Deletion Strain | FD score | P-value | Gene | Gene Description |
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YBR229C | 18.80 | 1.57E-79 | ROT2 | Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations |
YLR120C | 17.90 | 4.93E-72 | YPS1 | Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor |
YIL154C | 12.10 | 3.17E-34 | IMP2' | Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat |
YBL006C | 11.80 | 1.11E-32 | LDB7 | Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions |
YDL066W | 10.20 | 7.53E-25 | IDP1 | Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes |
YJL192C | 10.10 | 4.30E-24 | SOP4 | ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER |
YCR008W | 10.00 | 5.41E-24 | SAT4 | Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p |
YBL051C | 8.87 | 3.50E-19 | PIN4 | Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage |
YLR322W_d | 8.12 | 2.31E-16 | VPS65_d | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth |
YDR264C | 7.87 | 1.74E-15 | AKR1 | Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication |
YGR056W | 7.19 | 3.30E-13 | RSC1 | Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook |
YHR041C | 6.59 | 2.14E-11 | SRB2 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance |
YJL129C | 6.45 | 5.46E-11 | TRK1 | Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication |
YNR040W_p | 6.43 | 6.50E-11 | YNR040W_p | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
YBR296C-A_p | 6.37 | 9.29E-11 | YBR296C-A_p | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |