Deletion Strain | FD score | P-value | Gene | Gene Description |
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YKL211C | 23.40 | 7.81E-122 | TRP3 | Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p |
YER090W | 8.80 | 6.65E-19 | TRP2 | Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p |
YIR023W | 6.28 | 1.64E-10 | DAL81 | Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism |
YOR213C | 6.20 | 2.78E-10 | SAS5 | Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity |
YJL088W | 6.06 | 7.01E-10 | ARG3 | Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine |
YER086W | 6.02 | 8.53E-10 | ILV1 | Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation |
YCR017C | 5.75 | 4.55E-9 | CWH43 | Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion |
YER166W | 5.65 | 8.07E-9 | DNF1 | Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase |
YGL148W | 5.54 | 1.50E-8 | ARO2 | Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress |
YLR461W | 5.46 | 2.35E-8 | PAU4 | Member of the seripauperin multigene family encoded mainly in subtelomeric regions; active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme |
YNL086W_p | 5.42 | 3.02E-8 | SNN1_p | Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes |
YOR070C | 5.19 | 1.05E-7 | GYP1 | Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion |
YDR078C | 5.16 | 1.23E-7 | SHU2 | Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function |
YMR202W | 4.98 | 3.18E-7 | ERG2 | C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis |
YMR001C-A_p | 4.89 | 5.15E-7 | YMR001C-A_p | Putative protein of unknown function |