Deletion Strain | FD score | P-value | Gene | Gene Description |
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YOR070C | 22.20 | 1.03E-109 | GYP1 | Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion |
YLL040C | 18.00 | 8.27E-73 | VPS13 | Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively |
YOR162C | 14.70 | 3.72E-49 | YRR1 | Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication |
YCR024C | 12.70 | 1.86E-37 | SLM5 | Mitochondrial asparaginyl-tRNA synthetase |
YOR158W | 10.10 | 3.41E-24 | PET123 | Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator |
YKR019C | 10.00 | 6.39E-24 | IRS4 | EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication |
YGL005C | 9.08 | 5.32E-20 | COG7 | Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments |
YGL054C | 8.55 | 6.08E-18 | ERV14 | COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication |
YOR036W | 8.18 | 1.43E-16 | PEP12 | Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin |
YNL213C | 8.08 | 3.36E-16 | RRG9 | Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
YKL068W-A_p | 7.80 | 3.11E-15 | YKL068W-A_p | Putative protein of unknown function; identified by homology to Ashbya gossypii |
YPL148C | 7.31 | 1.31E-13 | PPT2 | Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation |
YOR109W | 7.29 | 1.50E-13 | INP53 | Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains |
YHL004W | 7.21 | 2.74E-13 | MRP4 | Mitochondrial ribosomal protein of the small subunit |
YDR320C | 7.01 | 1.17E-12 | SWA2 | Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles |