Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YDR081C | 4.27 | 9.82E-6 | 0.40 | PDC2 | Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions |
YLR340W | 3.87 | 5.41E-5 | 0.39 | RPP0 | Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10 |
YEL055C | 3.48 | 2.49E-4 | 0.00 | POL5 | DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA |
YOR262W | 3.48 | 2.51E-4 | 0.33 | GPN2 | Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B; required for establishment of sister chromatid cohesion |
YDL205C | 3.15 | 8.06E-4 | 0.02 | HEM3 | Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme |
YDL212W | 3.13 | 8.75E-4 | 0.03 | SHR3 | Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface |
YLR310C | 3.10 | 9.54E-4 | 0.03 | CDC25 | Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1 |
YDL141W | 3.08 | 0.00105 | 0.00 | BPL1 | Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation |
YNL002C | 3.08 | 0.00105 | 0.00 | RLP7 | Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs |
YKL024C | 3.07 | 0.00106 | 0.03 | URA6 | Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP) |
YDL220C | 3.04 | 0.00120 | 0.08 | CDC13 | Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping; autophagy and proteasome are involved in Cdc13p degradation |
YBR049C | 2.96 | 0.00155 | 0.03 | REB1 | RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; REB1 has a paralog, NSI1, that arose from the whole genome duplication |
YMR028W | 2.93 | 0.00172 | 0.03 | TAP42 | Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits |
YKL006C-A | 2.90 | 0.00188 | 0.02 | SFT1 | Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment |
YIL106W | 2.88 | 0.00201 | 0.04 | MOB1 | Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress |