Deletion Strain | FD score | P-value | Gene | Gene Description |
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YMR196W_p | 7.73 | 5.54E-15 | YMR196W_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene |
YLR455W_p | 7.62 | 1.25E-14 | YLR455W_p | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); protein abundance increases in response to DNA replication stress |
YER046W | 7.47 | 4.06E-14 | SPO73 | Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis |
YGR206W | 7.41 | 6.12E-14 | MVB12 | ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin |
YML026C | 6.94 | 2.01E-12 | RPS18B | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress |
YMR182C | 5.92 | 1.57E-9 | RGM1 | Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication |
YER051W | 5.56 | 1.35E-8 | JHD1 | JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe |
YGL153W | 5.43 | 2.89E-8 | PEX14 | Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p |
YMR320W_d | 5.37 | 3.97E-8 | YMR320W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YLR425W | 5.23 | 8.28E-8 | TUS1 | Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate |
YHR171W | 5.11 | 1.64E-7 | ATG7 | Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation |
YDR419W | 4.94 | 4.00E-7 | RAD30 | DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV |
YJR025C | 4.69 | 1.40E-6 | BNA1 | 3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p |
YBR296C-A_p | 4.63 | 1.82E-6 | YBR296C-A_p | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
YDR462W | 4.53 | 2.99E-6 | MRPL28 | Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress |