1643-0193

2-(4-chloro-2-methylphenoxy)-N-[(Z)-(3-nitrophenyl)methylideneamino]acetamide

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1200
Screen concentration 18.4 μM
Source ChemDiv (Drug-like library)
PubChem CID 5403974
SMILES CC1=C(C=CC(=C1)Cl)OCC(=O)NN=CC2=CC(=CC=C2)[N+](=O)[O-]
Standardized SMILES Cc1cc(Cl)ccc1OCC(=O)NN=Cc2cccc(c2)[N+](=O)[O-]
Molecular weight 347.7531
ALogP 3.56
H-bond donor count 1
H-bond acceptor count 5
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 20.03
% growth inhibition (Hom. pool) 3.62


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 5403974
Download HIP data (tab-delimited text)  (excel)
Gene:CCT5(YJR064W)|FD-Score:3.26|P-value:5.64E-4|Clearance:0.08||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:CDC34(YDR054C)|FD-Score:3.1|P-value:9.66E-4|Clearance:0.16||SGD DESC:Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress Gene:CFT2(YLR115W)|FD-Score:-3.18|P-value:7.33E-4|Clearance:0||SGD DESC:Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein. Gene:MAS2(YHR024C)|FD-Score:-3.17|P-value:7.53E-4|Clearance:0||SGD DESC:Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins Gene:MCD4(YKL165C)|FD-Score:4.51|P-value:3.26E-6|Clearance:0.72||SGD DESC:Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes Gene:NAT2(YGR147C)|FD-Score:4.89|P-value:5.11E-7|Clearance:0.72||SGD DESC:Protein with an apparent role in acetylation of N-terminal methionine residues Gene:NHP2(YDL208W)|FD-Score:-4.01|P-value:3.01E-5|Clearance:0||SGD DESC:Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing Gene:NOP53(YPL146C)|FD-Score:3.32|P-value:4.46E-4|Clearance:0.07||SGD DESC:Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired Gene:NOP56(YLR197W)|FD-Score:3.79|P-value:7.65E-5|Clearance:0.24||SGD DESC:Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects Gene:RET1(YOR207C)|FD-Score:3.18|P-value:7.40E-4|Clearance:0.08||SGD DESC:Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs Gene:RIO1(YOR119C)|FD-Score:-3.23|P-value:6.22E-4|Clearance:0||SGD DESC:Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA Gene:RPN12(YFR052W)|FD-Score:4.7|P-value:1.31E-6|Clearance:0.72||SGD DESC:Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress Gene:RSM10(YDR041W)|FD-Score:3.53|P-value:2.07E-4|Clearance:0.14||SGD DESC:Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins Gene:SSU72(YNL222W)|FD-Score:3.79|P-value:7.55E-5|Clearance:0||SGD DESC:Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo Gene:TAO3(YIL129C)|FD-Score:3.39|P-value:3.52E-4|Clearance:0.07||SGD DESC:Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p Gene:YAH1(YPL252C)|FD-Score:3.54|P-value:1.98E-4|Clearance:0.01||SGD DESC:Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin Gene:YDL196W(YDL196W_d)|FD-Score:-5.04|P-value:2.35E-7|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 Gene:YMR290W-A(YMR290W-A_d)|FD-Score:5.6|P-value:1.09E-8|Clearance:0.72||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase Gene:YPR177C(YPR177C_d)|FD-Score:-3.96|P-value:3.74E-5|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex Gene:CCT5(YJR064W)|FD-Score:3.26|P-value:5.64E-4|Clearance:0.08||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:CDC34(YDR054C)|FD-Score:3.1|P-value:9.66E-4|Clearance:0.16||SGD DESC:Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress Gene:CFT2(YLR115W)|FD-Score:-3.18|P-value:7.33E-4|Clearance:0||SGD DESC:Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein. Gene:MAS2(YHR024C)|FD-Score:-3.17|P-value:7.53E-4|Clearance:0||SGD DESC:Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins Gene:MCD4(YKL165C)|FD-Score:4.51|P-value:3.26E-6|Clearance:0.72||SGD DESC:Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes Gene:NAT2(YGR147C)|FD-Score:4.89|P-value:5.11E-7|Clearance:0.72||SGD DESC:Protein with an apparent role in acetylation of N-terminal methionine residues Gene:NHP2(YDL208W)|FD-Score:-4.01|P-value:3.01E-5|Clearance:0||SGD DESC:Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing Gene:NOP53(YPL146C)|FD-Score:3.32|P-value:4.46E-4|Clearance:0.07||SGD DESC:Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired Gene:NOP56(YLR197W)|FD-Score:3.79|P-value:7.65E-5|Clearance:0.24||SGD DESC:Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects Gene:RET1(YOR207C)|FD-Score:3.18|P-value:7.40E-4|Clearance:0.08||SGD DESC:Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs Gene:RIO1(YOR119C)|FD-Score:-3.23|P-value:6.22E-4|Clearance:0||SGD DESC:Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA Gene:RPN12(YFR052W)|FD-Score:4.7|P-value:1.31E-6|Clearance:0.72||SGD DESC:Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress Gene:RSM10(YDR041W)|FD-Score:3.53|P-value:2.07E-4|Clearance:0.14||SGD DESC:Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins Gene:SSU72(YNL222W)|FD-Score:3.79|P-value:7.55E-5|Clearance:0||SGD DESC:Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo Gene:TAO3(YIL129C)|FD-Score:3.39|P-value:3.52E-4|Clearance:0.07||SGD DESC:Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p Gene:YAH1(YPL252C)|FD-Score:3.54|P-value:1.98E-4|Clearance:0.01||SGD DESC:Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin Gene:YDL196W(YDL196W_d)|FD-Score:-5.04|P-value:2.35E-7|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 Gene:YMR290W-A(YMR290W-A_d)|FD-Score:5.6|P-value:1.09E-8|Clearance:0.72||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase Gene:YPR177C(YPR177C_d)|FD-Score:-3.96|P-value:3.74E-5|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 5403974
Download HOP data (tab-delimited text)  (excel)
Gene:ARF3(YOR094W)|FD-Score:3.5|P-value:2.29E-4||SGD DESC:Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity Gene:ASG1(YIL130W)|FD-Score:3.1|P-value:9.66E-4||SGD DESC:Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance Gene:ATG26(YLR189C)|FD-Score:3.13|P-value:8.66E-4||SGD DESC:UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy Gene:ATP5(YDR298C)|FD-Score:-3.21|P-value:6.55E-4||SGD DESC:Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated Gene:BAP2(YBR068C)|FD-Score:3.13|P-value:8.87E-4||SGD DESC:High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication Gene:BDF2(YDL070W)|FD-Score:5.56|P-value:1.33E-8||SGD DESC:Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress Gene:CAF20(YOR276W)|FD-Score:3.31|P-value:4.72E-4||SGD DESC:Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E Gene:CYB5(YNL111C)|FD-Score:3.1|P-value:9.69E-4||SGD DESC:Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation Gene:DGR2(YKL121W_p)|FD-Score:5.59|P-value:1.14E-8||SGD DESC:Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds Gene:DIA3(YDL024C)|FD-Score:4.1|P-value:2.08E-5||SGD DESC:Protein of unknown function, involved in invasive and pseudohyphal growth Gene:DPH2(YKL191W)|FD-Score:4.22|P-value:1.22E-5||SGD DESC:Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p Gene:ERV14(YGL054C)|FD-Score:3.87|P-value:5.48E-5||SGD DESC:COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication Gene:FMP16(YDR070C_p)|FD-Score:3.17|P-value:7.63E-4||SGD DESC:Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress Gene:GAS5(YOL030W)|FD-Score:5.6|P-value:1.06E-8||SGD DESC:1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall Gene:GET3(YDL100C)|FD-Score:3.93|P-value:4.32E-5||SGD DESC:Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress Gene:GMC1(YDR506C)|FD-Score:3.82|P-value:6.76E-5||SGD DESC:Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein Gene:HUT1(YPL244C)|FD-Score:3.88|P-value:5.19E-5||SGD DESC:Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1 Gene:INO1(YJL153C)|FD-Score:3.74|P-value:9.12E-5||SGD DESC:Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element Gene:KTR1(YOR099W)|FD-Score:4.12|P-value:1.90E-5||SGD DESC:Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress Gene:KTR3(YBR205W)|FD-Score:4.37|P-value:6.27E-6||SGD DESC:Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress Gene:LRE1(YCL051W)|FD-Score:3.21|P-value:6.75E-4||SGD DESC:Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway; <br>LRE1 has a paralog, HLR1, that arose from the whole genome duplication Gene:LRO1(YNR008W)|FD-Score:3.1|P-value:9.78E-4||SGD DESC:Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase Gene:MSB1(YOR188W)|FD-Score:-3.12|P-value:8.93E-4||SGD DESC:Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:NDI1(YML120C)|FD-Score:3.94|P-value:3.99E-5||SGD DESC:NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; upon apoptotic stress, Ndip is activated in the mitochondria by N-terminal cleavage, and the truncated protein translocates to the cytoplasm to induce apoptosis; homolog of human AMID Gene:NIS1(YNL078W)|FD-Score:3.75|P-value:8.84E-5||SGD DESC:Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network Gene:NPC2(YDL046W)|FD-Score:3.14|P-value:8.40E-4||SGD DESC:Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes Gene:OMS1(YDR316W)|FD-Score:3.34|P-value:4.13E-4||SGD DESC:Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations Gene:PEP7(YDR323C)|FD-Score:3.82|P-value:6.65E-5||SGD DESC:Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance Gene:PEX27(YOR193W)|FD-Score:4.93|P-value:4.19E-7||SGD DESC:Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p Gene:PEX32(YBR168W)|FD-Score:3.69|P-value:1.13E-4||SGD DESC:Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p Gene:RCF1(YML030W)|FD-Score:-3.25|P-value:5.69E-4||SGD DESC:Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast Gene:RPL20A(YMR242C)|FD-Score:4.17|P-value:1.52E-5||SGD DESC:Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication Gene:SAS2(YMR127C)|FD-Score:3.29|P-value:5.06E-4||SGD DESC:Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family Gene:SEF1(YBL066C)|FD-Score:3.15|P-value:8.08E-4||SGD DESC:Putative transcription factor, has homolog in Kluyveromyces lactis Gene:SHG1(YBR258C)|FD-Score:3.61|P-value:1.55E-4||SGD DESC:Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres Gene:SHM1(YBR263W)|FD-Score:5.66|P-value:7.48E-9||SGD DESC:Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine Gene:SNF6(YHL025W)|FD-Score:-10|P-value:4.86E-24||SGD DESC:Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions Gene:SOM1(YEL059C-A)|FD-Score:3.48|P-value:2.52E-4||SGD DESC:Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs Gene:SPR1(YOR190W)|FD-Score:3.22|P-value:6.39E-4||SGD DESC:Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance Gene:SWC3(YAL011W)|FD-Score:6.26|P-value:1.89E-10||SGD DESC:Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae Gene:TAH1(YCR060W)|FD-Score:4.1|P-value:2.09E-5||SGD DESC:Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II Gene:TIP1(YBR067C)|FD-Score:3.13|P-value:8.60E-4||SGD DESC:Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins Gene:UNG1(YML021C)|FD-Score:6.15|P-value:3.96E-10||SGD DESC:Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus Gene:VPS1(YKR001C)|FD-Score:-3.25|P-value:5.85E-4||SGD DESC:Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis Gene:YBR085C-A(YBR085C-A_p)|FD-Score:3.98|P-value:3.48E-5||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress Gene:YBR287W(YBR287W_p)|FD-Score:3.41|P-value:3.31E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene Gene:YDL050C(YDL050C_d)|FD-Score:3.97|P-value:3.55E-5||SGD DESC:Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR199W(YDR199W_d)|FD-Score:-3.11|P-value:9.28E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity Gene:YNR029C(YNR029C_p)|FD-Score:3.83|P-value:6.48E-5||SGD DESC:Putative protein of unknown function, deletion confers reduced fitness in saline Gene:YOL160W(YOL160W_d)|FD-Score:3.34|P-value:4.14E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YPR146C(YPR146C_d)|FD-Score:4.81|P-value:7.41E-7||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:ARF3(YOR094W)|FD-Score:3.5|P-value:2.29E-4||SGD DESC:Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity Gene:ASG1(YIL130W)|FD-Score:3.1|P-value:9.66E-4||SGD DESC:Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance Gene:ATG26(YLR189C)|FD-Score:3.13|P-value:8.66E-4||SGD DESC:UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy Gene:ATP5(YDR298C)|FD-Score:-3.21|P-value:6.55E-4||SGD DESC:Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated Gene:BAP2(YBR068C)|FD-Score:3.13|P-value:8.87E-4||SGD DESC:High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication Gene:BDF2(YDL070W)|FD-Score:5.56|P-value:1.33E-8||SGD DESC:Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress Gene:CAF20(YOR276W)|FD-Score:3.31|P-value:4.72E-4||SGD DESC:Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E Gene:CYB5(YNL111C)|FD-Score:3.1|P-value:9.69E-4||SGD DESC:Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation Gene:DGR2(YKL121W_p)|FD-Score:5.59|P-value:1.14E-8||SGD DESC:Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds Gene:DIA3(YDL024C)|FD-Score:4.1|P-value:2.08E-5||SGD DESC:Protein of unknown function, involved in invasive and pseudohyphal growth Gene:DPH2(YKL191W)|FD-Score:4.22|P-value:1.22E-5||SGD DESC:Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p Gene:ERV14(YGL054C)|FD-Score:3.87|P-value:5.48E-5||SGD DESC:COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication Gene:FMP16(YDR070C_p)|FD-Score:3.17|P-value:7.63E-4||SGD DESC:Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress Gene:GAS5(YOL030W)|FD-Score:5.6|P-value:1.06E-8||SGD DESC:1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall Gene:GET3(YDL100C)|FD-Score:3.93|P-value:4.32E-5||SGD DESC:Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress Gene:GMC1(YDR506C)|FD-Score:3.82|P-value:6.76E-5||SGD DESC:Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein Gene:HUT1(YPL244C)|FD-Score:3.88|P-value:5.19E-5||SGD DESC:Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1 Gene:INO1(YJL153C)|FD-Score:3.74|P-value:9.12E-5||SGD DESC:Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element Gene:KTR1(YOR099W)|FD-Score:4.12|P-value:1.90E-5||SGD DESC:Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress Gene:KTR3(YBR205W)|FD-Score:4.37|P-value:6.27E-6||SGD DESC:Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress Gene:LRE1(YCL051W)|FD-Score:3.21|P-value:6.75E-4||SGD DESC:Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway; <br>LRE1 has a paralog, HLR1, that arose from the whole genome duplication Gene:LRO1(YNR008W)|FD-Score:3.1|P-value:9.78E-4||SGD DESC:Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase Gene:MSB1(YOR188W)|FD-Score:-3.12|P-value:8.93E-4||SGD DESC:Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:NDI1(YML120C)|FD-Score:3.94|P-value:3.99E-5||SGD DESC:NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; upon apoptotic stress, Ndip is activated in the mitochondria by N-terminal cleavage, and the truncated protein translocates to the cytoplasm to induce apoptosis; homolog of human AMID Gene:NIS1(YNL078W)|FD-Score:3.75|P-value:8.84E-5||SGD DESC:Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network Gene:NPC2(YDL046W)|FD-Score:3.14|P-value:8.40E-4||SGD DESC:Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes Gene:OMS1(YDR316W)|FD-Score:3.34|P-value:4.13E-4||SGD DESC:Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations Gene:PEP7(YDR323C)|FD-Score:3.82|P-value:6.65E-5||SGD DESC:Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance Gene:PEX27(YOR193W)|FD-Score:4.93|P-value:4.19E-7||SGD DESC:Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p Gene:PEX32(YBR168W)|FD-Score:3.69|P-value:1.13E-4||SGD DESC:Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p Gene:RCF1(YML030W)|FD-Score:-3.25|P-value:5.69E-4||SGD DESC:Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast Gene:RPL20A(YMR242C)|FD-Score:4.17|P-value:1.52E-5||SGD DESC:Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication Gene:SAS2(YMR127C)|FD-Score:3.29|P-value:5.06E-4||SGD DESC:Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family Gene:SEF1(YBL066C)|FD-Score:3.15|P-value:8.08E-4||SGD DESC:Putative transcription factor, has homolog in Kluyveromyces lactis Gene:SHG1(YBR258C)|FD-Score:3.61|P-value:1.55E-4||SGD DESC:Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres Gene:SHM1(YBR263W)|FD-Score:5.66|P-value:7.48E-9||SGD DESC:Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine Gene:SNF6(YHL025W)|FD-Score:-10|P-value:4.86E-24||SGD DESC:Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions Gene:SOM1(YEL059C-A)|FD-Score:3.48|P-value:2.52E-4||SGD DESC:Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs Gene:SPR1(YOR190W)|FD-Score:3.22|P-value:6.39E-4||SGD DESC:Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance Gene:SWC3(YAL011W)|FD-Score:6.26|P-value:1.89E-10||SGD DESC:Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae Gene:TAH1(YCR060W)|FD-Score:4.1|P-value:2.09E-5||SGD DESC:Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II Gene:TIP1(YBR067C)|FD-Score:3.13|P-value:8.60E-4||SGD DESC:Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins Gene:UNG1(YML021C)|FD-Score:6.15|P-value:3.96E-10||SGD DESC:Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus Gene:VPS1(YKR001C)|FD-Score:-3.25|P-value:5.85E-4||SGD DESC:Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis Gene:YBR085C-A(YBR085C-A_p)|FD-Score:3.98|P-value:3.48E-5||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress Gene:YBR287W(YBR287W_p)|FD-Score:3.41|P-value:3.31E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene Gene:YDL050C(YDL050C_d)|FD-Score:3.97|P-value:3.55E-5||SGD DESC:Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR199W(YDR199W_d)|FD-Score:-3.11|P-value:9.28E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity Gene:YNR029C(YNR029C_p)|FD-Score:3.83|P-value:6.48E-5||SGD DESC:Putative protein of unknown function, deletion confers reduced fitness in saline Gene:YOL160W(YOL160W_d)|FD-Score:3.34|P-value:4.14E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YPR146C(YPR146C_d)|FD-Score:4.81|P-value:7.41E-7||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YMR290W-A_d5.601.09E-80.72YMR290W-A_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YGR147C4.895.11E-70.72NAT2Protein with an apparent role in acetylation of N-terminal methionine residues
YFR052W4.701.31E-60.72RPN12Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress
YKL165C4.513.26E-60.72MCD4Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
YNL222W3.797.55E-50.00SSU72Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo
YLR197W3.797.65E-50.24NOP56Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
YPL252C3.541.98E-40.01YAH1Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
YDR041W3.532.07E-40.14RSM10Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YIL129C3.393.52E-40.07TAO3Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
YPL146C3.324.46E-40.07NOP53Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired
YJR064W3.265.64E-40.08CCT5Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YOR207C3.187.40E-40.08RET1Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
YDR054C3.109.66E-40.16CDC34Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress
YDL143W2.940.001620.06CCT4Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YKL145W2.880.001980.06RPT1One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YAL011W6.261.89E-10SWC3Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
YML021C6.153.96E-10UNG1Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
YBR263W5.667.48E-9SHM1Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine
YOL030W5.601.06E-8GAS51,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
YKL121W_p5.591.14E-8DGR2_pProtein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds
YDL070W5.561.33E-8BDF2Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress
YOR193W4.934.19E-7PEX27Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p
YPR146C_d4.817.41E-7YPR146C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR205W4.376.27E-6KTR3Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress
YKL191W4.221.22E-5DPH2Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p
YMR242C4.171.52E-5RPL20ARibosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication
YOR099W4.121.90E-5KTR1Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress
YDL024C4.102.08E-5DIA3Protein of unknown function, involved in invasive and pseudohyphal growth
YCR060W4.102.09E-5TAH1Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II
YBR085C-A_p3.983.48E-5YBR085C-A_pProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress

GO enrichment analysis for SGTC_1200
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1284.19E-23SGTC_12092323-2347 50.3 μMChemDiv (Drug-like library)54127600.174419
0.1217.82E-21SGTC_11921488-0095 21.4 μMChemDiv (Drug-like library)9158750.0853659
0.1102.32E-17SGTC_11861319-0216 26.0 μMChemDiv (Drug-like library)45651360.0816327
0.1031.97E-15SGTC_12660828-0227 32.9 μMChemDiv (Drug-like library)39138200.0641026
0.1032.83E-15SGTC_13581509-0022 2.5 μMChemDiv (Drug-like library)32584340.148649
0.0899.40E-12SGTC_30909117696 49.5 μMChembridge (Drug-like library)79238210.142857
0.0864.76E-11SGTC_12550566-0045 221.0 μMChemDiv (Drug-like library)27884690.225352excess fatty acid
0.0814.37E-10SGTC_12153852-0577 11.2 μMChemDiv (Drug-like library)28848760.0769231
0.0808.05E-10SGTC_12011889-3372 45.9 μMChemDiv (Drug-like library)53921990.460317Golgi
0.0781.98E-9SGTC_11851319-0113 81.3 μMChemDiv (Drug-like library)46727630.1DNA damage response
0.0741.52E-8SGTC_13611608-0041 5.6 μMChemDiv (Drug-like library)X13610.146667RPP1 & pyrimidine depletion
0.0707.73E-8SGTC_12740865-0114 173.0 μMChemDiv (Drug-like library)8706240.0540541
0.0672.98E-7SGTC_12560570-0116 285.0 μMChemDiv (Drug-like library)4106380.0945946
0.0673.19E-7SGTC_9103454-3003 490.0 μMChemDiv (Drug-like library)8208240.0625
0.0664.03E-7SGTC_11323456-3614 2.5 μMChemDiv (Drug-like library)31255020.0879121tubulin folding & SWR complex

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_12072099-0101141 μM0.6666675837381ChemDiv (Drug-like library)378.177483.16115
SGTC_12011889-337245.9 μM0.4603175392199ChemDiv (Drug-like library)282.337023.49113Golgi
SGTC_9252064-127259.6 μM0.420296815817ChemDiv (Drug-like library)333.726481.44825
SGTC_1700st0308407.93 μM0.3974365499307TimTec (Natural product derivative library)359.333382.92417PDR1
SGTC_587k089-000357 μM0.3707879659696ChemDiv (Drug-like library)447.446642.62817
SGTC_615k087-0205167 μM0.3707879642773ChemDiv (Drug-like library)539.964245.8418
SGTC_7051124-0212310 μM0.3593759554485ChemDiv (Drug-like library)293.1484.01212
SGTC_9621254-030021.5 μM0.3561647340576ChemDiv (Drug-like library)406.058743.79114
SGTC_3214534-389065.3 μM0.351351699746ChemDiv (Drug-like library)345.82333.24704RPP1 & pyrimidine depletion
SGTC_1828st05581149 μM0.3513515877589TimTec (Natural product derivative library)407.803265.69205