1889-3372

N-[(Z)-benzylideneamino]-2-(3,4-dimethylphenoxy)acetamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1201
Screen concentration 45.9 μM
Source ChemDiv (Drug-like library)
PubChem CID 5392199
SMILES CC1=C(C=C(C=C1)OCC(=O)NN=CC2=CC=CC=C2)C
Standardized SMILES Cc1ccc(OCC(=O)NN=Cc2ccccc2)cc1C
Molecular weight 282.337
ALogP 3.49
H-bond donor count 1
H-bond acceptor count 3
Response signature Golgi

Pool Growth Kinetics
% growth inhibition (Het. pool) 33.67
% growth inhibition (Hom. pool) 5.5


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 5392199
Download HIP data (tab-delimited text)  (excel)
Gene:CMD1(YBR109C)|FD-Score:3.34|P-value:4.26E-4|Clearance:0.16||SGD DESC:Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin Gene:FAS1(YKL182W)|FD-Score:-3.61|P-value:1.51E-4|Clearance:0||SGD DESC:Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities Gene:FCF2(YLR051C)|FD-Score:3.73|P-value:9.56E-5|Clearance:0.25||SGD DESC:Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon Gene:NHP2(YDL208W)|FD-Score:-4.34|P-value:7.29E-6|Clearance:0||SGD DESC:Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing Gene:PCF11(YDR228C)|FD-Score:5.65|P-value:7.97E-9|Clearance:0.3||SGD DESC:mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping Gene:RAT1(YOR048C)|FD-Score:3.48|P-value:2.50E-4|Clearance:0.15||SGD DESC:Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination Gene:RPC40(YPR110C)|FD-Score:-3.7|P-value:1.09E-4|Clearance:0||SGD DESC:RNA polymerase subunit AC40, common to RNA polymerase I and III Gene:RPS3(YNL178W)|FD-Score:4.39|P-value:5.73E-6|Clearance:0.39||SGD DESC:Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3 Gene:RRB1(YMR131C)|FD-Score:6.67|P-value:1.27E-11|Clearance:1.02||SGD DESC:Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p Gene:SDS22(YKL193C)|FD-Score:4|P-value:3.18E-5|Clearance:0.13||SGD DESC:Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function Gene:SGV1(YPR161C)|FD-Score:-3.37|P-value:3.72E-4|Clearance:0||SGD DESC:Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p; similar to metazoan CDK9 proteins Gene:TAF10(YDR167W)|FD-Score:4.98|P-value:3.24E-7|Clearance:0.46||SGD DESC:Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification Gene:YBR124W(YBR124W_d)|FD-Score:-3.41|P-value:3.24E-4|Clearance:0||SGD DESC:Putative protein of unknown function Gene:YGR114C(YGR114C_d)|FD-Score:4.51|P-value:3.18E-6|Clearance:0.13||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6 Gene:YJL086C(YJL086C_d)|FD-Score:3.87|P-value:5.38E-5|Clearance:0.14||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1 Gene:YMR290W-A(YMR290W-A_d)|FD-Score:5.36|P-value:4.26E-8|Clearance:0.38||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase Gene:YPL238C(YPL238C_d)|FD-Score:3.17|P-value:7.59E-4|Clearance:0.09||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W Gene:CMD1(YBR109C)|FD-Score:3.34|P-value:4.26E-4|Clearance:0.16||SGD DESC:Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin Gene:FAS1(YKL182W)|FD-Score:-3.61|P-value:1.51E-4|Clearance:0||SGD DESC:Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities Gene:FCF2(YLR051C)|FD-Score:3.73|P-value:9.56E-5|Clearance:0.25||SGD DESC:Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon Gene:NHP2(YDL208W)|FD-Score:-4.34|P-value:7.29E-6|Clearance:0||SGD DESC:Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing Gene:PCF11(YDR228C)|FD-Score:5.65|P-value:7.97E-9|Clearance:0.3||SGD DESC:mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping Gene:RAT1(YOR048C)|FD-Score:3.48|P-value:2.50E-4|Clearance:0.15||SGD DESC:Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination Gene:RPC40(YPR110C)|FD-Score:-3.7|P-value:1.09E-4|Clearance:0||SGD DESC:RNA polymerase subunit AC40, common to RNA polymerase I and III Gene:RPS3(YNL178W)|FD-Score:4.39|P-value:5.73E-6|Clearance:0.39||SGD DESC:Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3 Gene:RRB1(YMR131C)|FD-Score:6.67|P-value:1.27E-11|Clearance:1.02||SGD DESC:Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p Gene:SDS22(YKL193C)|FD-Score:4|P-value:3.18E-5|Clearance:0.13||SGD DESC:Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function Gene:SGV1(YPR161C)|FD-Score:-3.37|P-value:3.72E-4|Clearance:0||SGD DESC:Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p; similar to metazoan CDK9 proteins Gene:TAF10(YDR167W)|FD-Score:4.98|P-value:3.24E-7|Clearance:0.46||SGD DESC:Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification Gene:YBR124W(YBR124W_d)|FD-Score:-3.41|P-value:3.24E-4|Clearance:0||SGD DESC:Putative protein of unknown function Gene:YGR114C(YGR114C_d)|FD-Score:4.51|P-value:3.18E-6|Clearance:0.13||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6 Gene:YJL086C(YJL086C_d)|FD-Score:3.87|P-value:5.38E-5|Clearance:0.14||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1 Gene:YMR290W-A(YMR290W-A_d)|FD-Score:5.36|P-value:4.26E-8|Clearance:0.38||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase Gene:YPL238C(YPL238C_d)|FD-Score:3.17|P-value:7.59E-4|Clearance:0.09||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 5392199
Download HOP data (tab-delimited text)  (excel)
Gene:ADE5,7(YGL234W)|FD-Score:3.35|P-value:4.11E-4||SGD DESC:Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities Gene:ALF1(YNL148C)|FD-Score:3.15|P-value:8.10E-4||SGD DESC:Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance Gene:AMS1(YGL156W)|FD-Score:-3.29|P-value:5.02E-4||SGD DESC:Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway Gene:APE4(YHR113W)|FD-Score:3.7|P-value:1.06E-4||SGD DESC:Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole; CVT pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family Gene:AQY2(YLL052C)|FD-Score:-4.06|P-value:2.45E-5||SGD DESC:Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains Gene:ARA2(YMR041C)|FD-Score:-3.88|P-value:5.32E-5||SGD DESC:NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase Gene:ARP5(YNL059C)|FD-Score:3.24|P-value:6.05E-4||SGD DESC:Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes Gene:AUS1(YOR011W)|FD-Score:3.82|P-value:6.60E-5||SGD DESC:Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen Gene:CIT2(YCR005C)|FD-Score:-4.25|P-value:1.08E-5||SGD DESC:Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors; CIT2 has a paralog, CIT1, that arose from the whole genome duplication Gene:COG6(YNL041C)|FD-Score:4.08|P-value:2.28E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG8(YML071C)|FD-Score:5.89|P-value:1.92E-9||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:DSE2(YHR143W)|FD-Score:3.09|P-value:9.93E-4||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP Gene:FLC3(YGL139W)|FD-Score:-3.61|P-value:1.52E-4||SGD DESC:Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER Gene:HLR1(YDR528W)|FD-Score:-3.25|P-value:5.72E-4||SGD DESC:Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A; <br>HLR1 has a paralog, LRE1, that arose from the whole genome duplication Gene:HMT1(YBR034C)|FD-Score:-3.1|P-value:9.63E-4||SGD DESC:Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region. Gene:IRC19(YLL033W)|FD-Score:3.57|P-value:1.76E-4||SGD DESC:Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci Gene:MTC1(YJL123C)|FD-Score:3.35|P-value:4.08E-4||SGD DESC:Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1 Gene:NAM7(YMR080C)|FD-Score:-3.94|P-value:4.01E-5||SGD DESC:ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress Gene:NIT1(YIL164C)|FD-Score:3.73|P-value:9.50E-5||SGD DESC:Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene Gene:NTE1(YML059C)|FD-Score:3.2|P-value:6.90E-4||SGD DESC:Serine esterase, homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes Gene:PFK27(YOL136C)|FD-Score:-3.34|P-value:4.24E-4||SGD DESC:6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A Gene:PGD1(YGL025C)|FD-Score:-3.83|P-value:6.49E-5||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor Gene:PKR1(YMR123W)|FD-Score:4.41|P-value:5.21E-6||SGD DESC:V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress Gene:RAV1(YJR033C)|FD-Score:3.78|P-value:7.90E-5||SGD DESC:Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate Gene:RPL22B(YFL034C-A)|FD-Score:-3.55|P-value:1.89E-4||SGD DESC:Ribosomal 60S subunit protein L22B; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication Gene:SAS5(YOR213C)|FD-Score:-7.01|P-value:1.23E-12||SGD DESC:Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity Gene:SDL1(YIL167W)|FD-Score:-3.44|P-value:2.88E-4||SGD DESC:Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other <i>S. cerevisiae</i> strain backgrounds YIL167W and adjacent ORF, YIL168W, constitute a single ORF encoding L-serine dehydratase Gene:SHM1(YBR263W)|FD-Score:4.93|P-value:4.09E-7||SGD DESC:Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine Gene:SLA1(YBL007C)|FD-Score:5.53|P-value:1.58E-8||SGD DESC:Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains Gene:STF2(YGR008C)|FD-Score:-4.14|P-value:1.70E-5||SGD DESC:Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress Gene:SWC3(YAL011W)|FD-Score:4.6|P-value:2.12E-6||SGD DESC:Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae Gene:TDH1(YJL052W)|FD-Score:-3.33|P-value:4.37E-4||SGD DESC:Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress Gene:TPO3(YPR156C)|FD-Score:3.09|P-value:9.94E-4||SGD DESC:Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication Gene:URA4(YLR420W)|FD-Score:-4.19|P-value:1.40E-5||SGD DESC:Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate Gene:VPS1(YKR001C)|FD-Score:3.37|P-value:3.73E-4||SGD DESC:Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis Gene:VPS63(YLR261C_d)|FD-Score:3.14|P-value:8.56E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect Gene:YBL010C(YBL010C_p)|FD-Score:-3.3|P-value:4.83E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles Gene:YBR134W(YBR134W_d)|FD-Score:3.23|P-value:6.27E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YDL057W(YDL057W_p)|FD-Score:-4.27|P-value:9.87E-6||SGD DESC:Putative protein of unknown function; YDL057W is not an essential gene Gene:YDR541C(YDR541C_p)|FD-Score:-3.53|P-value:2.06E-4||SGD DESC:Putative dihydrokaempferol 4-reductase Gene:YFL051C(YFL051C_p)|FD-Score:4.11|P-value:2.00E-5||SGD DESC:Putative protein of unknown function; YFL051C is not an essential gene Gene:YFR020W(YFR020W_p)|FD-Score:-3.39|P-value:3.44E-4||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YGL159W(YGL159W_p)|FD-Score:-4.08|P-value:2.24E-5||SGD DESC:Putative protein of unknown function; deletion mutant has no detectable phenotype Gene:YHR097C(YHR097C_p)|FD-Score:3.81|P-value:6.81E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus Gene:YKL096C-B(YKL096C-B_p)|FD-Score:3.22|P-value:6.36E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YKL169C(YKL169C_d)|FD-Score:4.72|P-value:1.21E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38 Gene:YKL202W(YKL202W_d)|FD-Score:-3.59|P-value:1.67E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR169W(YLR169W_d)|FD-Score:-3.31|P-value:4.70E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR194C(YLR194C)|FD-Score:4.23|P-value:1.18E-5||SGD DESC:Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress Gene:YMR010W(YMR010W_p)|FD-Score:3.12|P-value:8.93E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1 Gene:YNL193W(YNL193W_p)|FD-Score:3.36|P-value:3.97E-4||SGD DESC:Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis Gene:YNR066C(YNR066C_p)|FD-Score:3.9|P-value:4.86E-5||SGD DESC:Putative membrane-localized protein of unknown function Gene:YPL162C(YPL162C_p)|FD-Score:3.3|P-value:4.84E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology Gene:ADE5,7(YGL234W)|FD-Score:3.35|P-value:4.11E-4||SGD DESC:Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities Gene:ALF1(YNL148C)|FD-Score:3.15|P-value:8.10E-4||SGD DESC:Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance Gene:AMS1(YGL156W)|FD-Score:-3.29|P-value:5.02E-4||SGD DESC:Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway Gene:APE4(YHR113W)|FD-Score:3.7|P-value:1.06E-4||SGD DESC:Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole; CVT pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family Gene:AQY2(YLL052C)|FD-Score:-4.06|P-value:2.45E-5||SGD DESC:Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains Gene:ARA2(YMR041C)|FD-Score:-3.88|P-value:5.32E-5||SGD DESC:NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase Gene:ARP5(YNL059C)|FD-Score:3.24|P-value:6.05E-4||SGD DESC:Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes Gene:AUS1(YOR011W)|FD-Score:3.82|P-value:6.60E-5||SGD DESC:Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen Gene:CIT2(YCR005C)|FD-Score:-4.25|P-value:1.08E-5||SGD DESC:Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors; CIT2 has a paralog, CIT1, that arose from the whole genome duplication Gene:COG6(YNL041C)|FD-Score:4.08|P-value:2.28E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG8(YML071C)|FD-Score:5.89|P-value:1.92E-9||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:DSE2(YHR143W)|FD-Score:3.09|P-value:9.93E-4||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP Gene:FLC3(YGL139W)|FD-Score:-3.61|P-value:1.52E-4||SGD DESC:Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER Gene:HLR1(YDR528W)|FD-Score:-3.25|P-value:5.72E-4||SGD DESC:Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A; <br>HLR1 has a paralog, LRE1, that arose from the whole genome duplication Gene:HMT1(YBR034C)|FD-Score:-3.1|P-value:9.63E-4||SGD DESC:Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region. Gene:IRC19(YLL033W)|FD-Score:3.57|P-value:1.76E-4||SGD DESC:Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci Gene:MTC1(YJL123C)|FD-Score:3.35|P-value:4.08E-4||SGD DESC:Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1 Gene:NAM7(YMR080C)|FD-Score:-3.94|P-value:4.01E-5||SGD DESC:ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress Gene:NIT1(YIL164C)|FD-Score:3.73|P-value:9.50E-5||SGD DESC:Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene Gene:NTE1(YML059C)|FD-Score:3.2|P-value:6.90E-4||SGD DESC:Serine esterase, homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes Gene:PFK27(YOL136C)|FD-Score:-3.34|P-value:4.24E-4||SGD DESC:6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A Gene:PGD1(YGL025C)|FD-Score:-3.83|P-value:6.49E-5||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor Gene:PKR1(YMR123W)|FD-Score:4.41|P-value:5.21E-6||SGD DESC:V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress Gene:RAV1(YJR033C)|FD-Score:3.78|P-value:7.90E-5||SGD DESC:Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate Gene:RPL22B(YFL034C-A)|FD-Score:-3.55|P-value:1.89E-4||SGD DESC:Ribosomal 60S subunit protein L22B; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication Gene:SAS5(YOR213C)|FD-Score:-7.01|P-value:1.23E-12||SGD DESC:Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity Gene:SDL1(YIL167W)|FD-Score:-3.44|P-value:2.88E-4||SGD DESC:Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other <i>S. cerevisiae</i> strain backgrounds YIL167W and adjacent ORF, YIL168W, constitute a single ORF encoding L-serine dehydratase Gene:SHM1(YBR263W)|FD-Score:4.93|P-value:4.09E-7||SGD DESC:Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine Gene:SLA1(YBL007C)|FD-Score:5.53|P-value:1.58E-8||SGD DESC:Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains Gene:STF2(YGR008C)|FD-Score:-4.14|P-value:1.70E-5||SGD DESC:Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress Gene:SWC3(YAL011W)|FD-Score:4.6|P-value:2.12E-6||SGD DESC:Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae Gene:TDH1(YJL052W)|FD-Score:-3.33|P-value:4.37E-4||SGD DESC:Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress Gene:TPO3(YPR156C)|FD-Score:3.09|P-value:9.94E-4||SGD DESC:Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication Gene:URA4(YLR420W)|FD-Score:-4.19|P-value:1.40E-5||SGD DESC:Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate Gene:VPS1(YKR001C)|FD-Score:3.37|P-value:3.73E-4||SGD DESC:Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis Gene:VPS63(YLR261C_d)|FD-Score:3.14|P-value:8.56E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect Gene:YBL010C(YBL010C_p)|FD-Score:-3.3|P-value:4.83E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles Gene:YBR134W(YBR134W_d)|FD-Score:3.23|P-value:6.27E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YDL057W(YDL057W_p)|FD-Score:-4.27|P-value:9.87E-6||SGD DESC:Putative protein of unknown function; YDL057W is not an essential gene Gene:YDR541C(YDR541C_p)|FD-Score:-3.53|P-value:2.06E-4||SGD DESC:Putative dihydrokaempferol 4-reductase Gene:YFL051C(YFL051C_p)|FD-Score:4.11|P-value:2.00E-5||SGD DESC:Putative protein of unknown function; YFL051C is not an essential gene Gene:YFR020W(YFR020W_p)|FD-Score:-3.39|P-value:3.44E-4||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YGL159W(YGL159W_p)|FD-Score:-4.08|P-value:2.24E-5||SGD DESC:Putative protein of unknown function; deletion mutant has no detectable phenotype Gene:YHR097C(YHR097C_p)|FD-Score:3.81|P-value:6.81E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus Gene:YKL096C-B(YKL096C-B_p)|FD-Score:3.22|P-value:6.36E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YKL169C(YKL169C_d)|FD-Score:4.72|P-value:1.21E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38 Gene:YKL202W(YKL202W_d)|FD-Score:-3.59|P-value:1.67E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR169W(YLR169W_d)|FD-Score:-3.31|P-value:4.70E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR194C(YLR194C)|FD-Score:4.23|P-value:1.18E-5||SGD DESC:Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress Gene:YMR010W(YMR010W_p)|FD-Score:3.12|P-value:8.93E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1 Gene:YNL193W(YNL193W_p)|FD-Score:3.36|P-value:3.97E-4||SGD DESC:Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis Gene:YNR066C(YNR066C_p)|FD-Score:3.9|P-value:4.86E-5||SGD DESC:Putative membrane-localized protein of unknown function Gene:YPL162C(YPL162C_p)|FD-Score:3.3|P-value:4.84E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YMR131C6.671.27E-111.02RRB1Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p
YDR228C5.657.97E-90.29PCF11mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping
YMR290W-A_d5.364.26E-80.38YMR290W-A_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YDR167W4.983.24E-70.46TAF10Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
YGR114C_d4.513.18E-60.13YGR114C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6
YNL178W4.395.73E-60.39RPS3Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
YKL193C4.003.18E-50.13SDS22Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function
YJL086C_d3.875.38E-50.14YJL086C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1
YLR051C3.739.56E-50.25FCF2Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon
YOR048C3.482.50E-40.15RAT1Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination
YBR109C3.344.26E-40.16CMD1Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin
YPL238C_d3.177.59E-40.09YPL238C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W
YHR072W3.080.001020.06ERG7Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
YIL115C3.020.001250.03NUP159FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)
YKL059C2.990.001370.03MPE1Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YML071C5.891.92E-9COG8Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YBL007C5.531.58E-8SLA1Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains
YBR263W4.934.09E-7SHM1Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine
YKL169C_d4.721.21E-6YKL169C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38
YAL011W4.602.12E-6SWC3Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
YMR123W4.415.21E-6PKR1V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress
YLR194C4.231.18E-5YLR194CStructural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress
YFL051C_p4.112.00E-5YFL051C_pPutative protein of unknown function; YFL051C is not an essential gene
YNL041C4.082.28E-5COG6Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YNR066C_p3.904.86E-5YNR066C_pPutative membrane-localized protein of unknown function
YOR011W3.826.60E-5AUS1Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen
YHR097C_p3.816.81E-5YHR097C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YJR033C3.787.90E-5RAV1Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
YIL164C3.739.50E-5NIT1Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene
YHR113W3.701.06E-4APE4Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole; CVT pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family

GO enrichment analysis for SGTC_1201
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1071.45E-16SGTC_13631636-0063 10.4 μMChemDiv (Drug-like library)60721850.241935Golgi
0.0903.44E-12SGTC_1078idebenone 36.1 μMMiscellaneous36860.0952381Golgi
0.0863.11E-11SGTC_1669st015249 58.4 μMTimTec (Natural product derivative library)7227930.19403Golgi
0.0831.70E-10SGTC_2727riluzole 51.8 μMMiscellaneous50700.109375mitochondrial processes
0.0808.05E-10SGTC_12001643-0193 18.4 μMChemDiv (Drug-like library)54039740.460317
0.0791.18E-9SGTC_3660181-0206 4.3 μMChemDiv (Drug-like library)2748740.0740741Golgi
0.0781.61E-9SGTC_6320781-2353 4.7 μMChemDiv (Drug-like library)68115150.113924Golgi
0.0781.72E-9SGTC_14153966-0071 78.1 μMChemDiv (Drug-like library)28931850.178571DNA intercalators
0.0781.75E-9SGTC_10603448-7350 82.0 μMChemDiv (Drug-like library)5701780.166667Golgi
0.0772.71E-9SGTC_29025787006 60.5 μMChembridge (Drug-like library)5910030.126761Golgi
0.0773.51E-9SGTC_30579095946 49.5 μMChembridge (Drug-like library)245400430.108108Golgi
0.0765.75E-9SGTC_32699137823 49.5 μMChembridge (Drug-like library)176829360.14864960S ribosome export
0.0741.56E-8SGTC_31669102297 49.5 μMChembridge (Drug-like library)252370720.142857Golgi
0.0723.09E-8SGTC_2737bleomycin 30.5 nMMiscellaneous162113180.0578035Golgi
0.0723.14E-8SGTC_624k048-0052 28.0 μMChemDiv (Drug-like library)68355310.188406Golgi

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_12001643-019318.4 μM0.4603175403974ChemDiv (Drug-like library)347.753063.56315
SGTC_12072099-0101141 μM0.4426235837381ChemDiv (Drug-like library)378.177483.16115
SGTC_1607st00030550.6 μM0.4354845457690TimTec (Natural product derivative library)395.27423.37216
SGTC_2981901395238.96 μM0.4035092996344Chembridge (Drug-like library)348.234324.39112
SGTC_7051124-0212310 μM0.3888899554485ChemDiv (Drug-like library)293.1484.01212
SGTC_2988907364071.43 μM0.3818189102229Chembridge (Drug-like library)283.364843.91512
SGTC_21075363541170.16 μM0.372549244052Chembridge (Fragment library)199.63421.81812
SGTC_11841269-1718139 μM0.3684215403821ChemDiv (Drug-like library)260.311582.6214
SGTC_7911348-1292225 μM0.3676475437054ChemDiv (Drug-like library)465.294543.2917
SGTC_9781416-051287.4 μM0.3559326814003ChemDiv (Drug-like library)270.283260.69424redox potentiating