Deletion Strain | FD score | P-value | Gene | Gene Description |
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YKL211C | 22.80 | 1.63E-115 | TRP3 | Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p |
YDR008C_d | 7.98 | 7.10E-16 | YDR008C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YER090W | 7.34 | 1.03E-13 | TRP2 | Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p |
YOL110W | 6.91 | 2.45E-12 | SHR5 | Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization |
YKR045C_p | 6.53 | 3.28E-11 | YKR045C_p | Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm |
YNL237W | 6.31 | 1.38E-10 | YTP1 | Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins |
YML122C_d | 6.10 | 5.27E-10 | YML122C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YDR354W | 6.06 | 6.93E-10 | TRP4 | Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis |
YDR069C | 5.38 | 3.64E-8 | DOA4 | Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole |
YEL059W_d | 5.36 | 4.24E-8 | HHY1_d | Dubious open reading frame unlikely to encode a functional protein; mutant is hypersensitive to hygromycin B indicative of defects in vacuolar trafficking |
YCL039W | 4.87 | 5.61E-7 | GID7 | Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions |
YPR069C | 4.86 | 5.73E-7 | SPE3 | Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells |
YGL056C | 4.78 | 8.90E-7 | SDS23 | One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication |
YPR100W | 4.75 | 1.04E-6 | MRPL51 | Mitochondrial ribosomal protein of the large subunit |
YGL148W | 4.68 | 1.45E-6 | ARO2 | Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress |