| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YLR047C | 5.87 | 2.16E-9 | FRE8 | Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p |
| YHR157W | 5.60 | 1.08E-8 | REC104 | Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination |
| YPL239W | 5.54 | 1.54E-8 | YAR1 | Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock |
| YER111C | 5.06 | 2.10E-7 | SWI4 | DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p |
| YOR350C | 4.93 | 4.15E-7 | MNE1 | Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA |
| YGR285C | 4.60 | 2.07E-6 | ZUO1 | Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p |
| YDR348C | 4.40 | 5.51E-6 | PAL1 | Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress |
| YAL005C | 4.38 | 6.04E-6 | SSA1 | ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils |
| YLR342W-A_p | 4.28 | 9.20E-6 | YLR342W-A_p | Putative protein of unknown function |
| YDL026W_d | 4.28 | 9.40E-6 | YDL026W_d | Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data |
| YAL027W | 4.25 | 1.07E-5 | SAW1 | 5'- and 3'-flap DNA binding protein; stimulates the endonuclease activity of Rad1/Rad10p; involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during double-strand break repair via single-strand annealing; green fluorescent protein (GFP)-fusion protein localizes to the nucleus |
| YAL020C | 4.23 | 1.17E-5 | ATS1 | Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle |
| YDR525W_d | 4.21 | 1.26E-5 | API2_d | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology |
| YGR282C | 4.16 | 1.57E-5 | BGL2 | Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance |
| YPL015C | 4.14 | 1.76E-5 | HST2 | Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export |
