Deletion Strain | FD score | P-value | Gene | Gene Description |
---|
YGL071W | 8.12 | 2.39E-16 | AFT1 | Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress |
YCR026C | 5.78 | 3.72E-9 | NPP1 | Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP1 has a paralog, NPP2, that arose from the whole genome duplication |
YLR189C | 5.28 | 6.34E-8 | ATG26 | UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy |
YJR050W | 5.25 | 7.58E-8 | ISY1 | Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles |
YGR285C | 5.04 | 2.38E-7 | ZUO1 | Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p |
YMR077C | 5.03 | 2.46E-7 | VPS20 | Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes |
YHR184W | 4.73 | 1.12E-6 | SSP1 | Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis |
YHR132C | 4.68 | 1.42E-6 | ECM14 | Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly |
YCR036W | 4.49 | 3.55E-6 | RBK1 | Putative ribokinase |
YFR043C | 4.39 | 5.62E-6 | IRC6 | Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci |
YNL025C | 4.36 | 6.57E-6 | SSN8 | Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance |
YPR024W | 4.34 | 7.09E-6 | YME1 | Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover |
YBL096C_d | 4.34 | 7.20E-6 | YBL096C_d | Non-essential protein of unknown function |
YKR072C | 4.34 | 7.29E-6 | SIS2 | Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis |
YIL053W | 4.33 | 7.51E-6 | RHR2 | Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication |