YJL167W | 3.21 | 6.69E-4 | 0.10 | ERG20 | Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis |
YCR052W | 3.10 | 9.57E-4 | 0.00 | RSC6 | Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p |
YMR268C | 3.10 | 9.66E-4 | 0.01 | PRP24 | Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling |
YLR005W | 3.09 | 9.99E-4 | 0.12 | SSL1 | Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p |
YOL069W | 2.97 | 0.00148 | 0.01 | NUF2 | Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering |
YML127W | 2.96 | 0.00151 | 0.01 | RSC9 | Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway |
YGL040C | 2.96 | 0.00156 | 0.07 | HEM2 | Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus |
YLR051C | 2.88 | 0.00198 | 0.11 | FCF2 | Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon |
YLR076C_d | 2.77 | 0.00277 | 0.10 | YLR076C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10 |
YDR118W | 2.68 | 0.00372 | 0.05 | APC4 | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress |
YDR002W | 2.63 | 0.00426 | 0.03 | YRB1 | Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1 |
YMR290C | 2.60 | 0.00460 | 0.00 | HAS1 | ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles |