Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
---|
YMR309C | 5.99 | 1.05E-9 | 1.16 | NIP1 | eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection |
YKL192C | 4.83 | 6.90E-7 | 0.34 | ACP1 | Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p |
YBL026W | 4.48 | 3.65E-6 | 0.31 | LSM2 | Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress |
YGL044C | 4.18 | 1.48E-5 | 0.19 | RNA15 | Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping |
YDL014W | 3.98 | 3.39E-5 | 0.18 | NOP1 | Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin |
YLR009W | 3.80 | 7.27E-5 | 0.08 | RLP24 | Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp |
YNL113W | 3.72 | 9.97E-5 | 0.03 | RPC19 | RNA polymerase subunit AC19, common to RNA polymerases I and III |
YML092C | 3.69 | 1.12E-4 | 0.01 | PRE8 | Alpha 2 subunit of the 20S proteasome |
YLR105C | 3.68 | 1.18E-4 | 0.06 | SEN2 | Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease |
YOL005C | 3.62 | 1.48E-4 | 0.21 | RPB11 | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit |
YKR025W | 3.41 | 3.28E-4 | 0.18 | RPC37 | RNA polymerase III subunit C37 |
YEL055C | 3.23 | 6.28E-4 | 0.11 | POL5 | DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA |
YBL040C | 3.11 | 9.29E-4 | 0.26 | ERD2 | HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins |
YFR050C | 2.85 | 0.00216 | 0.06 | PRE4 | Beta 7 subunit of the 20S proteasome |
YOR250C | 2.79 | 0.00260 | 0.00 | CLP1 | Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation |