| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YGR089W | 4.39 | 5.59E-6 | NNF2 | Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation |
| YDL044C | 4.36 | 6.65E-6 | MTF2 | Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription |
| YPR017C | 4.20 | 1.35E-5 | DSS4 | Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol |
| YPL064C | 4.05 | 2.56E-5 | CWC27 | Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress |
| YIL168W | 4.01 | 2.97E-5 | YIL168W | Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other S. cerevisiae strain backgrounds YIL168W and adjacent ORF, YIL167W, constitute a single ORF encoding L-serine dehydratase |
| YDR451C | 4.01 | 3.00E-5 | YHP1 | Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication |
| YIR039C | 3.94 | 4.05E-5 | YPS6 | Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance |
| YBL022C | 3.89 | 4.97E-5 | PIM1 | ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria |
| YGR174W-A_p | 3.81 | 6.97E-5 | YGR174W-A_p | Putative protein of unknown function; predicted to have a role in cell budding based on computational guilt by association analysis |
| YKR007W | 3.80 | 7.33E-5 | MEH1 | Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification |
| YHR115C | 3.78 | 7.76E-5 | DMA1 | Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma2p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8 protein, similar to human Chfr; contains FHA and RING finger |
| YDL089W | 3.74 | 9.21E-5 | NUR1 | Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate |
| YJR154W_p | 3.73 | 9.75E-5 | YJR154W_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |
| YPR145W | 3.70 | 1.10E-4 | ASN1 | Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication |
| YLR096W | 3.68 | 1.16E-4 | KIN2 | Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p |
