Deletion Strain | FD score | P-value | Gene | Gene Description |
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YKR080W | 6.81 | 4.75E-12 | MTD1 | NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline |
YPR118W | 6.42 | 6.69E-11 | MRI1 | 5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway |
YHR010W | 4.84 | 6.42E-7 | RPL27A | Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication |
YMR300C | 4.66 | 1.57E-6 | ADE4 | Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway |
YGR252W | 4.58 | 2.34E-6 | GCN5 | Acetyltransferase, modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation |
YMR075W | 4.57 | 2.44E-6 | RCO1 | Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p |
YGL220W | 4.52 | 3.11E-6 | FRA2 | Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel |
YFL007W | 4.49 | 3.51E-6 | BLM10 | Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200 |
YOR135C_d | 4.43 | 4.66E-6 | IRC14_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci |
YAL008W | 4.40 | 5.32E-6 | FUN14 | Mitochondrial protein of unknown function |
YKR043C | 4.02 | 2.94E-5 | SHB17 | Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus |
YMR245W_d | 3.95 | 3.97E-5 | YMR245W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YER090W | 3.88 | 5.12E-5 | TRP2 | Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p |
YNL084C | 3.86 | 5.70E-5 | END3 | EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p |
YPL157W | 3.83 | 6.36E-5 | TGS1 | Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs |