| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YOR213C | 13.70 | 5.78E-43 | SAS5 | Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity |
| YNL090W | 12.40 | 1.37E-35 | RHO2 | Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly |
| YPR134W | 9.15 | 2.85E-20 | MSS18 | Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions |
| YPL270W | 8.43 | 1.72E-17 | MDL2 | Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis |
| YDR354W | 6.35 | 1.08E-10 | TRP4 | Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis |
| YCR026C | 6.32 | 1.33E-10 | NPP1 | Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP1 has a paralog, NPP2, that arose from the whole genome duplication |
| YCR060W | 6.29 | 1.54E-10 | TAH1 | Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II |
| YGL056C | 5.54 | 1.51E-8 | SDS23 | One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication |
| YPL164C | 5.51 | 1.78E-8 | MLH3 | Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability |
| YOR228C | 5.24 | 8.22E-8 | YOR228C | Protein of unknown function, localized to the mitochondrial outer membrane |
| YJL080C | 5.12 | 1.56E-7 | SCP160 | Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins |
| YEL059W_d | 4.95 | 3.80E-7 | HHY1_d | Dubious open reading frame unlikely to encode a functional protein; mutant is hypersensitive to hygromycin B indicative of defects in vacuolar trafficking |
| YDL052C | 4.95 | 3.81E-7 | SLC1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes |
| YDR233C | 4.78 | 8.65E-7 | RTN1 | Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; mutant overexpressing RTN1 shows increase in tubular ER; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; more abundant than Rtn2p; member of the RTNLA subfamily; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; RTN1 has a paralog, RTN2, that arose from the whole genome duplication |
| YPR109W_p | 4.67 | 1.47E-6 | YPR109W_p | Predicted membrane protein; dipoid deletion strain has high budding index |
